Socioeconomic factors such as education, occupation, and wealth influence the likelihood of developing cognitive impairment or dementia in later life and whether a person is likely to recover, finds a new study led by UCL researchers. The research, published in Scientific Reports, followed 8,442 adults aged 50 and above in England over 10 years from 2008/09 to 2018/19, to examine how socioeconomic factors at the start of the study were associated with changes in cognitive status. The researchers tracked how these people moved between various states: healthy, mild cognitive impairment, and dementia. They also considered the possibility ...

Getting to the heart of causality is central to understanding the world around us. What causes one variable — be it a biological species, a voting region, a company stock, or a local climate — to shift from one state to another can inform how we might shape that variable in the future.  But tracing an effect to its root cause can quickly become intractable in real-world systems, where many variables can converge, confound, and cloud over any causal links.  Now, a team of MIT engineers hopes to provide some clarity in the pursuit of causality. They developed ...

About The Study: This article discusses a recent revision of the Alzheimer Association criteria to define Alzheimer disease (AD) as a purely biological entity, which raises concerns that if diagnosis of AD can be reduced to the sole presence of AD core 1 biomarkers, major uncertainty and variability in the clinical prognosis of patients diagnosed with AD may be introduced. Corresponding Author: To contact the corresponding author, Bruno Dubois, MD, MSc, email bruno.dubois@aphp.fr. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaneurol.2024.3770) Editor’s ...

The EULAR 2025 Congress will gather the world's foremost rheumatology experts, fostering a unique environment to explore pioneering research, clinical advancements, and patient-centred innovations in rheumatology. This annual flagship event offers unparalleled access to transformative discussions and showcases the latest strides in patient care for rheumatic and musculoskeletal diseases (RMDs).    This year's Congress programme promises an impressive line-up, featuring must-see scientific sessions, EULAR Recommendations, and insightful abstract presentations. Esteemed speakers from across Europe and beyond ...

NEW YORK, November 1, 2024 — Newly published research in the journal Glia has identified crucial links between dietary choices and the progression of multiple sclerosis (MS). The study, led by Patrizia Casaccia, founding director of the Advanced Science Research Center at the CUNY Graduate Center’s (CUNY ASRC) Neuroscience Initiative and Einstein Professor of Biology and Biochemistry at the CUNY Graduate Center, explored how enzymes called ceramide synthase 5 and 6 are responsible for the toxic effect ...

With the rapid increase in the global population, a "protein crisis" is expected in the near future, where the supply of protein will not be able to meet the rising demand. Fishmeal is the most common protein source that supports the production of livestock and aquaculture products, which are key protein sources for human consumption. However, global shortage of fishmeal and its rising prices have created an urgent need to find and secure an alternative protein source. Insects are gaining attention as novel protein sources ...

Most women use medication during pregnancy. Yet, selecting appropriate drugs and doses is challenging. In a new The Lancet article, physicians and researchers from the Radboud university medical center, Maastricht UMC+, Imperial College London, and the University of Liverpool introduce a shared decision-making approach combining ethical principles and a pregnant woman’s values with existing evidence. They use the example of sertraline, a commonly prescribed antidepressant in pregnancy, to illustrate the advocated decision-making process. Although pregnant women often need medication, data on drug safety and efficacy in pregnancy remains limited. Historically seen as vulnerable research ...

Summary: Texas Tech’s Natasja van Gestel has been named Station Science Leader by the National Science Foundation (NSF), enabling her to lead and coordinate research at Antarctica’s Palmer Station while advancing her work on climate change’s impact on glaciers. As a leader, she will oversee multiple scientific initiatives, manage resources and ensure compliance with the Antarctic Treaty’s regulations. Why This Matters: Climate Study: Her research contributes vital data on climate change effects in Antarctica, crucial for global climate assessments. International Collaboration: ...

A low-sugar diet in utero and in the first two years of life can meaningfully reduce the risk of chronic diseases in adulthood, a new study has found, providing compelling new evidence of the lifelong health effects of early-life sugar consumption. Published in Science, the study finds that children who experienced sugar restrictions during their first 1,000 days after conception had up to 35% lower risk of developing Type 2 diabetes and as much as 20% less risk of hypertension as adults. Low sugar intake by the mother prior to birth was enough to lower risks, but ...

New Orleans - Ochsner Health physicians Dr. Richard Zweifler and Dr. Joseph Tarsia are co-authors on a post hoc analysis carried out in the ARCADIA randomized clinical trial, comparing the effectiveness of apixaban versus aspirin in preventing adverse clinical outcomes in patients with a history of cancer and cryptogenic stroke. The research found no significant difference in the risk of major ischemic and hemorrhagic events between those taking apixaban and aspirin. The ...

Traditional solutions for sleep disorders, including medications and cognitive behavioral therapies, often provide insufficient relief for military personnel, a problem researchers from the University of Arizona College of Medicine – Tucson will be hoping to solve with a $3 million grant from the Department of Defense Congressionally Directed Medical Research Program. Sleep problems are among the top health concerns of military personnel, with an estimated 85% meeting criteria for a clinically relevant sleep ...

BALTIMORE, October 31, 2024— Kennedy Krieger Institute is proud to celebrate the 25th anniversary of the F.M. Kirby Research Center for Functional Brain Imaging at Kennedy Krieger Institute, a leader in advancements and research in understanding the human brain. Established in 1999 in partnership with Johns Hopkins University School of Medicine, the center has transformed neuroscience and medical imaging by developing cutting-edge magnetic resonance imaging (MRI) techniques that allow researchers to examine and measure brain function and structure ...

Researchers at the University of Arizona’s Mel and Enid Zuckerman College of Public Health received a $1.75 million Centers for Disease Control and Prevention grant to conduct a community-based, participatory research study designed to improve vaccine uptake in Arizona’s rural and border communities.  Vaccination is a highly effective public health intervention that saves millions of lives per year, yet vaccination rates have declined in recent years for a variety of reasons, ranging from safety concerns to religious and philosophical objections. “Vaccination is a cornerstone of public health,” said co-principal investigator Tomas ...

Macrophage cells are the immune system’s frontline soldiers, early on the scene to protect the body from foreign invaders. These cells answer the immune system's critical question for the rest of its troops: friend or foe?  As critical responders, macrophages can perceive helpful biotechnology as threats. If not created with the right materials or mechanical forces, these devices can trigger an immune response that can cause inflammation, scar tissue or device failure. But what is the right material or the right mechanical force? In a meta-analysis co-led ...

Beyond colorful coral reefs and diverse nearshore ecosystems, Pacific Ocean waters surrounding the Hawaiian Islands have comparatively little marine life and low biological productivity. New research published by University of Hawai‘i (UH) at Mānoa oceanographers showed that eddies on the leeward side of the Hawaiian Islands can supply nutrients, not only locally, but also to the opposite side of the island chain and stimulate blooms of phytoplankton, microscopic plant life that lives in the surface ocean.  The study, published in JGR Oceans, was selected by the American Geophysical Union’s editorial board as a featured article. “While ...

Rice University together with Baylor College of Medicine and the Houston Methodist Academic Institute has awarded seed grants in support of research on health equity and digital health. Spearheaded by Rice’s Educational and Research Initiatives for Collaborative Health (ENRICH) office in collaboration with the two partnering institutions in the Texas Medical Center (TMC), the seed grant opportunity followed the Health Equity Workshop hosted earlier this year by Rice’s Digital Health Initiative. “To achieve equitable health outcomes, a comprehensive approach is essential — one ...

While many people believe that poor sleep during pregnancy is inevitable, new research has determined that cognitive behavioral therapy for insomnia (CBTi) while pregnant can not only improve sleep patterns but also address postpartum depression. Researchers from UBC’s Okanagan and Vancouver campuses, as well as the University of Calgary, discovered that delivering CBTi during pregnancy significantly reduces postpartum depressive symptoms after a baby arrives. “Early intervention is crucial for infant and parental mental health,” says Dr. Elizabeth Keys, an Assistant Professor in UBCO’s School of Nursing and a study co-author. “Our research explores how addressing ...

When light conditions rapidly change, our eyes have to respond to this change in fractions of a second to maintain stable visual processing. This is necessary when, for example, we drive through a forest and thus move through alternating stretches of shadows and clear sunlight. "In situations like these, it is not enough for the photoreceptors to adapt, but an additional corrective mechanism is required," said Professor Marion Silies of Johannes Gutenberg University Mainz (JGU). "Earlier work undertaken by her research group had already demonstrated that such a corrective 'gain control' mechanism exists ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The scientific feat, which took more than a decade to complete, is published today in the journal Science. The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes – more than nine in ten – are edited by the spliceosome. Errors in the process are linked to a wide spectrum of diseases including most types of cancer, neurodegenerative conditions and genetic ...

An analysis of social media posts that mention food and beverage products finds that fast food restaurants and sugar sweetened beverages are the most common, with millions of posts reaching billions of users over the course of a year. The study, published in the open access journal PLOS Digital Health, highlights the sheer volume of content normalising unhealthy eating, and argues that policies are needed to protect young people in the digital food environment. Obesity is a health challenge around the world and food environments, including in the digital space, can influence ...

People with stronger autistic trails showed distinct exploration patterns and higher levels of persistence in a computer game, ultimately resulting in better performance than people with lower scores of autistic traits, according to a new study published this week in PLOS Computational Biology by Francesco Poli of Radboud Universiteit, the Netherlands, and colleagues. Scientists know that individuals display curiosity and explore their environments to learn. How a person selects what they want to explore plays a pivotal role in how they learn and research has shown that exploration levels are highly variable across ...

Key takeaways According to Bredt's rule, double bonds cannot exist at certain positions on organic molecules if the molecule's geometry deviates too far from what we learn in textbooks. This rule has constrained chemists for a century. A new paper in Science shows how to make molecules that violate Bredt’s rule, allowing chemists to find practical ways to make and use them in reactions. UCLA chemists have found a big problem with a fundamental rule of organic chemistry that has been around for 100 years — it’s ...

A single enzyme fine-tunes red and yellow pigments in parrots’ polychromatic plumage, according to a new study. The findings reveal new insights into the molecular mechanisms underlying the evolution and display of color variation in one of nature’s most colorful birds. Colors play a central role in ecological adaptation and communication in the natural world. This is particularly true for birds, which are especially notable among animals for their wide range of vibrant plumage colors and patterns. Among birds, ...

By blindfolding Kuhl's pipistrelle bats and tracking their movements with novel GPS technology, researchers show that the tiny creatures can navigate over several kilometers using only echolocation. The findings highlight the animal’s ability to create and use detailed mental acoustic maps of their surroundings. Echolocating bats are known for their ability to nimbly avoid obstacles and catch tiny prey using only sound. However, echolocation is short-ranged and highly directional, allowing for the detection of large objects within only a few dozen meters, limiting its effectiveness for navigation compared to other senses, like vision. ...

Early-life sugar restriction – beginning in utero – can protect against diabetes and hypertension later in life, according to a new study leveraging data from post-World War II sugar rationing in the United Kingdom. The findings highlight critical long-term health benefits from reduced sugar intake during the first 1000 days of life. The first 1000 days from conception – from gestation until age 2 – is a critical period for long-term health. Poor diet during this window has been linked to negative health outcomes in adulthood. Despite dietary guidelines recommending zero added sugar in early life, high sugar exposure is ...