Hybrid heart valve is strong, durable in early tests

Abstract 15923 (Hall F, Core 6, Poster Board: 6078)

2013-11-18

(Press-News.org) Contact information: Karen Astle
karen.astle@heart.org
214-706-1392
American Heart Association
Hybrid heart valve is strong, durable in early tests Abstract 15923 (Hall F, Core 6, Poster Board: 6078) A hybrid heart valve created from thin and highly elastic mesh embedded within layers of human cells was strong and durable in a study presented at the American Heart Association's Scientific Sessions 2013. Researchers created a three-dimensional cell culture by coating a scaffold of nickel-titanium alloy (Nitinol), used for devices that require flexibility and motion, with layers of smooth muscle, connective tissue and lining cells. The valves performed well in a heart simulator, opening and closing under various pressures and remaining stable and strong throughout the tests. A durable, regenerating hybrid heart valve would be an important advance because previous attempts to create tissue-engineered heart valves from patients' cells have been unsatisfactory. All the prior methods entail significant limitations due to structural vulnerability, short-term functionality and mechanical properties of the tissue-engineered valves.

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