German breast group study: Superior activity for nab-paclitaxel in early breast cancer
Study showing superior activity for nab-paclitaxel vs paclitxel in early breast cancer at San Antonio Breast Cancer Symposium, General Session 2, 4:45 PM CT, Wed, Dec 10th
2014-12-11
(Press-News.org) SAN ANTONIO, TX, USA and Neu-Isenburg/Frankfurt, Germany -- December 10, 2014 -- The German Breast Group (GBG) said nab-paclitaxel (ABRAXANE®) demonstrated significant benefit for patients with early high risk breast cancer when compared to conventional solvent-based paclitaxel. The findings are from the GeparSepto clinical trial sponsored by GBG and conducted together with the German AGO-B study group involving over 1200 patients, which is the largest randomized Phase III study ever completed with nab-paclitaxel and the first one completed in high risk early breast cancer. The results were presented by the coordinating investigator Michael Untch, M.D., Berlin in General Session 2 on December 10th, at the 2014 San Antonio Breast Cancer Symposium.
The study found a statistically significant and clinically meaningful 9% absolute improvement from 29% to 38% (p= END
ELSE PRESS RELEASES FROM THIS DATE:
Scientists create food ingredient that will make you feel fuller
2014-12-11
Scientists have developed an ingredient that can be added to foods to make them more filling.
In its first tests in humans, researchers at Imperial College London and the University of Glasgow found that the ingredient is effective at preventing weight gain in overweight volunteers.
The ingredient contains propionate, which stimulates the gut to release hormones that act on the brain to reduce hunger. Propionate is produced naturally when dietary fibre is fermented by microbes in the gut, but the new ingredient, called inulin-propionate ester (IPE), provides much larger ...
Racial and ethnic disparities narrow for acute care
2014-12-11
PROVIDENCE, R.I. [Brown University] -- A study of more than 12 million acute care hospitalizations over a five-year span found that as quality improved on each of 17 measures so did racial and ethnic equity. Nine major disparities evident in 2005 had mostly or totally disappeared by the end of 2010.
The study, led by Dr. Amal Trivedi of Brown University and published in the New England Journal of Medicine, found that care for blacks and Hispanics became better and more equitable when comparing hospitals principally serving whites to hospitals principally serving minorities, ...
How to achieve health equity
2014-12-11
Despite recent significant gains in health care access throughout the nation, people of color continue to grapple with a disproportionate burden of chronic disease. Two studies in the current issue of the New England Journal of Medicine (NEJM) indicate that differences in how care is delivered to patients in various racial or ethnic groups have narrowed nationally, but health outcomes remain worse for blacks than for whites.
In his editorial "How to Achieve Health Equity," also published in the just released NEJM, Marshall Chin, MD, MPH, the Richard Parrillo Family Professor ...
Novel fMRI technique identifies HIV-associated cognitive decline before symptoms occur
2014-12-11
WASHINGTON -- A five-minute functional MRI (fMRI) test can pick up neuronal dysfunction in HIV-positive individuals who don't yet exhibit cognitive decline, say neuroscientists and clinicians at Georgetown University Medical Center.
Their study in Neuroimaging: Clinical provides proof-of-concept that imaging can help track neural functioning in this population, known to be affected by the virus and potentially by the treatments meant to keep HIV at bay.
The issue of neural dysfunction in the HIV-positive population is significant, says Georgetown neuroscientist Xiong ...
Is care best in West? Racial gaps in Medicare Advantage persist across US, except in West
2014-12-11
ANN ARBOR, Mich. -- Despite years of effort to help American seniors with high blood pressure, heart disease, or diabetes get their blood pressure, cholesterol and blood sugar under control, new research shows wide gaps between older people of different ethnic backgrounds in all three of these key health measures.
Black seniors in Medicare Advantage health plans are still much less likely than their white peers to have each of the three measures in check, according to a new study published in the December 11 issue of the New England Journal of Medicine.
If not well ...
Progesterone offers no significant benefit in traumatic brain injury clinical trial
2014-12-11
Treatment of acute traumatic brain injury with the hormone progesterone provides no significant benefit to patients when compared with placebo, a NIH-funded phase III clinical trial has concluded.
The results are scheduled for publication Dec. 10 in the New England Journal of Medicine.
The study, named ProTECT III, involved 49 trauma centers across the United States between July 2009 and November 2013. The study was originally planned to include 1,140 patients, but was stopped after 882 patients because safety monitors determined that additional enrollment would be ...
Study concludes that progesterone administered to severe TBI patients, showed no benefit
2014-12-11
A study concluded that after five days of treatment with a novel formulation of progesterone acutely administered to patients with severe traumatic brain injury (TBI), showed no clinical benefits.
The paper entitled, "A Clinical Trial of Progesterone for Severe Traumatic Brain Injury," will be published online in The New England Journal of Medicine, December 10, 2014.
This trial, referred to as SyNAPSe, reports on a large prospective randomized clinical trial that investigated the effects of progesterone administered to severe TBI patients," said Raj K. Narayan, ...
Commonly prescribed painkiller not effective in controlling lower back pain
2014-12-10
A new study out today in the journal Neurology shows that pregabalin is not effective in controlling the pain associated with lumbar spinal stenosis, the most common type of chronic lower back pain in older adults.
"Chronic low back pain is one of the most common reasons why older adults go to the doctor and lumbar stenosis is the leading indication for surgery in this age group," said John Markman, M.D., director of the Translational Pain Research Program in the University of Rochester Department of Neurosurgery and lead author of the study. "While physicians have ...
Study finds eczema, short stature not associated overall
2014-12-10
Eczema, an itchy chronic inflammatory disease of the skin, was not associated overall with short stature in an analysis of data from several studies, although a small group of children and adolescents with severe eczema who do not get enough sleep may have potentially reversible growth impairment, according to a study published online by JAMA Dermatology.
Eczema (atopic dermatitis) affects about 10 percent of children and adults in the United States. The disease results in a number of conditions that could impact growth in children and adolescents, such as sleep impairment, ...
Islet cell transplantation after pancreas removal may help preserve normal blood sugar
2014-12-10
Surgery to remove all or part of the pancreas and then transplant a patient's own insulin-producing islet cells appears to be a safe and effective final measure to alleviate pain from severe chronic pancreatitis and to help prevent surgically induced diabetes, according to a report published online by JAMA Surgery.
Chronic pancreatitis (CP) is an inflammatory disease that over time leads to loss of function of the pancreas and manifests with intractable pain, malabsorption and diabetes. While medical management and pain control are the initial approaches to CP, some patients ...
LAST 30 PRESS RELEASES:
Male athletes need higher BMI to define overweight or obesity
How thoughts influence what the eyes see
Unlocking the genetic basis of adaptive evolution: study reveals complex chromosomal rearrangements in a stick insect
Research Spotlight: Using artificial intelligence to reveal the neural dynamics of human conversation
Could opioid laws help curb domestic violence? New USF research says yes
NPS Applied Math Professor Wei Kang named 2025 SIAM Fellow
Scientists identify agent of transformation in protein blobs that morph from liquid to solid
Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss
Research identifies key enzyme target to fight deadly brain cancers
New study unveils volcanic history and clues to ancient life on Mars
Monell Center study identifies GLP-1 therapies as a possible treatment for rare genetic disorder Bardet-Biedl syndrome
Scientists probe the mystery of Titan’s missing deltas
Q&A: What makes an ‘accidental dictator’ in the workplace?
Lehigh University water scientist Arup K. SenGupta honored with ASCE Freese Award and Lecture
Study highlights gaps in firearm suicide prevention among women
People with medical debt five times more likely to not receive mental health care treatment
Hydronidone for the treatment of liver fibrosis associated with chronic hepatitis B
Rise in claim denial rates for cancer-related advanced genetic testing
Legalizing youth-friendly cannabis edibles and extracts and adolescent cannabis use
Medical debt and forgone mental health care due to cost among adults
Colder temperatures increase gastroenteritis risk in Rohingya refugee camps
Acyclovir-induced nephrotoxicity: Protective potential of N-acetylcysteine
Inhibition of cyclooxygenase-2 upregulates the nuclear factor erythroid 2-related factor 2 signaling pathway to mitigate hepatocyte ferroptosis in chronic liver injury
AERA announces winners of the 2025 Palmer O. Johnson Memorial Award
Mapping minds: The neural fingerprint of team flow dynamics
Patients support AI as radiologist backup in screening mammography
AACR: MD Anderson’s John Weinstein elected Fellow of the AACR Academy
Existing drug has potential for immune paralysis
Soft brainstem implant delivers high-resolution hearing
Uncovering the structural and regulatory mechanisms underlying translation arrest
[Press-News.org] German breast group study: Superior activity for nab-paclitaxel in early breast cancerStudy showing superior activity for nab-paclitaxel vs paclitxel in early breast cancer at San Antonio Breast Cancer Symposium, General Session 2, 4:45 PM CT, Wed, Dec 10th