(Press-News.org) Enhanced luminal breast tumor response to antiestrogen therapy
Breast cancer can be divided into 4 major subtypes using molecular and genetic information from the tumors. Each subtype is associated with different prognosis and should be taken into consideration when making treatment decisions. In this issue of the Journal of Clinical Investigation, Rebecca Cook and colleagues at Vanderbilt University, found that expression of an oncogene, ERBB3, was enhanced in luminal breast cancers compared to other breast cancer subtypes. Addition of the ERBB3 protein to cultured luminal breast cancer cells increased the growth of the cells; however, depletion of this protein with an antibody promoted cancer cell death, and decreased tumor growth in vitro. The authors also demonstrated that ERBB3 was upregulated in luminal tumor samples and in cancer cell cultures that were treated with the cancer drug fulvestrant. Furthermore, the authors found that fulvestrant treatment in combination with anti-ERBB3 decreased both tumor cell survival and growth. These data suggests that ERBB3 could be a target for treatment of fulvestrant resistant breast cancers.
TITLE: ErbB3 downregulation enhances luminal breast tumor response to antiestrogens
AUTHOR CONTACT: Rebecca Cook
Vanderbilt University, Nashville, TN, USA
Phone: (615) 936-3813; E-mail: rebecca.cook@vanderbilt.edu
View this article at: http://www.jci.org/articles/view/66764?key=3c6382af86dfc9b8d2ca
Peritoneal dialysis as an intervention for stroke patients
Ischemic stroke is characterized by an interruption of the blood supply to the brain, which can lead to brain damage and even death. Excess amounts of the excitatory neurotransmitter glutamate are released during stroke events and further exacerbate brain cell death. Currently, there are no effective strategies for combatting the effects ischemic stroke. In this issue of the Journal of Clinical Investigation, José Sánchez-Prieto and colleagues at the Universidad Complutense demonstrate that peritoneal dialysis is an effective treatment for reducing glutamate levels in the blood following a stroke event. In a rat model of ischemic stroke, peritoneal dialysis reduced tissue damage in the brain. Furthermore, the authors found that peritoneal dialysis was able to reduce blood glutamate levels in humans undergoing dialysis for chronic kidney disease, Together, these data suggest that peritoneal dialysis immediately following ischemic stroke may help preserve brain tissue and function.
TITLE: Amelioration of ischemic brain damage by peritoneal dialysis
AUTHOR CONTACT: Jose Sanchez-Prieto
Universidad Complutense, Madrid, , ESP
Phone: 34 91 3943891; Fax: 34 91 3943909; E-mail: jsprieto@vet.ucm.es
View this article at: http://www.jci.org/articles/view/67284?key=13390aa9d60cae59e3d4
ALSO IN THIS ISSUE
TITLE: Epithelial stem cell mutations that promote squamous cell carcinoma metastasis
AUTHOR CONTACT: Xiao-Jing Wang
University of Colorado Denver, Aurora, CO, USA
Phone: 303-724-3001; E-mail: xj.wang@ucdenver.edu
View this article at: http://www.jci.org/articles/view/65856?key=77e85509708c7706458c
TITLE: Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling
AUTHOR CONTACT: Thomas Wang
Vanderbilt University, Nashville, TN, USA
Phone: 615-936-3099; Fax: 615-936-2029; E-mail: tjwang@partners.org
View this article at: http://www.jci.org/articles/view/67119?key=7266b22eb1e1f33f2002
TITLE: Kruppel-like factor 15 is critical for vascular inflammation
AUTHOR CONTACT: Mukesh Jain
Case Western Reserve University, Cleveland, OH, USA
Phone: 216-368-3607; E-mail: mukesh.jain2@case.edu
View this article at: http://www.jci.org/articles/view/68552?key=0a26637d5fe8bbbf33fd
TITLE: PP2A-Activating Drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
AUTHOR CONTACT: Danilo Perrotti
The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
Phone: 614-292-3567; Fax: 614-688-4181; E-mail: danilo.perrotti@osumc.edu
View this article at: http://www.jci.org/articles/view/68951?key=e45d4ca598337cfac760
TITLE: Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
AUTHOR CONTACT: Chad Dickey
University of South Florida, Tampa, FL, USA
Phone: 813-396-0639; E-mail: cdickey@health.usf.edu
View this article at: http://www.jci.org/articles/view/69003?key=79f8a0e2c154e42c41dc
TITLE: Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses
AUTHOR CONTACT: James E. Crowe, Jr.
Vanderbilt University Medical Center, Nashville, TN, USA
Phone: 615-343-8064; Fax: 615-343-4456; E-mail: james.crowe@vanderbilt.edu
View this article at: http://www.jci.org/articles/view/69377?key=37d2cb3f4dcb2f149c0b
TITLE: Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression
AUTHOR CONTACT: Christian Kurts
Institute of Molecular Medicine and Experimental Immunology, Bonn, UNK, DEU
Phone: 49-228-287-1031; Fax: 49-228-287-1052; E-mail: ckurts@web.de
View this article at: http://www.jci.org/articles/view/70143?key=f98fe358079460b96d54
INFORMATION:
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Breast cancer can be divided into 4 major subtypes using molecular and genetic information from the tumors. Each subtype is associated with different prognosis and should be taken into consideration when making treatment decisions.
In this issue of the Journal of Clinical Investigation, Rebecca Cook and colleagues at Vanderbilt University, found that expression of an oncogene, ERBB3, was enhanced in luminal breast cancers compared to other breast cancer subtypes. Addition of the ERBB3 protein to cultured luminal breast cancer cells increased the growth of the cells; ...
Ischemic stroke is characterized by an interruption of the blood supply to the brain, which can lead to brain damage and even death. Excess amounts of the excitatory neurotransmitter glutamate are released during stroke events and further exacerbate brain cell death. Currently, there are no effective strategies for combatting the effects ischemic stroke.
In this issue of the Journal of Clinical Investigation , José Sánchez-Prieto and colleagues at the Universidad Complutense demonstrate that peritoneal dialysis is an effective treatment for reducing glutamate levels ...
Research has shown that giving obese rodents a recently identified circulating protein called fibroblast growth factor 21 (FGF21) helps improve their metabolism. Now investigators reporting in the Cell Press journal Cell Metabolism reveal that a variant of FGF21 has similar effects in obese people with type 2 diabetes.
"Our findings suggest that FGF21 has the ability to favorably affect body weight and to partially normalize abnormal lipid levels in patients with diabetes. These are substantial issues and unmet medical needs for patients with obesity and type 2 diabetes," ...
An antihistamine discovered in the 1950s to treat itching may also prevent seizures in an intractable form of childhood epilepsy, according to researchers at UC San Francisco who tested it in zebrafish bred to mimic the disease.
The researchers said their unexpected discovery offers a glimmer of hope for families of children with Dravet Syndrome, a rare genetic disorder that manifests in early childhood with disabling, lifelong consequences. These include dozens, if not hundreds, of daily seizures, as well as profound cognitive and social deficits.
“It is very ...
RIVERSIDE, Calif. (http://www.ucr.edu) — A team of University of California, Riverside researchers have developed a novel transparent skull implant that literally provides a "window to the brain", which they hope will eventually open new treatment options for patients with life-threatening neurological disorders, such as brain cancer and traumatic brain injury.
The team's implant is made of the same ceramic material currently used in hip implants and dental crowns, yttria-stabilized zirconia (YSZ). However, the key difference is that their material has been processed ...
Among scientists, the role of proteins called sirtuins in enhancing longevity has been hotly debated, driven by contradictory results from many different scientists. But new research at Washington University School of Medicine in St. Louis may settle the dispute.
Reporting Sept. 3 in Cell Metabolism, Shin-ichiro Imai, MD, PhD, and his colleagues have identified the mechanism by which a specific sirtuin protein called Sirt1 operates in the brain to bring about a significant delay in aging and an increase in longevity. Both have been associated with a low-calorie diet.
The ...
Among patients with prehypertension and coronary artery disease, use of the renin (an enzyme secreted by the kidneys) inhibitor aliskiren, compared with placebo, did not result in improvement or slowing in the progression of coronary atherosclerosis, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the European Society of Cardiology Congress 2013.
"Guidelines recommend blood pressure reduction in patients with hypertension with a treatment goal of 140 mm Hg for systolic and 90 mm Hg diastolic blood ...
ANN ARBOR—When the tiny roundworm C. elegans reaches middle age—at about 2 weeks old—it can't quite move like it did in the bloom of youth. But rather than imposing an exercise regimen to rebuild the worm's body-wall muscles, researchers can bring the wriggle back by stimulating the animal's neurons. And, they say, pharmaceuticals might have a similar effect in mammals.
Scientists at the University of Michigan's Life Sciences Institute and Medical School have found that the loss of motor ability associated with aging begins in neurons and spreads to muscles, and that ...
According to new research on epilepsy, zebrafish have certainly earned their stripes. Results of a study in Nature Communications suggest that zebrafish carrying a specific mutation may help researchers discover treatments for Dravet syndrome (DS), a severe form of pediatric epilepsy that results in drug-resistant seizures and developmental delays.
Scott C. Baraban, Ph.D., and his colleagues at the University of California, San Francisco (UCSF), carefully assessed whether the mutated zebrafish could serve as a model for DS, and then developed a new screening method ...
A long-term study of children with a complex heart condition called hypertrophic cardiomyopathy (HCM) found that the risk of death or need for immediate listing for heart transplantation was greatest for those who developed this disease as infants with congestive heart failure and for children who also had selective inborn errors of metabolism, a group of rare genetic disorders in which one or more of the body's key metabolic processes are disrupted.
The findings will be published online Tuesday in The Lancet to coincide with a presentation at the European Society of ...
