MINNEAPOLIS / ST. PAUL (03/12/2024) - Researchers at the University of Minnesota Twin Cities may have discovered a mechanical explanation for instability observed in the lungs in cases of acute respiratory distress syndrome (ARDS), particularly in the aftermath of respiratory illnesses such as COVID-19 or pneumonia. The research was recently published in the Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences. Currently, there is no known cure for ARDS, a life-threatening ...

Lignin is an abundant natural polymer which is eliminated as a byproduct in the pulp and paper industry. A recent review article explored different microbial processes available for sustainable lignin valorization, yielding not only environmental, but also economic benefits. Researchers highlighted the current advancements as well as challenges faced while using naturally occurring and engineered microbes to transform depolymerized lignin into valuable high-value products. The increasing focus on transitioning to a low-carbon ...

Given the worldwide prevalence of drug-resistance bacteria, the research fraternity is on the lookout for alternative bactericidal treatment approaches. In a recent study, Japanese researchers have now compared bacteriophage-derived enzymes for combating drug-resistant bacteria. Examination of T1-spanin revealed that it shows superior bactericidal activity against various strains, including E.coli. Furthermore, a novel phage-based technology effectively delivers T1-spanin genes into target bacteria. This breakthrough holds promise for the development of ...

From anxiety about the state of the world to ongoing waves of Covid-19, the stresses we face can seem relentless and even overwhelming. Worse, these stressors can cause chronic inflammation in our bodies. Chronic inflammation is linked to serious conditions such as cardiovascular disease and cancer – and may also affect our thinking and behavior.    A new hypothesis published in Frontiers in Science suggests the negative impacts may extend far further.    “We propose that stress, ...

LAWRENCE, KANSAS — A University of Kansas study of rice paddy snakes in Southeast Asia gives key details to their diversification and natural history, adding molecular evidence that the rise of the Khorat Plateau and subsequent environmental shifts in Thailand may have altered the course of the snakes’ evolution some 2.5 million years ago. The findings were published today in the journal Scientific Reports. Researchers say the implications could help tell the story of diversification more broadly in the region. “This paper concerns mud snakes ...

Scientists from the Universities of Sydney and Sorbonne University have used the geological record of the deep sea to discover a connection between the orbits of Earth and Mars, past global warming patterns and the speeding up of deep ocean circulation. They discovered a surprising 2.4-million-year cycle where deep currents wax and wane which, in turn, is linked to periods of increased solar energy and a warmer climate. The study, published in Nature Communications, tackles the questions of how geological-timescale climate ...

If you had to estimate the number of people in a room, without counting them one-by-one, by nature you would overcount them. That’s because, simply put from a Darwinian perspective of how we have evolved, it’s better to overcount potentially harmful agents and predators than to underestimate them. This overcounting social behaviour is shown to be true in humans as well as animals. It’s certainly better to detect too many tigers (even if absent) during a jungle excursion than to miss a hungry one! Now, EPFL neuroscientists show that if you experience hallucinations, especially ...

Researchers from China and Japan have discovered distinct characteristics of the lower mantle flow field. They investigated seismic anisotropy in the upper part of the lower mantle beneath the Philippine Sea Plate (PSP) and found that the ancient lower mantle flow field is still preserved there. The study was published in Nature Geoscience. The lower mantle is an important layer of the Earth and may play an important role in the evolution and material cycling of Earth's interior. It is generally believed to be not only the final destination of subducted slabs, ...

*EMBARGOED UNTIL TUESDAY, MARCH 12, AT 6 A.M. ET Age-related changes that cause the skin to stiffen and become less elastic may also contribute to higher rates of metastatic skin cancer in older people, according to research by investigators from the Johns Hopkins Kimmel Cancer Center.  The study, published March 12 in Nature Aging, shows that increased stiffness in aging skin increases the release of a protein called ICAM1. Increased ICAM1 levels stimulate blood vessel growth in the tumor, helping it grow. It also makes the blood vessels “leaky,” enabling tumor cells ...

Despite being scattered across more than a million square kilometres, new research has revealed that remote coral reefs across the Seychelles are closely related. Using genetic analyses and oceanographic modelling, researchers at Oxford University demonstrated for the first time that a network of ocean currents scatter significant numbers of larvae between these distant islands, acting as a ‘coral superhighway.’ These results are published today in Scientific Reports. Dr April Burt (Department of Biology, University of Oxford, and Seychelles Islands Foundation), lead author of the study, said: ‘This discovery is very important because a key factor ...

CAMBRIDGE, MA -- Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways — some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA. Until now, there has been no way to quickly and easily screen each of those mutations in their natural setting to see what role they may play in the development, progression, and treatment response of a tumor. Using a variant of CRISPR genome-editing known as prime editing, MIT researchers have ...

Rainforest seedlings are more likely to survive in natural forests than in places where logging has happened – even if tree restoration projects have taken place, new research shows. Scientists monitored over 5,000 seedlings for a year and a half in North Borneo. They studied a landscape containing both natural forest and areas logged 30 years ago – some of which were recovering naturally, while some had been restored by methods including tree planting. A drought had triggered “mast fruiting” across ...

More than 90% of the commercially available carotenoids are synthetically produced using chemicals. To meet the increasing demand for cost-effective natural compounds in carotenoid synthesis, researchers at Xiamen University, China, have developed an engineered S. cerevisiae yeast strain capable of selectively overproducing carotenoids. They redesigned the genomic sequence and critical pathways to optimize carotenoid production. This novel and successful research approach can be extended to other model ...

When we recycle electronic devices we can no longer use, we expect to make the most out of the precious natural resources that went into building them. But electronic waste is notoriously difficult to recycle, because it’s hard to separate the different metals in the waste from each other. Scientists have now found a way of selectively capturing metals from a waste stream using spent brewer’s yeast, the same beer byproduct that goes into Marmite. Not only that: the yeast can be reused, making the process even more eco-friendly. “Electronic waste is difficult to recycle because it is very heterogeneous,” said Dr Klemens Kremser ...

Does previous experience bias a person in future estimations? Yes, Osaka Metropolitan University researchers in Japan report, but only if the person engages higher processing powers by responding, as opposed to simply observing. They made their findings through experiments involving participants estimating the number of dots flashed on a screen. Participants either had to input their estimate before making another estimate on a new set of dots or were not prompted to do anything but observe. The researchers found ...

11 March 2024, Singapore – A study[1] by KK Women’s and Children’s Hospital (KKH), Singapore General Hospital (SGH) and National University Hospital (NUH) has revealed that  COVID-19 transmission from mothers to their newborns is low. The study involving 371 women who had COVID-19 infection during pregnancy and their newborns found that only four infants or 1.1 per cent of the babies were diagnosed with COVID-19 after birth, of which three (1.1 per cent) were from mothers who were COVID-19 vaccinated and one infant (1.3 per cent) was from a mother who was not vaccinated. Senior Author of the study, Dr Yeo Kee Thai, Senior Consultant, Department of Neonatology, KKH ...

Despite the importance of biodiversity and the urgency to conserve it, assessing what aspect of biodiversity requires the highest priority has proven complex, especially when conservation resources are limited. A new study published in Current Biology sheds light on this question.  Prof. CHEN Zhiduan's team from the Institute of Botany of the Chinese Academy of Sciences (IBCAS) and international collaborators have identified the spatial heterogeneity of biodiversity hotspots and endemism centers. With ...

Kyoto, Japan -- Cells possess an innate immune system that defends against invasive pathogens such as bacteria and viruses. Previous studies have mapped out the cytoplasmic cGAS-STING pathway in the cytoplasm, known for responding to foreign nucleic acids, such as double-stranded DNA. Micronuclei -- or MN, abnormal intracellular structures containing the cell's DNA -- have also been suspected of triggering the pathway. However, no conclusive evidence exists of pathway activation by MN-induced cyclic GMP-AMP synthase, or cGAS. Now, Kyoto University and the AIRC Institute of Molecular Oncology, or IFOM, have ...

Ultraviolet rays find diverse applications in medical and healthcare, serving purposes such as disinfection, sterilization, and therapy. They are also used in the semiconductor industry for creating microcircuits and patterns. A metalens fabrication process, developed by a team of researchers at Pohang University of Science and Technology (POSTECH), enables control over the optical properties of these UV rays. This innovation has garnered significant attention across industries, sparking interest in potential advancements.   A collaborative research team, comprising Professor Junsuk Rho from the Department of Mechanical Engineering and the Department of Chemical Engineering ...

A new study highlights a potential therapeutic target for immune-related disorders, such as multiple sclerosis and asthma. A new study has shed light on the importance of the protein STAP-1 in activating certain immune cells. Understanding the role of STAP-1 in these cells could give researchers a better glimpse into immune-related disorders and ways to treat them. The researchers found that STAP-1 plays an important role in the activation of T cells, which are white blood cells that play a critical role in defending the body against infections and maintaining overall health. T cells are adept at recognizing foreign molecules that ...

**Embargo:  23:30 UK, 7:30 p.m. ET March 11, 2024** ***Please note the unusual embargo time for the United States due to daylight savings time*** Global Burden of Disease COVID-19 had greater impact on life expectancy than previously known, but child mortality rates continued to decline during the pandemic A new study published in The Lancet reveals never-before-seen details about staggeringly high mortality from the COVID-19 pandemic within and across countries. Places such as Mexico City, Peru, and Bolivia had some of the largest drops in life expectancy from 2019 to 2021. The research, which presents updated ...

Congratulations to Dr. Jordon Gilmore for receiving the prestigious NSF CAREER Award! The project is titled: "A Multi-phase Biosensing Approach towards Point-of-Care Evaluation of Pseudomonas aeruginosa Virulence in Infected Chronic Wounds". The project is in perfect alignment with the ADAPT in SC NSF Award. Dr. Gilmore is a co-leader of the the Explainable AI-Enabled Biomedical Devices for Diagnostics and Planning Applications, and the leader of the Broadening Participation and Diversity project areas of ADAPT in SC. In addition, he serves as a member of the ...

Neural networks have been powering breakthroughs in artificial intelligence, including the large language models that are now being used in a wide range of applications, from finance, to human resources to healthcare. But these networks remain a black box whose inner workings engineers and scientists struggle to understand. Now, a team led by data and computer scientists at the University of California San Diego has given neural networks the equivalent of an X-ray to uncover how they actually learn.  The researchers found that a formula used in statistical analysis provides a streamlined mathematical description of how neural networks, such as GPT-2, a precursor ...

Researchers at the Francis Crick Institute and the National Institute for Health and Care Research Biomedical Research Centre at UCLH have highlighted the importance of continued surveillance of emerging SARS-CoV-2 variants and vaccine performance as the virus continues to evolve. Published today as a research letter in The Lancet, their study compared the newer monovalent COVID vaccine, which specifically targets the XBB variant of Omicron (as recommended by the World Health Organisation), with older bivalent vaccines containing a mix of an Omicron variant and the original strain of COVID-19, which ...

While Instagram might have a reputation for superficiality — a realm of exquisitely filtered images — it is now eclipsing other social media as a news source. The platform is increasingly filled with information, some of it pernicious and distributed via influencers. Researchers at the University of Washington studied three prominent Instagram influencers spreading anti-vaccine misinformation as a route to profit. Each account occupies what lead author Rachel E. Moran, a UW senior research scientist at the Center for an Informed Public (CIP) and staff researcher in the ...