For some leukemia patients, the only potential chemotherapy option is a drug that also carries a high risk of heart failure. This means that some patients who recover from their cancer will end up dying of heart disease brought on by the cure. In a new study, researchers from the University of Illinois Chicago and other universities have identified mechanisms that cause the drug, ponatinib, to harm the heart. They also identified a promising treatment that could reverse this process. The paper, with senior author Sang Ging Ong, assistant professor of pharmacology and medicine at UIC, is published in Circulation Research. The study is part of a growing field called cardio-oncology ...

UC Riverside scientists have discovered a tiny worm species that infects and kills insects. These worms, called nematodes, could control crop pests in warm, humid places where other beneficial nematodes are currently unable to thrive. This new species is a member of a family of nematodes called Steinernema that have long been used in agriculture to control insect parasites without pesticides. Steinernema are not harmful to humans or other mammals and were first discovered in the 1920s.  “We spray trillions of them on crops every year, and they’re ...

In a study that signals potential reproductive and health complications in humans, now and for future generations, researchers from McGill University, the University of Pretoria, Université Laval, Aarhus University, and the University of Copenhagen, have concluded that fathers exposed to environmental toxins, notably DDT, may produce sperm with health consequences for their children. The decade-long research project examined the impact of DDT on the sperm epigenome of South African Vhavenda and Greenlandic ...

UPTON, NY—Biologists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory have demonstrated a new way to boost the oil content of plant leaves and seeds. As described in the journal New Phytologist, the scientists identified and successfully altered key portions of a protein that protects newly synthesized oil droplets. The genetic alterations essentially protect the oil-protector protein so more oil can accumulate. “Implementing this strategy in bioenergy or oil crop plants could ...

Québec, February 8, 2024 - Contrary to popular belief, the benefits of physical activity do not outweigh the risks of cardiovascular disease associated with drinking sugar-sweetened beverages, according to a new study led by Harvard T. H. Chan School of Public Health. Jean-Philippe Drouin-Chartier, professor at Université Laval’s Faculty of Pharmacy, was a co-author.   Sugar-sweetened beverages are the largest source of added sugars in the North American diet. Their consumption is associated with ...

(BOSTON: Thursday, February 8, 2024) – Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) will award up to US$1.8 million to biotechnology company, Visby Medical, to develop a portable rapid polymerase chain reaction (PCR) diagnostic to detect the presence of the pathogen that causes gonorrhea, Neisseria gonorrhoeae (NG), and its susceptibility to ciprofloxacin, a former frontline oral antibiotic that can no longer treat resistant NG. A rapid result on when ciprofloxacin may be effective could enable physicians to treat gonorrhea patients with confidence, while reserving ceftriaxone, the only antibiotic that remains effective against resistant NG. Visby ...

GARCHING and OXFORD (8 February 2024) – The Joint European Torus (JET), one of the world’s largest and most powerful fusion machines, has demonstrated the ability to reliably generate fusion energy, whilst simultaneously setting a world-record in energy output. These notable accomplishments represent a significant milestone in the field of fusion science and engineering. In JET's final deuterium-tritium experiments (DTE3), high fusion power was consistently produced for 5 seconds, resulting in a ground-breaking record of 69 megajoules using a mere 0.2 milligrams of fuel. JET is a tokamak, a design which uses powerful ...

Electronically conducting two-dimensional (2D) materials are currently hot topics of research in both physics and chemistry owing to their unique properties that have the potential to open up new avenues in science and technology. Moreover, the combination of different 2D materials, called heterostructures, expands the diversity of their electrical, photochemical, and magnetic properties. This can lead to innovative electronic devices not achievable with a single material alone. Heterostructures can be fabricated in two ways: vertically, with materials ...

An eye-catching new study shows just how different the experience of walking home at night is for women versus men. The study, led by Brigham Young University public health professor Robbie Chaney, provides clear visual evidence of the constant environmental scanning women conduct as they walk in the dark, a safety consideration the study shows is unique to their experience. Chaney and co-authors Alyssa Baer and Ida Tovar showed pictures of campus areas at four Utah universities — Utah Valley University, ...

Researchers from the University of Cambridge and the British Antarctic Survey have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 metres — that’s more than the height of the Empire State Building — in just under 200 years. This is the first evidence anywhere in Antarctica for such a fast loss of ice. Scientists are worried that today’s rising temperatures ...

LA JOLLA (February 8, 2024)—Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell’s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where it belongs (inside of mitochondria), it sustains both mitochondrial and cellular health—but when it goes where it doesn’t belong, it can initiate an immune response that promotes inflammation. Now, Salk scientists ...

Researchers from Tokyo Medical and Dental University (TMDU) overcome scientific roadblocks and develop a model to assess the biology of the human placental barrier Tokyo, Japan – During pregnancy, the human placenta plays multiple essential roles, including hormone production and nutrient/waste processing. It also serves as a barrier to protect the developing fetus from external toxic substances. However, the placental barrier can still be breached by certain drugs. In a recent article published in Nature Communications, a team led by researchers ...

Under strict embargo until 10.00 GMT Thursday 8 February 2024   A new King’s College London scanning study of 390 babies has shown distinct patterns between term and pre-term babies in the moment-to-moment activity and connectivity of brain networks. Supported by Wellcome and the National institute of Health and Care Research (NIHR) Maudsley Biomedical Research Centre, this is the first study to analyse how the communication between brain areas changes moment-to-moment in the first few weeks of life. Published in Nature Communications, the study also found that these dynamic ...

White actors are featured more frequently and more prominently on posters for American-produced films than non-white actors despite recent increases in the representation of actors from other ethnic groups, according to a study published in Humanities and Social Sciences Communications. Galit Fuhrmann Alpert and colleagues investigated trends in the ethnic diversity of actors featured on over 45,000 posters advertising over 24,000 English-speaking films produced in the USA between 1960 and 2021.  Actors were assigned to one of four ethnic groups; white, Black, Indian, or Asian using an algorithm trained on the FairFace image dataset, which contains equal numbers ...

Francis Crick Institute press release Under strict embargo: 01:00hrs GMT Thursday 8 February 2024 Peer reviewed  Experimental study  Animals and cells  Researchers identify potential way to treat genetic epilepsy by replacing ‘lost’ enzyme Scientists at the Francis Crick Institute have found a new treatment target for CDKL5 deficiency disorder (CDD), one of the most common types of genetic epilepsy.  CDD causes seizures and impaired development in children, and medications are limited to managing symptoms rather than tackling the root cause of the disease. The disorder involves losing the function of a gene producing the CDKL5 enzyme, which ...

New guidelines for reporting clinical trials of biofield therapies are presented in the peer-reviewed Journal of Integrative and Complementary Medicine (JICM). Biofield therapies (BFTs), such as External Qigong, Healing Touch, Reiki, and Therapeutic Touch, are a related group of integrative medicine interventions in which practitioners use their hands on or above a client’s body to stimulate healing and well-being. Click here to read the article now. The guidelines call for including details of the intervention protocols relevant to biofield therapy trials. The Reporting Evidence Guidelines comprises ...

DETROIT– A team of researchers from Wayne State University was awarded a $1.4 million, three-year grant from the U.S. Department of Defense for the study, “Cytochrome c acetylation drives prostate cancer aggressiveness and Warburg effect.” The study, led by Maik Hüttemann, Ph.D., professor of molecular medicine and genetics, and biochemistry, microbiology and immunology at Wayne State University’s School of Medicine, aims to establish the role of the protein cytochrome c, which the team proposes is ...

Australian geologists have used plate tectonic modelling to determine what most likely caused an extreme ice-age climate in Earth’s history, more than 700 million years ago. The study, published in Geology, helps our understanding of the functioning of the Earth's built-in thermostat that prevents the Earth from getting stuck in overheating mode. It also shows how sensitive global climate is to atmospheric carbon concentration. “Imagine the Earth almost completely frozen over,” said the study’s lead author, ARC Future Fellow ...

A person’s chance of surviving while receiving cardiopulmonary resuscitation (CPR) for cardiac arrest in hospital declines rapidly from 22% after one minute to less than 1% after 39 minutes, finds a US study published by The BMJ today. Similarly, the likelihood of leaving hospital with no major brain damage declines from 15% after one minute of CPR to less than 1% after 32 minutes with no heartbeat. The researchers say the findings provide insights that may help guide hospital teams, patients and their families in deciding how long to continue resuscitation. In-hospital ...

An online programme of physical and mental health rehabilitation can improve quality of life for adults with long covid, finds a trial published by The BMJ today. The eight week REGAIN programme, delivered in online group sessions, led to sustained improvements in fatigue, pain, and depression compared with usual care. The researchers say this accessible, resource-efficient programme can be delivered at scale and will assist clinicians in the treatment of this complex condition. Post-covid-19 condition (commonly known as long covid) ...

The anxiety of headteachers across England increased “substantially” throughout the pandemic, finds the largest study of its type to-date. The results of the research, which examined thousands of teachers’ anxiety about work at 75 touchpoints from October 2019 to July 2022, show that senior leaders in schools suffered – even “much more” when compared with junior colleagues. The findings, published today in the peer-reviewed journal Educational Review, are the latest to demonstrate the mental ...

A life-threatening mold infection known as health care-associated Fusarium solani meningitis can be associated with a delayed, but devastating, injury to the brainstem and its blood supply among those infected, according to physicians from UTHealth Houston. A report, led by first author Nora Strong, MD, and senior author Luis Ostrosky-Zeichner, MD, was published today in the New England Journal of Medicine. Strong is a second-year postdoctoral fellow in infectious diseases with McGovern Medical ...

Study effectively reduced doctors’ actions for overused tests and treatment Routine testing for prostate cancer, urinary tract infections and blood sugar can result in unnecessary care and serious health problems  Practices stubbornly persist despite lack of evidence  CHICAGO --- When a doctor ordered a routine prostate screening for an 80-year-old man — as doctors often do — a dramatic yellow alert popped up on the electronic health record with dire warnings.  It flashed: “You are ordering a test that no guideline ...

If you’re pregnant, you may want to think twice before making a hamburger run or reaching for a prepackaged pastry, according to research published last month in the journal Environmental International.  Oddly enough it’s not the food that the report targets — not the fries, burgers or even the shakes and cakes — but what touches the food before you eat it.  Research shows that phthalates, a class of chemicals associated with plastics, can shed from the wrapping, packaging and even from plastic gloves worn by food handlers into food. Once consumed during pregnancy, the chemicals can get into the bloodstream, through ...

The U.S. Department of Defense (DoD) awarded a $5 million grant to the University of Texas Rio Grande Valley (UTRGV)-led America’s Additive Foundry Consortium, which includes the University of Houston as a key partner. This is one of six grants – totaling about $30 million – to help enhance national security through community investments. The funding will enable the consortium to undertake a $7.5 million project designed to ensure that the U.S. military has a stable supply of domestically produced, high-quality tactical alloys critical for national defense. The ...