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The jigglings and wigglings of atoms reveal key aspects of COVID-19 virulence evolution

The jigglings and wigglings of atoms reveal key aspects of COVID-19 virulence evolution
2023-11-27
Auburn, AL – Richard Feynman famously stated, “Everything that living things do can be understood in terms of the jigglings and wigglings of atoms.” This week, Nature Nanotechnology features a groundbreaking study that sheds new light on the evolution of the coronavirus and its variants of concern by analyzing the behavior of atoms in the proteins at the interface between the virus and humans. The paper, titled “Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern,” is the result of an international collaborative ...

UCF receives 3 minority serving institution awards to promote collaborations with NASA

2023-11-27
ORLANDO, Nov. 27, 2023 – Three research projects from the University of Central Florida have been selected for NASA Minority University Research and Education Project Partnership Annual Notification (MPLAN) awards. The grants, worth up to $50,000 each, are designed to connect and promote research collaborations between Minority Serving Institutions and NASA Mission Directorates. A total of 18 projects received Phase I funding across 15 universities. UCF received the most awards, with all three housed within the College of Engineering and Computer Science. Dean Michael Georgiopoulos ...

Stem cell-based treatment controls blood sugar in people with Type 1 diabetes

Stem cell-based treatment controls blood sugar in people with Type 1 diabetes
2023-11-27
An innovative stem cell-based treatment for Type 1 diabetes can meaningfully regulate blood glucose levels and reduce dependence on daily insulin injections, according to new clinical trial results from the University of British Columbia (UBC) and Vancouver Coastal Health (VCH). “This is a significant step toward a functional cure for Type 1 diabetes,” said Dr. David Thompson, principal investigator at the Vancouver trial site, clinical professor of endocrinology at UBC and director of the Vancouver General Hospital Diabetes Centre. ...

Wave Devouring Propulsion: a revolutionary green technology for maritime sustainability

2023-11-27
A new form of wave devouring propulsion (WDP) could power ships and help to cut greenhouse gas emissions in the maritime industry.   Academics from Cranfield University have worked on the concept of using wave energy for propulsion, and designed an inventive method of achieving greater thrust from the power of the waves by harnessing a vessel’s submerged flapping foils in an innovative way.   Inspiration from whale fins   Taking inspiration from the power of a whale's fins, the team studied the structure and movement of the tail fin to unravel how it effectively uses wave energy for propulsion. Through simulations and experiments, they developed ...

Algorithmic recommendation technology or human curation? Study of online news outlet in Germany suggests both

2023-11-27
Recommender systems are machine learning applications in online platforms that automate tasks historically done by people. In the news industry, recommender algorithms can assume the tasks of editors who select which news stories people see online, with the goal of increasing the number of clicks by users, but few studies have examined how the two compare. A new study examined how users of an online news outlet in Germany reacted to automated recommendations versus choices made by human editors. On average, the algorithm outperformed the person, but the person did better under certain conditions. The study’s authors suggest a combination of human curation and automated recommender ...

BU study finds breast density discussions with clinicians varied significantly by race/ethnicity and literacy level

2023-11-27
(Boston)—Breast density information aims to increase awareness of breast density and its risks and inform future breast screening decisions. Breast density notifications (BDN) advise women to discuss breast density with their clinicians, but prior research shows less than half of women in the general population have those conversations and little is known about the content of conversations that do occur.    A new study by researchers from Boston University Chobanian & Avedisian School ...

Alien haze, cooked in a lab, clears view to distant water worlds

Alien haze, cooked in a lab, clears view to distant water worlds
2023-11-27
Scientists have simulated conditions that allow hazy skies to form in water-rich exoplanets, a crucial step in determining how haziness muddles observations by ground and space telescopes. The research offers new tools to study the atmospheric chemistry of exoplanets and will help scientists model how water exoplanets form and evolve, findings that could help in the search for life beyond our solar system. “The big picture is whether there is life outside the solar system, but trying to answer that kind of question requires really detailed modeling of all different types, specifically in planets with lots of water,” said co-author ...

Deoxygenation levels similar to today’s played a major role in marine extinctions during major past climate change event

Deoxygenation levels similar to today’s played a major role in marine extinctions during major past climate change event
2023-11-27
Scientists have made a surprising discovery that sheds new light on the role that oceanic deoxygenation (anoxia) played in one of the most devastating extinction events in Earth’s history. Their finding has implications for current day ecosystems – and serves as a warning that marine environments are likely more fragile than apparent. New research, published today in leading international journal Nature Geosciences, suggests that oceanic anoxia played an important role in ecosystem disruption and extinctions in marine environments during the Triassic–Jurassic mass extinction, ...

Fish IgM structure sheds light on antibody evolution, study finds

Fish IgM structure sheds light on antibody evolution, study finds
2023-11-27
Antibodies—proteins that are produced by our immune system to protect us—are crucial for recognizing and getting rid of unwanted substances, or antigens, in our body. Although their role is universal, antibody structure varies in different animals. In a new study, researchers have analyzed the antibody Immunoglobulin M in rainbow trout to shed some light on why these proteins may have evolved over time. In humans, IgM consists of five repeating units that are held together by a joining chain, resulting in a star shape. Consequently, IgM can bind to multiple antigens at the ...

Wind and solar projects can profit from bitcoin mining

2023-11-27
ITHACA, N.Y. – Bitcoin mining is often perceived as environmentally damaging because it uses huge amounts of electricity to power its intensive computing needs, but a new study demonstrates how wind and solar projects can profit from bitcoin mining during the precommercial development phase — when a wind or solar farm is generating electricity, but has not yet been integrated into the grid. The findings suggest some developers could recoup millions of dollars to potentially invest in future renewable energy projects. The ...

Vampire bats make northward flight seeking stable climates

Vampire bats make northward flight seeking stable climates
2023-11-27
Vampire bats may soon take up residence in the United States and bring with them an ancient pathogen. “What we found was that the distribution of vampire bats has moved northward across time due to past climate change, which has corresponded with an increase in rabies cases in many Latin American countries,” said Paige Van de Vuurst, a Ph.D. student in Virginia Tech’s Translational Biology, Medicine, and Health Graduate Program.  Van de Vuurst is the lead author of research recently published in the Ecography journal that predicts ...

New method uses crowdsourced feedback to help train robots

2023-11-27
To teach an AI agent a new task, like how to open a kitchen cabinet, researchers often use reinforcement learning — a trial-and-error process where the agent is rewarded for taking actions that get it closer to the goal. In many instances, a human expert must carefully design a reward function, which is an incentive mechanism that gives the agent motivation to explore. The human expert must iteratively update that reward function as the agent explores and tries different actions. This can be time-consuming, inefficient, ...

Study shows price discounts on healthful foods like vegetables and zero-calorie beverages lead to an increase in consumption of these foods

Study shows price discounts on healthful foods like vegetables and zero-calorie beverages lead to an increase in consumption of these foods
2023-11-27
Dietary food intake has a major influence on health indicators, including Body Mass Index (BMI), blood pressure, serum cholesterol and glucose. Previous research has shown that decisions to purchase specific food items are primarily based on taste and cost. In the United States, only 12 percent and 10 percent of adults meet fruit and vegetable intake recommendations, respectively. Since affordability of food items is a limiting factor for meeting fruit and vegetable intake guidelines, researchers hypothesize that more affordable low energy-dense foods like fruits and vegetables, which are relatively more expensive ...

New platform solves key problems in targeted drug delivery

New platform solves key problems in targeted drug delivery
2023-11-27
In recent years, cell and gene therapies have shown significant promise for treating cancer, cystic fibrosis, diabetes, heart disease, HIV/AIDS and other difficult-to-treat diseases. But the lack of effective ways to deliver biological treatments into the body has posed a major barrier for bringing these new therapies to the market — and, ultimately, to the patients who need them most.   Now, Northwestern University synthetic biologists have developed a flexible new platform that solves part of this daunting delivery problem. Mimicking natural ...

Schrum and Sleeter unpacking the history of higher education in the United States

2023-11-27
Kelly Schrum, Professor, Higher Education Program; Affiliated Faculty, History and Art History, and Nathan Sleeter, Research Assistant Professor, History and Art History, Roy Rosenzweig Center for History and New Media (RRCHNM), received $220,000 from the National Endowment for the Humanities for the project: "Unpacking the History of Higher Education in the United States."  This funding began in Oct. 2023 and will end in late Dec. 2024.  The history of higher education is central to understanding its present and future, especially for students in Higher Education and Student Affairs (HESA) programs who will lead colleges and universities for decades ...

SwRI-led PUNCH mission advances toward 2025 launch

SwRI-led PUNCH mission advances toward 2025 launch
2023-11-27
SAN ANTONIO — November 27, 2023 —On November 17, 2023, the Polarimeter to UNify the Corona and Heliosphere (PUNCH) mission achieved an important milestone, passing its internal system integration review and clearing the mission to start integrating its four observatories. Southwest Research Institute leads PUNCH, a NASA Small Explorer (SMEX) mission that will integrate understanding of the Sun’s corona, the outer atmosphere visible during total solar eclipses, with the “solar wind” that fills and defines the solar system. SwRI is also building the spacecraft and three of its five instruments. “This ...

SMART researchers pave the way for faster and safer T-cell therapy through novel contamination-detection method

SMART researchers pave the way for faster and safer T-cell therapy through novel contamination-detection method
2023-11-27
Traditional sterility testing methods for the presence of bacteria and fungi in T-cell cultures are time-consuming, taking from seven up to 14 days, while this novel method takes only up to 24 hours Researchers combined advanced long-read nanopore sequencing techniques and machine learning to ensure accuracy and speed in detecting and identifying sample sterility status and microbial species present in T-cell cultures This breakthrough has the potential to transform sterility assurance in biopharmaceutical manufacturing, leading to better patient outcomes by accelerating the process of getting ...

AI may spare breast cancer patients unnecessary treatments

2023-11-27
·  AI tool could reduce disparities for patients who are diagnosed in community settings ·  Non-cancerous cells can play an important role in sustaining or inhibiting cancer growth  ·  One in eight U.S. women will receive a breast cancer diagnosis in her lifetime CHICAGO --- A new AI (Artificial Intelligence) tool may make it possible to spare breast cancer patients unnecessary chemotherapy treatments by using a more precise method of predicting their outcomes, reports ...

Characteristics and obtainment methods of firearms used in adolescent school shootings

2023-11-27
About The Study: School shooting incidents in the U.S. were typically executed using low- and moderate-powered firearms, according to this analysis of data from 262 adolescents who discharged firearms in 253 school shootings spanning 26 years. These weapons were most frequently stolen from family members or relatives of the perpetrators. These findings may significantly influence discussions around gun control policy, particularly in advocating for secure firearm storage to reduce adolescents’ access to weapons.  Authors: Brent R. Klein, Ph.D., of the University of South Carolina in Columbia, is the corresponding author. To access ...

Association of smoking cessation and cardiovascular, cancer, and respiratory mortality

2023-11-27
About The Study: Excess cardiovascular mortality among former smokers was about one-third that of continuing smokers within the first decade after quitting, and the cardiovascular mortality rate of former smokers was similar to that of never smokers 20 to 29 years after quitting in this study of 438,000 U.S. adults. These findings emphasize that with sustained cessation, cause-specific mortality rates among former smokers may eventually approximate those of never smokers.  Authors: Blake Thomson, D.Phil., of the Stanford University School of Medicine in Stanford, California, is the corresponding author. To access the embargoed study: Visit our For The Media website at ...

Brain boost: Can a coach help elders at risk for Alzheimer’s?

2023-11-27
Brain Boost: Can a Coach Help Elders at Risk for Alzheimer’s? Study shows cognitive improvements when participants keep active and socially engaged, control blood pressure and diabetes. As more medications move towards federal approval for Alzheimer’s disease, a new study led by researchers at UC San Francisco and Kaiser Permanente Washington has found that personalized health and lifestyle changes can delay or even prevent memory loss for higher-risk older adults. The two-year study compared cognitive ...

Early-stage stem cell therapy trial shows promise for treating progressive MS

2023-11-27
An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage. The study, led by scientists at the University of Cambridge, University of Milan Bicocca and Hospital Casa Sollievo della Sofferenza (Italy), is a step towards developing an advanced cell therapy treatment for progressive MS. Over 2 million people live with MS worldwide, ...

Irritability, agitation, and anxiety in Alzheimer’s patients caused by brain inflammation, study says

Irritability, agitation, and anxiety in Alzheimer’s patients caused by brain inflammation, study says
2023-11-27
PITTSBURGH, Nov. 27, 2023 – Common neuropsychiatric symptoms that doctors see in Alzheimer’s disease patients originate from brain inflammation rather than amyloid and tau proteins, report University of Pittsburgh School of Medicine researchers today in JAMA Network Open. The finding strengthens mounting evidence for the role of neuroinflammation in Alzheimer’s progression and suggests new pathways for the development of therapies targeting neurological symptoms of the disease. “Neuropsychiatric symptoms such as irritability, agitation, anxiety and depression are among the most difficult ...

Sensitive ecosystems at risk from mine waste

Sensitive ecosystems at risk from mine waste
2023-11-27
Nearly a third of the world’s mine tailings are stored within or near protected conservation areas, University of Queensland research has found. A study led by UQ’s Bora Aska, from the Sustainable Minerals Institute and School of the Environment, said these waste facilities pose an enormous risk to some of earth’s most precious species and landscapes. “Mine tailings contain the waste and residue that remains after mineral processing, and the storage facilities built to contain it are some of the world’s largest engineered structures,” Ms Aska said. “We found of the 1,721 disclosed tailings ...

Genes influence whether infants prefer to look at faces or non-social objects

Genes influence whether infants prefer to look at faces or non-social objects
2023-11-27
Whether infants at five months of age look mostly at faces or non-social objects such as cars or mobile phones is largely determined by genes. This has now been demonstrated by researchers at Uppsala University and Karolinska Institutet. The findings suggest that there is a biological basis for how infants create their unique visual experiences and which things they learn most about. The study has been published in the scientific journal Nature Human Behaviour. The way in which we explore our environment with our eyes affects what we notice, think about and learn. The new study analysed preference for faces versus non-social objects in ...
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