PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study of 55 million people adds further evidence that patients admitted to hospital at weekends have higher mortality

2014-06-01
(Press-News.org) A systematic review and meta-analysis of hospital data worldwide, presented as this year's Euroanaesthesia meeting in Stockholm, adds further evidence that patients admitted to hospital at weekends have higher mortality than those admitted on weekdays. The study is by Dr Hiroshi Hoshijima, Tohoku University, Sendai, Japan, and colleagues.

The analysis included 72 studies from various world regions, covering 55,053,719 participants. The authors found that weekend admission was associated with increased morality of between 15% and 17% depending on the statistical technique used.

Subgroup analysis revealed that patients admitted during the weekend were at a higher risk of death than weekday admission in patients in almost all categories. "There are at least two potential explanations for our results. First, these differences reflect poorer quality of care in hospital at the weekend, and second, patients admitted on at weekend could be more severely ill than those admitted on at weekday. We believe that poorer care at the weekends is the much more likely explanation."

The only exception to this trend was for the patients who underwent surgery, with the authors saying the lack of association between postoperative mortality and weekdays being potentially due to the few numbers of studies (just 4 studies) specifically examining postoperative mortality.

Furthermore, the authors say that, in some patients who underwent selected high risk procedures, these patients could received a substantial proportion of their postoperative care in critical care units that are more likely to provide the same type of service at all times during both weekdays and weekends. This would therefore dilute any effect of increased weekend mortality in these post-surgery patients.

The authors conclude: "Our systematic review shows that weekend admission is associated with higher mortality compared with weekday admission."

INFORMATION: END


ELSE PRESS RELEASES FROM THIS DATE:

Risk of death highest following surgery in afternoons, at weekends, and in February

2014-06-01
New research presented at this year's Euroanaesthesia show that on weekends, in the afternoons and in February are the times when the risk of death following surgery is the highest. The research is by Dr Felix Kork and Professor Claudia Spies, Charité - University Medicine Berlin, Germany and colleagues. Hospital mortality is subject to day-night, weekly and seasonal variability. This has been shown for various populations, settings, and in different regions of the world. However, a cyclic influence on hospital mortality has not been shown in patients after surgery. ...

Poor coverage of specific gene sets in exome sequencing gives cause for concern

2014-06-01
With services based on exome sequencing becoming affordable to patients at a reasonable price, the question of the quality of the results provided has become increasingly important. The exome is the DNA sequence of genes that are translated into protein. These protein-coding regions contain most of the currently-known disease-causing genetic mutations. The American College of Medical Genetics and Genomics (ACMG) has recommended the reporting to patients of clinically actionable incidental genetic findings in the course of clinical exome testing. Specifically, mutations ...

Responses with crizotinib in MET-amplified lung cancer show new targetable form of disease

2014-05-31
A study presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2014 reports the results of a first-in-human, phase 1 dose escalation trial of crizotinib (XALKORI) in 14 patients with advanced, MET-amplified non-small cell lung cancer (NCT00585195). In 2011, the drug crizotinib earned accelerated approval by the US FDA to target the subset of advanced non-small cell lung cancers caused by rearrangements of the anaplastic lymphoma kinase (ALK) gene, and subsequently was granted regular approval in 2013. The drug also has shown dramatic responses in ...

Results in Phase I trial of OMP-54F28, a Wnt inhibitor targeting cancer stem cells

2014-05-31
At the 50th Annual Meeting of the American Society for Clinical Oncology (ASCO), University of Colorado Cancer Center researchers reported results of a Phase I trial of OMP-54F28 (FZD8-Fc), an investigational drug candidate discovered by OncoMed Pharmaceuticals targeting cancer stem cells (CSCs). The drug was generally well tolerated, and several of the 26 patients with advanced solid tumors experienced stable disease for greater than six months. Three trials are now open for OMP-54F28 (FZD8-Fc) in combinations with standard therapy for pancreatic, ovarian and liver cancers, ...

ASCO: One step closer to a breath test for lung cancer

2014-05-31
Results of a University of Colorado Cancer Center study presented at the 50th Annual Meeting of the American Society for Clinical Oncology (ASCO) show that a test of organic compounds in exhaled breath can not only distinguish patients with lung cancer from patients with chronic obstructive pulmonary disease (COPD), but can also define the stage of any cancer present. "This could totally revolutionize lung cancer screening and diagnosis. The perspective here is the development of a non-traumatic, easy, cheap approach to early detection and differentiation of lung cancer," ...

ALK, ROS1 and now NTRK1: Study shows prevalence of new genetic driver in lung cancer

2014-05-31
A University of Colorado Cancer Center study presented at the 50th Annual Meeting of the American Society for Clinical Oncology (ASCO) draws a line from mutation of the gene NTRK1, to its role as an oncogene in non-small cell lung cancer, to treatment that targets this mutation. The current study reports the prevalence of the NTRK1 mutation in an unselected population of 450 lung cancer samples, with >1% percent of patients testing positive. This and other work from Dr. Doebele's group forms the basis of a phase 1 clinical trial targeting NTRK1 mutations in advanced solid ...

Patients with metastatic colon cancer respond to new combination therapy

Patients with metastatic colon cancer respond to new combination therapy
2014-05-31
CHICAGO — In an aggressive disease known for poor response rates, researchers from The University of Texas MD Anderson Cancer Center found patients with advanced colorectal cancer responded well to a combination therapy of the drugs vermurafenib, cetuximab and irinotecan. The Phase I trial, presented Saturday, May 31 in a poster discussion at the American Society of Clinical Oncology's 2014 Annual Meeting in Chicago, examines a specific mutation in the BRAF gene, which is present in 5 to 10 percent of colorectal cancer patients. Previous research identified this mutation ...

Immune therapy for advanced bladder cancer yields promising results

2014-05-31
New Haven, Conn. — A multi-center phase I study using an investigational drug for advanced bladder cancer patients who did not respond to other treatments has shown promising results in patients with certain tumor types, researchers report. Yale Cancer Center played a key role in the study, the results of which will be presented Saturday, May 31 at the 2014 annual conference of the American Society of Clinical Oncology (ASCO) in Chicago. The trial included 68 people with previously treated advanced bladder cancer, including 30 patients identified as PD-L1 positive. PD-L1 ...

Phase 3 study strengthens support of ibrutinib as second-line therapy for CLL

2014-05-31
COLUMBUS, Ohio – In a head-to-head comparison of two Food and Drug Administration-approved drugs for the treatment of relapsed chronic lymphocytic leukemia (CLL), ibrutinib significantly outperformed ofatumumab as a second-line therapy, according to a multicenter interim study published in the OnLine First edition of the New England Journal of Medicine. Ibrutinib (Imbruvica) is the first drug designed to target Bruton's tyrosine kinase (BTK), a protein essential for CLL-cell survival and proliferation. CLL, the most common form of leukemia, causes a gradual increase ...

Mount Sinai researchers to present studies at American Society of Clinical Oncology Meeting

2014-05-31
(New York – UNDER EMBARGO May 31, 2014) Icahn School of Medicine at Mount Sinai researchers will present several landmark studies at the 2014 American Society of Clinical Oncology (ASCO) meeting May 30-June 3, 2014 in Chicago, including data on new treatment approaches for thyroid, head and neck, and recurrent ovarian cancers; and new biomarkers for bile duct cancers. Highlights of Mount Sinai research at ASCO: Phase II Trial on the Combination of Bevacizumab and Irinotecan in Recurrent Ovarian Cancer (Under Embargo Until SATURDAY, MAY 31, 8:00 – 11:45 AM) In a study ...

LAST 30 PRESS RELEASES:

Research on past hurricanes aims to reduce future risk

UT Health San Antonio, UTSA researchers receive prestigious 2025 Hill Prizes for medicine and technology

Panorama of our nearest galactic neighbor unveils hundreds of millions of stars

A chain reaction: HIV vaccines can lead to antibodies against antibodies

Bacteria in polymers form cables that grow into living gels

Rotavirus protein NSP4 manipulates gastrointestinal disease severity

‘Ding-dong:’ A study finds specific neurons with an immune doorbell

A major advance in biology combines DNA and RNA and could revolutionize cancer treatments

Neutrophil elastase as a predictor of delivery in pregnant women with preterm labor

NIH to lead implementation of National Plan to End Parkinson’s Act

Growth of private equity and hospital consolidation in primary care and price implications

Online advertising of compounded glucagon-like peptide-1 receptor agonists

Health care utilization and costs for older adults aging into Medicare after the affordable care act

Reading the genome and understanding evolution: Symbioses and gene transfer in leaf beetles

Brains of people with sickle cell disease appear older

Elena Belova and Yevgeny Raitses recognized for groundbreaking plasma physics research

SOX9 overexpression ameliorates metabolic dysfunction-associated steatohepatitis through activation of the AMPK pathway

Florescent probes illuminate cholesterol and Alzheimer’s research

Qigong significantly decreases chronic low back pain in US military veterans

New insights into pancreatic disease and diabetes

Effectiveness and safety of tenofovir amibufenamide in the treatment of chronic hepatitis B: A real-world, multicenter study

Higher costs limit attendance for life changing cardiac rehab

Over 500 patients receive diagnosis through genetic reanalysis

Brain changes in Huntington’s disease decades before diagnosis will guide future prevention trials

U of A astronomers capture unprecedented view of supermassive black hole in action

Astrophysicists reveal structure of 74 exocomet belts orbiting nearby stars in landmark survey

Textbooks need to be rewritten: RNA, not DNA, is the main cause of acute sunburn

Brits still associate working-class accents with criminal behavior – study warns of bias in the criminal justice system

What do you think ‘guilty’ sounds like? Scientists find accent stereotypes influence beliefs about who commits crimes

University of Calgary nursing study envisions child trauma treatment through a Marvel and DC lens

[Press-News.org] Study of 55 million people adds further evidence that patients admitted to hospital at weekends have higher mortality