LA JOLLA, CA – January 18, 2011 – Using chemical compounds found in a Japanese plant as a lead and the clever application of ultraviolet light, a Scripps Research Institute team has created a unique library of dozens of synthetic compounds to test for biomedical potential. Already, one of the compounds has shown great promise in inhibiting replication of HIV particles and fighting inflammation. With the report of their work scheduled to appear in the online Early Edition of Proceedings of the National Academy of Sciences this week, the researchers now plan to optimize ...

CHAMPAIGN, Ill. — Researchers have determined the structure and mechanism of an enzyme that performs the crucial first step in the formation of cholesterol and a key virulence factor in staph bacteria. Chemists at the University of Illinois and collaborators in Taiwan studied a type of enzyme found in humans, plants, fungi, parasites, and many bacteria that begins the synthesis of triterpenes – one of the most abundant and most ancient classes of molecules. Triterpenes are precursors to steroids such as cholesterol. "These enzymes are important drug targets," said chemistry ...

While every cell of an organism contains the same genes only a proportion are expressed in any tissue at a given stage in development. Knowing the extent of gene transcription is valuable and a team of European researchers has generated an atlas of gene expression for the developing mouse embryo. This will be a powerful resource to determine co-expression of genes and to identify functional associations between genes relevant to development and disease. The findings will be published next week in the online, open access journal PLoS Biology. The comprehensive, interactive ...

Severe asthma in early childhood may lead to premature loss of lung function during adolescence and more serious disease during adulthood, researchers at Emory University School of Medicine report. Early identification and treatment of children with severe asthma is important to help stem asthma progression. In an article available online in the January issue of the Journal of Allergy and Clinical Immunology at http://www.jacionline.org/article/S0091-6749%2810%2901651-9/fulltext, Anne M. Fitzpatrick, PhD, and W. Gerald Teague, MD, and colleagues report on their study of ...

A new study at Rochester Institute of Technology indicates that the incidence of maltreatment, including neglect and physical and sexual abuse, is more than 25 percent higher among deaf and hard-of-hearing children than among hearing youths. The research also shows a direct correlation between childhood maltreatment and higher rates of negative cognition, depression and post-traumatic stress in adulthood. The study, which was presented at the 2010 annual meeting of the Association of Behavioral and Cognitive Therapies, is one of the first to compare childhood maltreatment ...

We all want an apology when someone does us wrong. But a new study, published in Psychological Science, a journal of the Association for Psychological Science, finds that people aren't very good at predicting how much they'll value an apology. Apologies have been in the news a lot the last few years in the context of the financial crisis, says David De Cremer of Erasmus University in the Netherlands. He cowrote the study with Chris Reinders Folmer of Erasmus University and Madan M. Pillutla of London Business School. "Banks didn't want to apologize because they didn't ...

COLUMBIA, Mo. – Frigid weather may seem like a good excuse to avoid workouts, stay inside and overindulge in comfort foods. However, health experts from the University of Missouri have found that these tendencies leave most people feeling less content during the winter months. MU researchers say people should establish new traditions to increase happiness and avoid wintertime woes. Instead of resolving to make drastic new year changes, establish healthy traditions for the winter months, MU nutrition and exercise physiology experts recommend. Incorporate activities ...

The newly released 2011 Thomson Reuters - HCPlexus National Physicians Survey (NPS) links doctors' fears that their pay will go down under the Patient Protection and Affordable Care Act (PPACA), commonly called Healthcare Reform Act (HCRA), with their concerns that the quality of care will also deteriorate. The study includes responses from 2,958 doctors of varying specialties and practice types, from all 50 states plus the District of Columbia. The NPS is the most comprehensive survey of physicians surrounding their thoughts on the future of healthcare, including ideas ...

Atrazine is one of the most widely used herbicides in North American corn production, but heated controversy remains over the 50-plus-year-old product. Several other herbicides are used in corn production, and a host of non-chemical tactics are sometimes used, too. If the use of atrazine is restricted or banned altogether, how will sweet corn growers cope? A recent University of Illinois study shows sweet corn can be grown successfully without atrazine, but given today's approach, perhaps not very often. "We wanted to know the implications of using less atrazine in current ...

LA JOLLA, CA—Mutant presenilin is infamous for its role in the most aggressive form of Alzheimer's disease—early-onset familial Alzheimer's—which can strike people as early as their 30s. In their latest study, researchers at the Salk Institute uncovered presenilin's productive side: It helps embryonic motor neurons navigate the maze of chemical cues that pull, push and hem them in on their way to their proper targets. Without it, budding motor neurons misread their guidance signals and get stuck in the spinal cord. By putting genes associated with Alzheimer's disease ...

ANN ARBOR, Mich.---The decreases in Earth's snow and ice cover over the past 30 years have exacerbated global warming more than models predict they should have, on average, new research from the University of Michigan shows. To conduct this study, Mark Flanner, assistant professor in the Department of Atmospheric, Oceanic and Space Sciences, analyzed satellite data showing snow and ice during the past three decades in the Northern Hemisphere, which holds the majority of the planet's frozen surface area. The research is newly published online in Nature Geoscience. Snow ...

Convalescent plasma therapy—using plasma from patients who have recovered from an infection to treat those with the same infection—has been used to treat multiple diseases. However, the efficacy of this treatment in patients with severe 2009 H1N1 influenza is unknown. A study published in the February 15 issue of Clinical Infectious Diseases suggests that convalescent plasma may reduce the death rate in patients severely ill with this type of influenza. (Please see below for a link to the embargoed study online.) From September 2009 through June 2010, patients from ...

ZapitSMS, the worldwide PC to Mobile text messaging provider has introduced the Bulk messaging feature to their Online SMS services. The new feature allows corporate, educational institutions and individual clients to send Bulk SMS from any PC connected to internet. Race River Corporation, the developer of ZapitSMS has announced the new feature for sending Bulk SMS via ZapitSMS Web-Admin. The recently added feature is simple to use and now available through ZapitSMS Web Admin. The ZapitSMS system allows uploading list of contact details using CSV file and creating message ...

MyBinding,com, a division of Information Management Services, LCC, recently announced the promotion of Jeff McRitchie from Director to Vice-President of Marketing MyBinding.com, one of the country's leading online retailers of document finishing equipment and supplies, recently announced that Jeff McRitchie, the company's Director of Marketing, has been promoted. McRitchie is now serving as the Vice-President of Marketing. "We are proud of Jeff and all that he's done for the company," said Cory Ware, co-owner of the company. "He's been a real asset to us and it seemed ...

The Managing Director Steve Fitzpatrick this week has revealed a history of building tender prices on the latest building projects managed by Your Building Broker with astonishing results. Home Buyers are expected to save huge amounts of money on their home building project by working with Your Building Broker instead of the old fashioned methods of going directly to a home builder or Architect designer. Your Building Broker was formed in 2010 as the building industry in Perth Western Australia was becoming insular with land sales agents doing deals with large building ...

Luigi's Tahoe Pizzeria is now open and serving up the finest ( http://www.pizzalaketahoe.com/ ) pizza in South Lake Tahoe, Nevada. Luigi's one-of-a-kind staff is committed and dedicated to making your dining experience one with variety while being cost affordable in an inviting environment. In addition to ( http://www.pizzalaketahoe.com/ ) pizza, Luigi's serves up your favorite salads, sandwiches, desserts and wide selection of amazing beers. If beer is not of your tasting, their selection of California and Italian wines is sure to satisfy your lunch or dinner craving. ...

Join Jennifer Longmore, North America's Soul Purpose Expert, as she hosts 11 Global Spiritual Leaders where they will each share their wisdom and expertise to help you fully step into your greatness and make YOUR mark on the world. From February 7th to February 21st, you will get access to these world-class leaders: • Star Ladin • Marsh Engle • Joanna Garzilli • Heather Dominick • Jacqueline Joy • Madeleine Marentette • Amanda Moxley • Laura Hollick • Amethyst Wyldfyre • Jessica Eaves Mathews • Linda P. Jones • Jennifer Longmore These powerful guides are ...

TonerGreen, the online printer supply store that offers eco-friendly, U.S.-made and non-patent infringing ink and toner cartridges, has been given the Green America Business Seal of Approval to certify its commitment in providing not just eco-friendly printing solutions but also in social and environmental responsibility. Green America's Green Business Network is the first and one of the most reliable networks for all businesses that are both active in giving socially and in offering nature-friendly services. As a non-profit organization that aims to bring together green ...

UniversalAutoTransport.com, a site that provides auto shipping quotes and transportation advice as well as information on individual state driving laws, was founded 11 years ago and has served customers through several incarnations. On 1/11/2011, UAT affirms its commitment to providing timely shipping and transportation news roundups, as well. The website's aim is to become a clearinghouse for the automobile transportation industry, which has experienced impressive growth in the past several years, and today includes many thousands of small and medium operators and entrepreneurs. ...

The New Year often brings the desire to make changes for the better, and VisionBedding makes that much easier this year with a unique line of bedding and accessories suitable for even the most creative individual. Dubbed "funky bedding ( http://www.visionbedding.com/Bedding/funky.php ) & decor," the new line was unveiled late last year at the overwhelming suggestion of customers. "We routinely turn to our customers to develop new styles," said Justin Poile, Founder and CEO of VisionBedding. "The funky decor took us by surprise, but once we looked at the idea, we decided ...

It's no secret that the mobile industry is surging at an astronomical rate. According to a report by GetJar, the industry will be worth $17.5 billion by 2012. Make no mistake, this is an industry being driven by apps that sell for between $0.99 and $2.99 on average. The industry as such has attracted capital investment as well as growing exposure in popular culture. GetJar estimates that mobile phone users will download approximately 50 billion applications in 2012 (majority of them being free apps of course) which is a 92% yer over year growth rate from the 7 billion ...

Good Feet , a custom fit arch support retailer launches its third round of their Feel Good Sweepstakes. For the month of January, the sweepstakes offers weekly giveaways for a pair of Good Feet Custom Fit Arch Supports. With over a 2,000 entries thus far, the sweepstakes has already reached great popularity. Sweepstakes entries can be submitted on the Good Feet website or Facebook page now through the end of January. Contestants are also encouraged to "Like" the Good Feet Facebook page or "Follow" Good Feet on Twitter (@MrGoodFeet) to stay updated on contest news and winners. According ...

The CIO Canada Summit team announced today that Canadian CIOs and senior technology executives are invited to qualify as speakers for the upcoming event to be held February 27 - March 2, 2011 at the Fairmont The Queen Elizabeth in Montreal, QC. The CIO Canada Summit will bring together CIOs, technology analysts and solution providers to discuss the latest IT topics and trends. The event's agenda features think tanks, analysts Q&A sessions, roundtables and open forums, and is designed to encourage in-depth conversation and idea sharing among the event's attendees. Current ...

NAAFA is pleased to announce that we will be returning to the Washington, DC area for our 2011 annual fund raising convention. Make plans now to join us at The Westin Washington Dulles Airport. Room rates are a super low $79 per night and can be booked for Thursday, Aug 4, 2011 - Monday, August 8, 2011! The Westin is prepared to receive your NAAFA convention reservations today at: http://www.starwoodmeeting.com/StarGroupsWeb/booking/reservation?id=1101116740&key=4FB52 We have worked hard to keep the cost of this convention down and to get the lowest hotel prices we ...

The Advanced Google AdWords training course in Perth is a half day course that is designed as an advanced course for those businesses that have some experience with setting up or running a Google AdWords campaign, but want to get better results from their spend. It will cover such areas as advanced campaign settings and structure, keyword targeting, writing effective adverts, bid management techniques, the use of landing pages and conversion tracking. There is also a full day training course taking place on the previous day, Thursday 10th March, which is designed for ...