A multi-institutional team of researchers has sequenced the DNA of 6,700 exomes, the portion of the genome that contains protein-coding genes, as part of the National Heart, Lung and Blood Institute (NHLBI)-funded Exome Sequencing Project, one of the largest medical sequencing studies ever undertaken. Scientists participating in the project initially expected that individual rare variants would have a greater effect on over 80 heart, lung and blood related traits and diseases of high public health significance, said Suzanne M. Leal, Ph.D., professor and director, Center ...

SALT LAKE CITY – Cardiology researchers at the Intermountain Medical Center Heart Institute have found that approximately 75 percent of patients taking two common blood-thinning drugs may be receiving the wrong dosage levels, according to a new study. This could put them at risk for serious problems like uncontrolled bleeding or developing blood clots. Millions of Americans with coronary artery disease take one of the two drugs — clopidogrel (Plavix) and prasugrel (Effient) — to prevent harmful blood clots that can cause a stroke or heart attack. Current guidelines ...

Researchers from Aarhus University, Denmark, have now discovered an important mechanism behind one of our most fundamental lines of immune function. The discovery has been published in the esteemed scientific journal, The Journal of Immunology, where it has been highlighted as a top story. In collaboration with colleagues from USA and Turkey, they have discovered exactly which enzymes collaborate in the first line of the immune defence. Thus, they answer a central question about the so-called complement system, which has been a focal point of the scientific field for the ...

VIDEO: Figaro, a Goffin's Cockatoo, makes and uses a tool. Click here for more information. Goffin's cockatoos are a highly playful and curious Indonesian cockatoo species. Therefore, cognitive biologists are now using them as a model species to investigate intelligent behaviour in birds. Together with researchers from the University of Oxford, Alice Auersperg and Birgit Szabo from the Department of Cognitive Biology at the University of Vienna have made a sensational discovery: ...

With its deeply embedded roots, sturdy trunk and dense profusion of branches, the Tree of Life is a structure of nearly unfathomable complexity and beauty. While major strides have been made to establish the evolutionary hierarchy encompassing every living species, the project is still in its infancy. At Arizona State University's Biodesign Institute, Sudhir Kumar has been filling in the Tree of Life by developing sophisticated methods and bioinformatics tools. His latest research, which appeared on the advance online edition of the Proceedings of the National Academy ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with an occurrence rate in France similar to multiple sclerosis (two to three new cases per year for every 100,000 residents). It has a specific affect on neurons responsible for motor control, in particular motor neurones and central motor neurones. The former, located in the spinal cord, are directly linked to muscles and are used for muscle contraction and stretching. The latter, located in the brain, receive movement orders. As the disease develops, the neurons degenerate and the muscles are no longer ...

To this day it remains a mystery why the cerebral pressure in certain people suddenly increases. The consequences, however, are better understood: The blood circulation is disrupted and after a while parts of the brain may die off, similar to what occurs in a stroke. This is how dementia takes its insidious path. Experts estimate that up to ten percent of all cases of dementia in Europe can be attributed to rising blood pressure in the brain. Still, making the diagnosis is tough. People with a heightened susceptibility to a rise in intracranial pressure must be treated ...

Each year throughout the world, up to 22 million tons of rubber are processed and a large portion of it goes into the production of vehicle tires. Once the products reach the end of their useful life, they typically land in the incinerator. In the best case, the waste rubber is recycled into secondary products. Ground to powder, the rubber residues can be found, for example, in the floor coverings used at sports arenas and playgrounds, and in doormats. But until now, the appropriate techniques for producing high-quality materials from these recyclables did not exist. Researchers ...

Extended work shifts of twelve hours or longer are common and popular among hospital staff nurses, but a new study reports that nurses working longer shifts were more likely to experience burnout, job dissatisfaction, and patients were more dissatisfied with their care. In the first study to examine the relationship between nurse shift length and patients' assessment of care, researchers from the University of Pennsylvania School of Nursing report that nurses working shifts of ten hours or longer were up to two and a half times more likely than nurses working shorter ...

(Philadelphia, PA) – Scientists for the first time have evidence showing how a widely used type of "targeted" cancer drug can be dangerous to the heart. Studying mice with the equivalent of a heart attack, researchers found that the drug sorafenib (Nexavar) – which inhibits proteins called tyrosine kinase receptors (RTKs), and is used in kidney and liver cancer treatment – can interfere with heart stem cell activity, affecting the heart's ability to repair itself after injury. The findings suggest that sorafenib and other similar drugs that target these kinds of protein ...

(Philadelphia, PA) – When a person has a heart attack, portions of the heart muscle die in the next several days or even weeks if deprived of oxygen for long enough. The recovering heart slowly remodels itself, even fostering the growth of new blood vessels, in an attempt to regain some of its former function. But all too often, the remodeling is actually harmful, and the damaged heart is on an inevitable downward slide to heart failure. Now, scientists at the Center for Translational Medicine at Temple University School of Medicine have identified a key target they hope ...

DUBLIN, November 6, 2012 – Taiho Pharmaceutical Co., Ltd. (HQ: Tokyo, President: Masayuki Kobayashi), the developer of the first orally available fluorouracil (FU) Chemotherapeutic treatment (TS-1/S-1), is presenting early stage data for eight novel oncology compounds, including potential first-in-class therapies. The data being presented during the 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics from November 6 – 9, 2012 in Dublin, Ireland underscore Taiho's steadfast commitment to improving cornerstone anti-metabolic cancer agents and developing ...

Boston, Mass.—Using a combination of surgical procedures developed over the last 11 years, surgeons at Boston Children's Hospital have established a new approach for rebuilding the heart in children born with a severe heart defect called hypoplastic left heart syndrome (HLHS). This "staged left ventricle recruitment" (SLVR) strategy uses the existing standard single-ventricle treatment for HLHS and additional procedures to spur the body's capacity for healing and growth and encourage the small left ventricle in these children to grow and function. Members of Boston Children's ...

Bacteria can talk to each other via molecules they themselves produce. The phenomenon is called quorum sensing, and is important when an infection propagates. Now, researchers at Linköping University in Sweden are showing how bacteria control processes in human cells the same way. The results are being published in the journal PLOS Pathogens with Elena Vikström, researcher in Medical Microbiology, as the main author. When an infection is signaled, more and more bacteria gather at the site of the attack – a wound, for example. When there are enough of them, they start ...

New surveys of researchers and funders reveal a lack of consensus regarding researching and developing interventions to prevent prematurity and stillbirth, according to an article published in the American Journal of Obstetrics and Gynecology ahead of World Prematurity Day on November 17. Authored by Michael G. Gravett, MD, scientific director of the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS), an initiative of Seattle Children's, and Craig E. Rubens, MD, PhD, executive director of GAPPS, the article outlines significant opportunities to enhance research ...

This protection is provided by a human protein, Elafin, which is artificially introduced into dairy produce bacteria (Lactococcus lactis and Lactobacillus casei). In time, this discovery could be useful for individuals suffering from chronic inflammatory diseases such as Crohn's disease or ulcerative colitis. The results of this research were published in the Science Translational Medicine review on 31 October 2012. In France, nearly 200,000 individuals suffer from chronic inflammatory bowel disease, known as IBD, (specifically Crohn's disease and ulcerative colitis). ...

A world-famous mathematician responsible for solving one of the subject's most challenging problems has published his latest work as a University of Leicester research report. This follows the visit that famed mathematician Yuri Matiyasevich made to the Department of Mathematics where he talked about his pioneering work. He visited UK by invitation of the Isaac Newton Institute for Mathematical Sciences. In 1900, twenty-three unsolved mathematical problems, known as Hilbert's Problems, were compiled as a definitive list by mathematician David Hilbert. A century later, ...

Jerusalem, Nov. 6, 2012 -- Identifying fingerprints on paper is a commonly used method in police forensic work, but unfortunately it is not easy to make those fingerprints visible. Now, scientists at the Hebrew University of Jerusalem have developed a new approach for making such fingerprints more readily readable. The new method, created by a team headed by Prof. Yossi Almog and Prof. Daniel Mandler of the Institute of Chemistry at the Hebrew University, uses an innovative chemical process to produce a negative of the fingerprint image rather than the positive image ...

This press release is available in German. Methane is formed under the absence of oxygen by natural biological and physical processes, e.g. in the sea floor. It is a much more powerful greenhouse gas than carbon dioxide. Thanks to the activity of microorganisms this gas is inactivated before it reaches the atmosphere and unfolds its harmful effects on Earth's climate. Researchers from Bremen have now proven that these microorganisms are quite picky about their diet. All life on Earth is based on carbon and its compounds. Cell components of all creatures contain carbon. ...

When given early treatment, children with autism spectrum disorders (ASD) made significant improvements in behavior, communication, and most strikingly, brain function, Yale School of Medicine researchers report in a new study. The study was published in the current issue of the Journal of Autism and Developmental Disorders by Yale Child Study Center researchers Fred Volkmar, M.D., Kevin A. Pelphrey, and their colleagues. The results suggest that brain systems supporting social perception respond well to an early intervention behavioral program called pivotal response ...

MINNEAPOLIS, MN – November 6, 2012 – When a cardiologist attends to heart failure patients, even when the severity of illness is higher, patients have reduced rates of hospital readmissions, compared with those patients who are treated by a hospitalist, according to a trial being presented today at the American Heart Association's scientific sessions in Los Angeles. Congestive heart failure (CHF) is the most common cause for hospital readmission in patients over the age of 65 years. Whereas efforts to reduce readmission rates have focused on transitions of care and short-term ...

"Travel broadens the mind" goes the old adage, and potential employers often agree, valuing the open-mindedness and creativity fostered by such worldliness. But according to new Tel Aviv University research, not all international experiences are created equal. "Although living abroad does help to hone creative abilities, not all individuals who have lived abroad derive an equal benefit from such experiences," explains Dr. Carmit Tadmor of TAU's Recanati School of Business, who conducted the study with Dr. Adam Galinsky of the Kellogg School of Management at Northwestern ...

CHAMPAIGN, lll. — Scientists have identified a group of small molecules that interfere with the activity of a compound that initiates multiple steps in blood clotting, including those that lead to the obstruction of veins or arteries, a condition called thrombosis. Blocking the activity of this compound, polyphosphate, could treat thrombosis with fewer bleeding side effects than the drugs that are currently on the market. Their findings appear in the journal Blood. Blood clots are formed at the site of an injured blood vessel to prevent blood loss. Sometimes, however, ...

To build the computer chips of the future, designers will need to understand how an electrical charge behaves when it is confined to metal wires only a few atom-widths in diameter. Now, a team of physicists at McGill University, in collaboration with researchers at General Motors R&D, have shown that electrical current may be drastically reduced when wires from two dissimilar metals meet. The surprisingly sharp reduction in current reveals a significant challenge that could shape material choices and device design in the emerging field of nanoelectronics. The size of ...

MINNEAPOLIS, MN – November 5, 2012 – A multicenter registry has demonstrated that the use of implantable cardioverter-defibrillators (ICDs) to combat sudden cardiac death in high-risk pediatric patients suffering from hypertrophic cardiomyopathy (HCM). The study is being presented Nov. 5 at the 2012 Scientific Sessions of the American Heart Association (AHA) in Los Angeles. While the study found that the rate of possible device complications adds a level of complexity to this age group, it also demonstrated that life-saving ICD interventions were common in younger patients ...