(Press-News.org) Visualizing calcium dynamics in the kidney
In this issue of the Journal of Clinical Investigation, Janos Peti-Peterdi and colleagues at the University of Southern California used multiphoton microscopy (MPM) to directly visualize podocyte calcium dynamics within the intact kidneys of live mice. A robust calcium wave was generated in response to glomerular injury and this signal spread throughout cells. Mice lacking the P2Y2 purinergic receptor or treated with inhibitors of calcium signaling prevented propagation of a calcium wave. Furthermore, increased calcium signaling correlated with loss of glomerular filter integrity. Together this results suggest that calcium signaling mediates pathogenic responses to injury in the kidney.
TITLE:
Intravital imaging of podocyte calcium in glomerular injury and disease
AUTHOR CONTACT:
Janos Peti-Peterdi
University of Southern California, Los Angeles, CA, USA
Phone: 323-442-4337; E-mail: petipete@usc.edu
View this article at: http://www.jci.org/articles/view/71702
Characterization of an asplenic patient with disorder of sexual development
Mutations with in the gene encoding the transcription factor steroidogenic factor 1 (SF-1) are associated with disorders of sexual development (DSD), including sex reversal, spermatogenic failure, ovarian insufficiency, and adrenocortical deficiency. In this issue of the Journal of Clinical Investigation, David Zangen and colleagues at Hadassah Hebrew University Medical Centre identified a recessive mutation within SF1 that resulted in both severe 46,XY-DSD and asplenia in a pediatric patient. Interestingly, this particular SFI mutation decreased transactivation of TLX1, a transcription factor essential for murine spleen development. Additionally, the SF1 mutation decreased expression of steroidogenic genes, without affecting synergistic SF-1 and sex-determining region Y (SRY) coactivation of the testis development gene SOX9. This study indicates that SF-1 is required for both steroidogenesis and spleen development in humans.
TITLE:
Testicular differentiation factor SF-1 is required for human spleen development
AUTHOR CONTACT:
David Zangen
Hadassah Hebrew University Medical Centre, Jerusalem, ISR
Phone: 972.2.5844430; E-mail: zangend@hadassah.org.il
View this article at: http://www.jci.org/articles/view/73186
ENDOCRINOLOGY
TITLE:
Vascular rarefaction mediates whitening of brown fat in obesity
AUTHOR CONTACT:
Kenneth Walsh
Boston University School of Medicine, Boston, MA, USA
Phone: 617-414-2392; Fax: 617-414-2391; E-mail: kxwalsh@bu.edu
View this article at: http://www.jci.org/articles/view/71643
TITLE:
Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes
AUTHOR CONTACT:
Antonio Zorzano
Institute for Research in Biomedicine (IRB Barcelona), Barcelona, ESP
Phone: 34-93-403-7197;; E-mail: antonio.zorzano@irbbarcelona.org
View this article at: http://www.jci.org/articles/view/72327
IMMUNOLOGY
TITLE:
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
AUTHOR CONTACT:
Nathan Karin
Department of Immunology, Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, ISR
Phone: 972.4.8295232; E-mail: nkarin10@gmail.com
View this article at: http://www.jci.org/articles/view/71951
ONCOLOGY
TITLE:
Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC
AUTHOR CONTACT:
Jin Chen
Vanderbilt University School of Medicine, Nashville, TN, USA
Phone: 615-343-3819; Fax: 615-343-8648; E-mail: jin.chen@vanderbilt.edu
View this article at: http://www.jci.org/articles/view/72522
HEPATOLOGY
TITLE:
Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway
AUTHOR CONTACT:
Anthony N. Hollenberg
Beth Israel Medical Center, Harvard Medical School, Boston, MA, USA
Phone: 617.735.3268; E-mail: thollenb@bidmc.harvard.edu
View this article at: http://www.jci.org/articles/view/73419
INFORMATION: END
JCI online ahead of print table of contents for April 8, 2014
2014-04-09
ELSE PRESS RELEASES FROM THIS DATE:
Physical activity is beneficial for late-life cognition
2014-04-09
Physical activity in midlife seems to protect from dementia in old age, according to a study carried out at the University of Eastern Finland. Those who engaged in physical activity at least twice a week had a lower risk of dementia than those who were less active. The protective effects were particularly strong among overweight individuals. In addition, the results showed that becoming more physically active after midlife may also contribute to lowering dementia risk.
Several modifiable risk factors for dementia have been suggested, but further refinement of this information ...
New research reveals the reality of adoption breakdowns
2014-04-09
The most comprehensive study ever to be carried out into adoption in England has confirmed that the rate of breakdown is lower than anticipated, but it also reveals a stark picture of the problems faced by families.
Researchers from the University of Bristol analysed national data on 37,335 adoptions over a 12 year period to show that 3.2 per cent of children – around three in 100 - move out of their adoptive home prematurely, known as a 'disruption'.
Adoptions were more likely to breakdown if a child was placed once they were over the age of four. Most adoptions breakdown ...
Study tests theory that life originated at deep sea vents
2014-04-09
One of the greatest mysteries facing humans is how life originated on Earth. Scientists have determined approximately when life began (roughly 3.8 billion years ago), but there is still intense debate about exactly how life began. One possibility - that simple metabolic reactions emerged near ancient seafloor hot springs, enabling the leap from a non-living to a living world – has grown in popularity in the last two decades.
Recent research by geochemists Eoghan Reeves, Jeff Seewald, and Jill McDermott at Woods Hole Oceanographic Institution (WHOI) is the first to test ...
Refrigerant in cars: Refreshingly cool, potentially toxic
2014-04-09
The refrigerant R1234yf is being considered for use in air conditioning systems in cars. Chemists at Ludwig-Maximilians-Universitaet (LMU) in Munich now show that, in the event of a fire, it releases the highly poisonous carbonyl fluoride, and urge that its safety be reassessed.
According to EU guidelines, the new compound R1234yf should in future be used as the refrigerant in air-conditioning systems for automobiles. But the compound is inflammable, and LMU chemists have now shown that combustion of the cooling agent leads to the formation of the highly toxic carbonyl ...
Chance meeting creates celestial diamond ring
2014-04-09
Most stars with masses similar to that of our Sun will end their lives as white dwarfs — small, very dense, and hot bodies that slowly cool down over billions of years. On the way to this final phase of their lives the stars throw their atmospheres out into the space and create planetary nebulae, colourful glowing clouds of gas surrounding the small, bright stellar relics.
This image, captured by ESO's Very Large Telescope (VLT), shows the remarkably round planetary nebula Abell 33, located some 1500 light-years from Earth. Being perfectly round is uncommon for these ...
EASL publishes online recommendations on the management of hepatitis C
2014-04-09
London, UK, Wednesday 9 April 2014: The European Association for the Study of the Liver (EASL) will this week be announcing new on-line recommendations on the management of hepatitis C (HCV) at the International Liver Congress™ (ILC). These EASL recommendations reflect the approval of three new direct-acting antivirals (DAAs) during 2014 by the European Medicines Agency.
It is estimated that approximately 185 million people are infected with HCV on a global scale, with approximately 150 million people living with chronic infection. In Europe, between 7.3 million and ...
Women and minorities more likely to receive stroke misdiagnosis
2014-04-09
Women and minorities more likely to receive stroke misdiagnosis
Article provided by Davis & Davis
Visit us at http://www.dfwmedmal.com
The misdiagnosis of an illness or disease can have tragic consequences. A patient complaining of headaches and dizziness may be sent home only to suffer a debilitating stroke. Poor hospital care, which includes misdiagnosis or delayed diagnosis, could contribute to 180,000 deaths each year, according to the U.S. Department of Health and Human Services.
Recently, a John Hopkins team of researchers concluded that doctors often ...
Take time to learn to co-parent effectively with your former spouse
2014-04-09
Take time to learn to co-parent effectively with your former spouse
Article provided by Carlson, Carlson & Dunkelman, L.L.C.
Visit us at http://www.ccdlawyers.com
Have you and your significant other decided it is time to end your marriage? Are you feeling somewhat overwhelmed by what this decision entails and how it will affect your children? In such situations, when a couple decides to divorce, it can be difficult to adjust to the new parenting demands.
Consequently, when divorcing, it is wise to entrust the legal aspects of the split to a skilled attorney ...
Bad faith refusal to settle claims against insurers in Missouri
2014-04-09
Bad faith refusal to settle claims against insurers in Missouri
Article provided by Leritz, Plunkert & Bruning, PC
Visit us at http://www.leritzlaw.com
An insurance company operates in bad faith when it fails to pay a legitimate first party claim made by an insured person without a reasonable basis. Insurance companies can face liability beyond the limits of the insurance policies they issue if they operate in bad faith.
Vexatious refusal to pay
Missouri common law does not recognize a first party claim for bad faith, as many other states do. However, when ...
Responex is the New Trade Name of Genebis
2014-04-09
Genebis, a leading provider of marketing services and solutions for organizations, announced today the company will begin operating under a new trade name and will be known as Responex effective immediately. At the same time, the company unveiled a new identity and redesigned Web site, http://www.responex.com. The new site prominently features the company's focus on responsive website development, marketing campaign management, and marketing strategy development using a new express framework and new technologies. The company's ownership and staff have not changed.
President ...