(Press-News.org) Contact information: Vicki Cohn
vcohn@liebertpub.com
914-740-2100 x2156
Mary Ann Liebert, Inc./Genetic Engineering News
Critical factor (BRG1) identified for maintaining stem cell pluripotency
New Rochelle, NY, February 6, 2014—The ability to reprogram adult cells so they return to an undifferentiated, pluripotent state—much like an embryonic stem cell—is enabling the development of promising new cell therapies. Accelerating progress in this field will depend on identifying factors that promote pluripotency, such as the Brg1 protein described in a new study published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.
In "BRG1 Is Required to Maintain Pluripotency of Murine Embryonic Stem Cells," Nishant Singhal and coauthors, Max Planck Institute for Molecular Biomedicine, Münster, and University of Münster, Germany, demonstrate the critical role the Brg1 protein plays in regulating genes that are part of a network involved in maintaining the pluripotency of embryonic stem cells. This same network is the target for methods developed to reprogram adult somatic cells.
"This work further clarifies the role of the Brg1 containing BAF complex in regulating pluripotency and has important implications for all cellular reprogramming technologies," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland.
INFORMATION:
About the Journal
BioResearch Open Access is a bimonthly peer-reviewed open access journal led by Editor-in-Chief Robert Lanza, MD, Chief Scientific Officer, Advanced Cell Technology, Inc. and Editor Jane Taylor, PhD. The Journal provides a new rapid-publication forum for a broad range of scientific topics including molecular and cellular biology, tissue engineering and biomaterials, bioengineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, biochemistry, virology, microbiology, and neuroscience. All articles are published within 4 weeks of acceptance and are fully open access and posted on PubMedCentral. All journal content is available on the BioResearch Open Access website.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in promising areas of science and biomedical research, including, DNA and Cell Biology, Tissue Engineering, Stem Cells and Development, Human Gene Therapy, HGT Methods, and HGT Clinical Development, and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.
Mary Ann Liebert, Inc.
140 Huguenot St.New Rochelle, NY 10801-5215
http://www.liebertpub.com
Phone: (914) 740-2100
(800) M-LIEBERT Fax: (914) 740-2101
Critical factor (BRG1) identified for maintaining stem cell pluripotency
2014-02-06
ELSE PRESS RELEASES FROM THIS DATE:
What's love got to do with it?
2014-02-06
Fairfax, Va. – Feb. 6, 2014 – A first-of-its-kind study by researchers at George Mason University's Department of Global and Community Health and Indiana University's Center for ...
Scientists use 'voting' and 'penalties' to overcome errors in quantum optimization
2014-02-06
Seeking a solution to decoherence—the ...
Ballistic transport in graphene suggests new type of electronic device
2014-02-06
Using electrons more like photons could provide the foundation for a new type of electronic device that would capitalize on the ability of graphene to carry electrons with almost no resistance ...
Amputee feels in real-time with bionic hand
2014-02-06
PUBLIC RELEASE DATE: 5-Feb-2014
[
| E-mail
]
var addthis_pub="eurekalert"; var addthis_options = "favorites, delicious, digg, facebook, twitter, google, newsvine, reddit, slashdot, stumbleupon, buzz, more"
Share
Contact: Hillary Sanctuary
hillary.sanctuary@epfl.ch
41-216-937-022
Ecole Polytechnique Fédérale de Lausanne
Amputee feels in real-time with bionic hand
Dennis Aabo Sorensen is the first amputee in the world to feel sensory rich information -- in real-time -- with a prosthetic hand wired to nerves in his upper arm; Sorensen could grasp objects ...
Inducing climate-smart global supply networks: Nature Commentary
2014-02-06
In a Nature Commentary he proposes a community effort to collect economic data on the new website zeean.net. The aim is to better understand economic flows and to thereby ...
New approach prevents thrombosis without increasing the risk of bleeding
2014-02-06
In collaboration with an international team, researchers at Karolinska Institutet in Sweden have developed an antibody, 3F7, which blocks a protein that is active in the coagulation system factor ...
Some receive unnecessary prioritization for liver transplantation, says Penn Medicine study
2014-02-06
(PHILADELPHIA) – Patients waiting for liver transplants ...
New analysis of endometriosis could help diagnoses, treatments
2014-02-06
CAMBRIDGE, MA -- Endometriosis, the invasive displacement of uterine tissue into surrounding organs, affects at least 10 percent of women. The disease, which is often misdiagnosed, can cause ...
Female mice prefer unfamiliar male songs
2014-02-06
Female mice prefer songs of mice that are different from their parents when selecting a mate, according to a study published February 5, 2014 in PLOS ONE by Akari Asaba from the Azabu University, ...
Mass extinction may not cause all organisms to 'shrink'
2014-02-06
The sizes of organisms following mass extinction events may vary more than previously thought, which may be inconsistent with the predictions of the so-called ...