Contact Information:

Media Contact

Vanessa Wasta

Twitter: HopkinsMedicine

Kredyty mieszkaniowe Kredyty mieszkaniowe

Sprawdź aktualny ranking najlepszych kredytów mieszkaniowych w Polsce - atrakcyjne kredytowanie nieruchomości. - Press Release Distribution
RSS - Press News Release
Add Press Release

Study: Some with low-risk prostate cancer not likely to succumb to the disease

Data on long-term outcomes of 1,298 men point to value of surveillance versus surgery or radiation for some, say Johns Hopkins researchers

( Men with relatively unaggressive prostate tumors and whose disease is carefully monitored by urologists are unlikely to develop metastatic prostate cancer or die of their cancers, according to results of a study by researchers at the Brady Urological Institute at Johns Hopkins, who analyzed survival statistics up to 15 years.

Specifically, the researchers report, just two of 1,298 men enrolled over the past 20 years in a so-called active surveillance program at Johns Hopkins died of prostate cancer, and three developed metastatic disease.

"Our study should reassure men that carefully selected patients enrolled in active surveillance programs for their low-risk prostate cancers are not likely to be harmed by their disease," says H. Ballentine Carter, M.D., the Bernard L. Schwartz Distinguished Professor of Urologic Oncology and director of adult urology.

Carter acknowledges that outcomes in the current study may be due to doctors' careful selection of patients for active surveillance. "With longer follow-up, the data may change, but they're unlikely to change dramatically, because men in this age group tend to die of other causes," he says.

Most of the men in the study were also Caucasian, and Carter cautions that these outcomes may not apply to African-American men, who tend to have more aggressive cancers.

For the study, described online Aug. 31 in the Journal of Clinical Oncology, men with prostate tumors classified as low or very low risk for aggressiveness opted to enroll in an active surveillance program at The Johns Hopkins Hospital. Their risk level was determined, in part, by Gleason scores, in which pathologists evaluate the aggressiveness of the cancer from prostate biopsy tissue.

When the study began in 1995, Carter says, urologists performed annual biopsies on the men in the program until they reached age 75. Now, doctors no longer require annual biopsies among the lowest risk groups, but when they do perform a biopsy, they use MRI-guided technology and will often ask pathologists to check biopsy tissue levels of proteins made by the PTEN gene, a biomarker for prostate cancer aggressiveness.

Of the 1,298 men, 47 died of nonprostate cancer causes, mostly cardiovascular disease; nine of the 47 had received treatment for their prostate cancer. Two men died from prostate cancer, one after 16 years in the active surveillance program. In the second man's case, Johns Hopkins doctors recommended surveillance, but the patient sought monitoring at another hospital and died 15 months after his diagnosis.

Three men in the program were diagnosed with metastatic prostate cancer.

Overall, the researchers calculated that men in the program were 24 times more likely to die from a cause other than prostate cancer over a 15-year span.

After 10 and 15 years of follow-up, survival free of prostate cancer death was 99.9 percent, and survival without metastasis was 99.4 percent in the group.

Some 467 men in the group (36 percent) had prostate cancers that were reclassified to a more aggressive level within a median time of two years from enrollment in the active surveillance program. For men with very low-risk cancers, the cumulative risk of a grade reclassification to a level that would have generally precluded enrollment in the program over five, 10 and 15 years was 13 percent, 21 percent and 22 percent, respectively. For men with low-risk cancers, this risk increased to 19 percent, 28 percent and 31 percent. Over the same time frames, the cumulative risk of a grade reclassification to a level that would be considered potentially lethal in most cases but still curable was no more than 5.9 percent for both very low and low-risk prostate cancers, Carter says.

Also among the group, 109 men opted for surgical or radiation treatment despite the absence of significant change in their prostate cancer status. In those whose cancers were reclassified, 361 opted for treatment.

"The natural progression of prostate cancer occurs over a long period of time, some 20 years, and most men with low-risk prostate cancer will die of another cause," says Carter, a member of the Johns Hopkins Kimmel Cancer Center. "There is a careful balance, which is sometimes difficult to find, between doing no harm without treatment and overtreating men, but our data should help."

Carter estimates that 30 to 40 percent of U.S. men with eligible prostate cancers opt for active surveillance, compared with Scandinavian countries, where use of the option is as high as 80 percent. The reasons for less use in the U.S., he says, could stem from fear of losing the opportunity for a cure.

Carter says one of the benefits of active surveillance is reduction in the rates of complications and costs of prostate cancer treatments. In a recent report, 20 percent of men undergoing a prostate cancer treatment -- radiation or surgery -- were readmitted to the hospital within five years of treatment for a complication related to the original treatment.

"Our goal is to avoid treating men who don't need surgery or radiation. The ability to identify men with the most indolent cancers for whom surveillance is safe is likely to improve with better imaging techniques and biomarkers," says Carter.

Active surveillance is included in best practice guidelines for doctors developed by the National Comprehensive Cancer Network, a group of the nation's top cancer centers. Carter recommends that men see urology specialists to be monitored in an active surveillance program.


Funding for the study was provided by the Prostate Cancer Foundation and several philanthropists including the Joan and Art Connolly Family Fund, the Roger S. Firestone Foundation, Neil A. Green, M.D., Mr. George C. Tunis, Jr., the Blum-Kovler Foundation, the Bozzuto Family Charitable Fund, Mr. Jacob F. Bryan, IV, Mr. David I. Granger, Mr. Harvey G. Sherzer, Mr. Thomas M. Rollins, Mr. Wesley D. Stick, Jr., Mr. David Eppler, Rudi Kremer, Frank Vitez, and Phenix Technologies, among others.

In addition to Carter, the following researchers at Johns Hopkins contributed to the study: Jeffrey Tosoian, Mufaddal Mamawala, Jonathan Epstein, Patricia Landis, Sacha Wolf and Bruce Trock. Media Contacts: Vanessa Wasta, 410-614-2916, Amy Mone, 410-614-2915,


Team harnesses intense X-ray beam, observes unusual phenomenon for the first time

Lincoln, Neb., Aug. 31, 2015 -- Using an enormous X-ray laser -- one of only two such machines on Earth -- University of Nebraska-Lincoln physicist Matthias Fuchs and scientists from around the world beat formidable odds to observe one of the most fundamental interactions between X-rays and matter. The findings can aid future studies and may lead to novel new ways to diagnose matter in the future. Fuchs and his colleagues induced two X-ray photons to simultaneously collide with a single atom, which converts them into a single higher-energetic X-ray photon. It's a phenomenon ...

Columbia engineers develop new approach to modeling Amazon seasonal cycles

Columbia engineers develop new approach to modeling Amazon seasonal cycles
New York, NY--August 31, 2015--With the rise of CO2 in Earth's atmosphere, understanding the climate of tropical forests--the Amazon in particular--has become a critical research area. A recent NASA study showed that these regions are the biggest terrestrial carbon dioxide sinks on our planet, absorbing 1.4 billion metric tons of CO2 out of a total global terrestrial absorption of 2.5 billion. To simulate the tropical climate to learn more about its processes, climate scientists have typically been relying on general circulation models (GCMs) to simulate the tropical climate. ...

Sea temperature changes linked to mystery North Pacific ecosystem shifts

Longer, less frequent climate fluctuations may be contributing to abrupt and unexplained ecosystem shifts in the North Pacific, according to a study by the University of Exeter. Researchers have long been puzzled by two rapid and widespread changes in the abundance and distribution of North Pacific plankton and fish species that impacted the region's economically important salmon fisheries. In 1977, and again in 1989, the number of salmon in some areas plummeted, while it increased in other areas. These events have been dubbed regime shifts by researchers. Now, in ...

Short sleepers are 4 times more likely to catch a cold

A new study led by a UC San Francisco sleep researcher supports what parents have been saying for centuries: to avoid getting sick, be sure to get enough sleep. The team, which included researchers at Carnegie Mellon University and University of Pittsburgh Medical Center, found that people who sleep six hours a night or less are four times more likely to catch a cold when exposed to the virus, compared to those who spend more than seven hours a night in slumber land. This is the first study to use objective sleep measures to connect people's natural sleep habits and ...

New type of prion may cause, transmit neurodegeneration

Multiple System Atrophy (MSA), a neurodegenerative disorder with similarities to Parkinson's disease, is caused by a newly discovered type of prion, akin to the misfolded proteins involved in incurable progressive brain diseases such Creutzfeldt-Jakob Disease (CJD), according to two new research papers led by scientists at UC San Francisco. The findings suggest new approaches to developing treatments for MSA, which currently has no cure, but also raise a potential concern for clinicians or scientists who come in contact with MSA tissue. The new findings mark the first ...

New research confirms lack of sleep connected to getting sick

Scientists have long associated sufficient sleep with good health. Now they've confirmed it. In 2009, Carnegie Mellon University's Sheldon Cohen found for the first time that insufficient sleep is associated with a greater likelihood of catching a cold. To do this, Cohen, who has spent years exploring psychological factors contributing to illness, assessed participants self-reported sleep duration and efficiency levels and then exposed them to a common cold virus. Now, Cohen, the Robert E. Doherty University Professor of Psychology in the Dietrich College of Humanities ...

Plastic in 99 percent of seabirds by 2050

Plastic in 99 percent of seabirds by 2050
Researchers from CSIRO and Imperial College London have assessed how widespread the threat of plastic is for the world's seabirds, including albatrosses, shearwaters and penguins, and found the majority of seabird species have plastic in their gut. The study, led by Dr Chris Wilcox with co-authors Dr Denise Hardesty and Dr Erik van Sebille and published today in the journal PNAS, found that nearly 60 per cent of all seabird species have plastic in their gut. Based on analysis of published studies since the early 1960s, the researchers found that plastic is increasingly ...

Single mothers much more likely to live in poverty than single fathers, study finds

URBANA, Ill. - Single mothers earn significantly less than single fathers, and they're penalized for each additional child they have even though the income of single fathers remains the same or increases with each added child in their family. Men also make more for every additional year they invest in education, further widening the gender gap, reports a University of Illinois study. "Single mothers earn about two-thirds of what single fathers earn. Even when we control for such variables as occupation, numbers of hours worked, education, and social capital, the income ...

Study reveals human body has gone through four stages of evolution

BINGHAMTON, NY - Research into 430,000-year-old fossils collected in northern Spain found that the evolution of the human body's size and shape has gone through four main stages, according to a paper published this week. A large international research team including Binghamton University anthropologist Rolf Quam studied the body size and shape in the human fossil collection from the site of the Sima de los Huesos in the Sierra de Atapuerca in northern Spain. Dated to around 430,000 years ago, this site preserves the largest collection of human fossils found to date anywhere ...

Older people getting smarter, but not fitter

Older populations are scoring better on cognitive tests than people of the same age did in the past --a trend that could be linked to higher education rates and increased use of technology in our daily lives, say IIASA population researchers. People over age 50 are scoring increasingly better on tests of cognitive function, according to a new study published in the journal PLOS ONE. At the same time, however, the study showed that average physical health of the older population has declined. The study relied on representative survey data from Germany which measured cognitive ...


How your brain decides blame and punishment -- and how it can be changed

Uniquely human brain region enables punishment decisions

Pinpointing punishment

Chapman University publishes research on attractiveness and mating

E-cigarettes: Special issue from Nicotine & Tobacco Research

Placental problems in early pregnancy associated with 5-fold increased risk of OB & fetal disorders

UT study: Invasive brood parasites a threat to native bird species

Criminals acquire guns through social connections

Restoring ocean health

Report: Cancer remains leading cause of death in US Hispanics

Twin study suggests genetic factors contribute to insomnia in adults

To be fragrant or not: Why do some male hairstreak butterflies lack scent organs?

International team discovers natural defense against HIV

Bolivian biodiversity observatory takes its first steps

Choice of college major influences lifetime earnings more than simply getting a degree

Dominant strain of drug-resistant MRSA decreases in hospitals, but persists in community

Synthetic biology needs robust safety mechanisms before real world application

US defense agencies increase investment in federal synthetic biology research

Robots help to map England's only deep-water Marine Conservation Zone

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma

How much water do US fracking operations really use?

New approach to mammograms could improve reliability

The influence of citizen science grows despite some resistance

Unlocking secrets of how fossils form

What happens on the molecular level when smog gets into the lungs?

Using ultrasound to clean medical instruments

Platinum and iron oxide working together get the job done

Tiny silica particles could be used to repair damaged teeth, research shows

A quantum lab for everyone

No way? Charity's logo may influence perception of food in package

[] Study: Some with low-risk prostate cancer not likely to succumb to the disease
Data on long-term outcomes of 1,298 men point to value of surveillance versus surgery or radiation for some, say Johns Hopkins researchers is a service of DragonFly Company. All Rights Reserved.
Issuers of news releases are solely responsible for the accuracy of their content.