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Glioblastoma is the most common and most lethal form of brain tumor in people. Research published in the International Journal of Computational Biology and Drug Design offers a novel way to determine what biological functions go awry when the tumor first begins to form. Understanding the problems at the molecular level might one day reveal the underlying mechanism of carcinogenesis in glioblastoma and ultimately lead to treatments or even preventative measures. This form of brain tumor account for more than half of all cases in which the tumor is within the tissues of ...

Researchers from the RUB-Department of Biophysics of Prof. Dr. Klaus Gerwert have succeeded in providing evidence that a protein is capable of creating a water molecule chain for a few milliseconds for the directed proton transfer. The combination of vibrational spectroscopy and biomolecular simulations enabled the elucidation of the proton pump mechanism of a cell-membrane protein in atomic detail. The researchers demonstrated that protein-bound water molecules play a decisive role in the function. Their results were selected for the Early Edition of PNAS. Protein-bound ...

Modern women are still heavily influenced by the idealised love and sex, purveyed by romantic fiction, says broadcaster and agony aunt Susan Quilliam in this month's Journal of Family Planning and Reproductive Health Care. In some parts of the developed world, romance accounts for nearly half of all fiction titles purchased. And while there is clearly a place for the genre, which can be enjoyable and fun, this rose-tinted view of relationships is not necessarily doing women any favours, argues Ms Quilliam. "I would argue that a huge number of the issues we see in ...

Online retailer HMV revealed their most popular CDs, DVDs and video game titles available for pre-order and release during the summer through their online store at www.hmv.com. Music Beyonce 4 - Release date: 27th June 2011 Hot on the heals of her Glastonbury festival headline set the superstar singer releases her latest album titled '4' featuring the single 'Run The World (Girls)'. Cher Lloyd Album - Release date: 7th November 2011 The album release has been pushed back until November but that doesn't stop the X factor star from making a big impact on the ...

Probiotics, as functional supplements, are good for both the immune system and for intestinal health. But how do they get into the yoghurt jar? So far, probiotic bacteria are mostly freeze-dried, before they are used in high concentrations in foods. However, the freeze-drying process is problematic – for some probiotics it means certain death, and it is also quite energy consuming. The probiotics must first be frozen and in a second step heat is inserted in the sample to transform the ice directly into steam. Thus water is removed from the bacterial culture. The TUM researchers ...

Geo-engineering schemes aimed at tackling global warming through artificial iron fertilisation of the oceans would significantly affect deep-sea ecosystems, according to research involving scientists from the United Kingdom's National Oceanography Centre (NOC) as well as former Ocean and Earth Science research students of the University of Southampton, which is based at the Centre. Most scientists believe that the rapid increase in atmospheric carbon dioxide resulting largely from the burning of fossil fuels is causing the world to warm up. One proposed geo-engineering ...

Built specifically to break the Charlie Barr Transatlantic Record by the French shipyard JMV Industries in 2003 this 43 metre, Philip Briand designed schooner was built to be at the forefront of her class. "She was designed to be the world's most cutting-edge racing schooner," says YPI Group CEO, Bertrand Vogele. "The goal was to beat the Charlie Barr Transatlantic Record for a monohull. In October 2003 she succeeded...smashing it by almost two days." The SENSO ONE still holds this record and also retains the records for the fastest crossing from ...

A new study by Katy Prentice, done as part of her undergraduate degree (MSci in Palaeontology and Evolution) at the University of Bristol, shows that the pterosaurs evolved in a most unusual way, becoming more and more specialised through their 160 million years on Earth. The work is published today in the Journal of Systematic Palaeontology. 'Usually, when a new group of animals or plants evolves, they quickly try out all the options. When we did this study, we thought pterosaurs would be the same,' said Katy. 'Pterosaurs were the first flying animals – they appeared ...

The research will be presented today [Thursday 7 July] at the Annual Scientific Meeting of the Society of Academic Primary Care, hosted this year by the Academic Unit of Primary Health Care, University of Bristol. The HPV vaccination programme, introduced in the UK in 2008, uses HPV vaccine that is effective against the two most common high risk HPV types (16 and 18), and offers 70 per cent protection against cervical cancer. However, vaccinated girls will still need to attend cervical screening in the future to ensure protection against cervical cancer caused by high ...

The research will be presented today [Thursday 7 July] at the Annual Scientific Meeting of the Society of Academic Primary Care, hosted this year by the Academic Unit of Primary Health Care, University of Bristol. The research was funded by the National Institute for Health Research (NIHR) School for Primary Care Research (NSPCR). Dr Susannah Fleming and colleagues used a dataset containing heart rate, temperature, and oxygen saturation measurements from 873 children, and assessed the severity of their illness by checking whether they were admitted to hospital in the ...

Researchers at the Georgia Institute of Technology have designed a multiple-compartment gel capsule that could be used to simultaneously deliver drugs of different types. The researchers used a simple "one-pot" method to prepare the hydrogel capsules, which measure less than one micron. The capsule's structure -- hollow except for polymer chains tethered to the interior of the shell -- provides spatially-segregated compartments that make it a good candidate for multi-drug encapsulation and release strategies. The microcapsule could be used to simultaneously deliver distinct ...

Research from North Carolina State University shows that organized sports can be a powerful tool for helping to rebuild communities in the wake of disasters. The research focused specifically on the role of professional football in the wake of Hurricane Katrina. "Sports, and by extension sports media, can be a powerful force for good. It can bring people together. It can provide hope, even in the midst of great destruction," says Dr. Ken Zagacki, co-author of a paper describing the research and a professor of communication at NC State. "But we have to be careful that ...

SEO Specialist hear many small and medium sized companies complain about transparency in the online marketing industry. Not every SEO company reveal what's included in the services to make websites be found in top of Google, Yahoo and Bing. In an attempt to reveal what's included in SEO Specialist's services, a comprehensive guide to search engine optimisation (SEO) was released. The popular guide to SEO covers all areas of website optimisation and it is divided into four chapters; - SEO analysis: Discuss how to analyse a website and it's competitors. - On-Page ...

AUGUSTA, Ga. – Altering the body's metabolism could be an effective treatment for deadly liver cancer, researchers report. The finding that inhibiting heat shock transcription factor 1, or HSF1, prevents liver cancer in mice also is another wake-up call that a low-fat, healthy diet is an effective cancer deterrent, said Dr. Demetrius Moskophidis, Cancer Virologist/Immunologist at Georgia Health Sciences University. HSF1 and its target genes are important to metabolism regulation. "The principle that we demonstrated is that if we change the metabolism, we can interfere ...

River Nile Casino, a top online casino has reported an increase in payouts for the month of May, 2011. Payouts rose to 109.01% on Poker games. This ultimately means that more players won more during this period. Games at the casino are divided into four main categories, these being Table Games, Poker Games, Slot Games and Unique Games. Each category is monitored and analysed individually and reports are generated on each category for the casino by an independent auditing association. Once the reports are generated, the casino makes these public for all users to view ...

BOSTON – Astronauts lose a significant amount of bone mass during space travel and with long duration flights there is concern that this bone loss could lead to an increased risk of fractures. When the final mission of NASA's 30-year Space Shuttle program is launched on July 8, an animal experiment to test a novel therapy to increase bone mass will be on board. Led by a consortium of scientists from Beth Israel Deaconess Medical Center (BIDMC), Amgen, Inc., UCB, BioServe Space Technologies and the University of North Carolina, and funded by NASA's Ames Research Center, ...

The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X (u-EPX), a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years. The study appeared online in advance of the print publication of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. "We asked whether the allergic disease process may be active ...

Online Casino, Maple Casino has just reported paying out 100.15% during the month of May for Table Games. There are four main divisions in the casino gaming, and the other three also reported payouts in the high nineties. On a monthly basis, the casino payouts are independently audited and a report is compiled by a separate organization. This report has just been released by the casino, and payouts for May were running high! Casino Manager, Charlotte Jackson, said, "We are very proud to announce that our Table Game Payouts for May have peaked at 100.15%. This ...

Cambridge, Mass. – July 6, 2011 – By applying a coating to individual silicon nanowires, researchers at Harvard and Berkeley have significantly improved the materials' efficiency and sensitivity. The findings, published in the May 20, 2011, issue of Nano Letters, suggest that the coated wires hold promise for photodetectors and energy harvesting technologies like solar cells. Due to a large surface-to-volume ratio, nanowires typically suffer from a high surface recombination rate, meaning that photogenerated charges recombine rather than being collected at the terminals. ...

MadCap Software, Inc. (http://www.madcapsoftware.com), the leader in multi-channel content authoring and a showcase company for Microsoft Visual Studio and Microsoft XPS, today announced that MadCap Feedback Server 4.0 is now available. MadCap Feedback Server 4.0 (http://www.madcapsoftware.com/products/feedback/overview.aspx#introduction) is a server-based feedback system for content development teams that provides Web 2.0 features--such as blog-style comments and topic rating--to capture readers' insights and opinions on content such as knowledge bases, online Help, ...

Top-performing hospitals are typically ones headed by a medical doctor rather than a manager. That is the finding from a new study of what makes a good hospital. The research, to be published in the elite journal Social Science and Medicine, is the first of its kind. Its conclusions run counter to a modern trend across the western world to put generally trained managers -- not those with a medical degree -- at the helm of hospitals. This trend has been questioned, particularly by the Darzi Report, which was commissioned by the U.K. National Health Service, but until ...

MANHATTAN, Kan. -- By mapping various genomes onto an X-Y axis, a team comprised mostly of Kansas State University researchers has found that Charles Darwin and a fruit fly -- among other organisms -- have a lot in common genetically. Their discovery, "Chromosome Size in Diploid Eukaryotic Species Centers on the Average Length with a Conserved Boundary," was recently published in the journal Molecular Biology and Evolution. It details a project that compared 886 chromosomes in 68 random species of eukaryotes -- organisms whose cells contain a nucleus and are enclosed ...

The largest digital camera ever built for a space mission has been painstakingly mosaicked together from 106 separate electronic detectors. The resulting "billion-pixel array" will serve as the super-sensitive 'eye' of ESA's Galaxy-mapping Gaia mission. While the naked human eye can see several thousand stars on a clear night, Gaia will map a billion stars within our own Milky Way Galaxy and its neighbours over the course of its five-year mission from 2013, charting their brightness and spectral characteristics along with their three-dimensional positions and motions. In ...

An Ohio women and her husband recently settled a lawsuit against a Toledo area hospital for injuries suffered in a post-surgery fall soon after undergoing a knee arthroplasty procedure at said hospital. The fall led to an array of physical complications for the woman, who almost needed to amputate her leg to survive post-surgery complications stemming from the accident. According to the complaint filed in the Court of Common Pleas, Lucas County, Ohio, the patient was left unattended, out of her hospital bed, less than two hours after her reconstructive knee surgery; ...