PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Depletion of naive T cells from stem cell grafts limits chronic graft-versus host disease

2015-06-08
(Press-News.org) Stem cell transplantation is used to treat hematologic malignancies, such as leukemia. Patients that receive donor cells are at risk of developing graft-versus host disease (GVHD). This potentially fatal complication results when naive T cells generated from the graft promote an immune response that attacks the recipient's tissues. Prophylactic treatment with immunosuppressive drugs is currently used to limit GVHD but does not reliably prevent disease. In mouse models, depletion of naive T cells from the stem cell graft prior to transplant reduces the occurrence and severity of GVHD. A new study in the Journal of Clinical Investigation evaluates GVHD in a small set of patients with leukemia that received stem cell grafts that had been depleted of naïve T cells prior to transplantation. Marie Bleakley and colleagues at the Fred Hutchinson Cancer Research Center showed that reduction of naïve T cells in the donor graft markedly reduces the occurrence of chronic GVHD disease in patients. There was no reduction in the overall rate of acute GVHD occurrence in these patients. However, acute GVHD in these recipients was generally responsive to corticosteroid therapy. The results of this study support depletion of naïve T cells from stem cell grafts prior to transplantation as a potential treatment option to limit chronic GVHD in patients.

INFORMATION:

Title:

Outcomes of acute leukemia patients transplanted with naive T cell depleted stem cell grafts

Contact:

Marie Bleakley
mbleakle@fhcrc.org
Fred Hutchinson Cancer Research Center

View this article at:http://www.jci.org/articles/view/81229?key=6fa7899f2803ed06e557



ELSE PRESS RELEASES FROM THIS DATE:

Who your doctor is could dictate how you're cared for at end of life

2015-06-08
New research from Brigham and Women's Hospital finds that physician characteristics are the strongest predictor of whether a patient will be referred to hospice care. Individual physicians are widely believed to influence the kind of care their patients receive at the end of life, but to date, there is little scientific evidence to support this belief. New research from Brigham and Women's Hospital (BWH) indicates that the individual physician a patient sees is the strongest known predictor of whether or not he or she will enroll in hospice care, outweighing other known ...

Restraining health care prices requires workforce productivity gains, not wage cuts alone

2015-06-08
A new study by NYU Wagner Dean and Professor of Public Service Sherry A. Glied and two additional researchers sees little evidence to support the belief that healthcare workers' wage levels are responsible for the rising cost of health care services in the U.S. Effective cost containment will require not wage reductions alone, but broad productivity gains derived from the use of fewer or less-skilled employees to produce any given service, the study concludes. Published today (June 8) in the June edition of the peer-reviewed journal Health Affairs, the paper by ...

Important new research on early palliative care for advanced cancer patients published

2015-06-08
Researchers at Trinity College Dublin and Mount Sinai in New York have just published new research which for the first time provides strong evidence on the economic benefits of early palliative care intervention for people with an advanced cancer diagnosis. Their findings were published today in the highly esteemed international peer reviewed Journal of Clinical Oncology. Previous research has shown the clinical benefits of early palliative care, but this new study robustly demonstrated how early access to expert palliative care decision making resulted in very significant ...

Certain donors with high T cell counts make better match for stem-cell transplant patients

2015-06-08
PHILADELPHIA-- Using a simple blood test to measure the T lymphocyte count in donors for stem cell transplants may help identify the best match for patients in need of an allogeneic stem cell transplant, suggests a new study in the Journal of Clinical Oncology from researchers at the Abramson Cancer Center (ACC) of the University of Pennsylvania. Typically, matched siblings have been preferred over unrelated donors. This study shows that older patients who received stem cells from younger, unrelated donors with higher numbers of so-called killer T cells (CD8 cells) had ...

Early attention to quality of life reduces hospital costs for advanced cancer patients

2015-06-08
New York, NY-- Earlier introduction of palliative care for patients hospitalized with advanced cancer is associated with lower hospital costs, according to a new study published in the Journal of Clinical Oncology. The findings support a growing body of evidence that suggests that early provision of palliative care not only enhances the quality of medical care received by patients and families with serious illness, but does so at a lower cost than traditional oncologic care. The observational study, funded by the National Cancer Institute and National Institute for Nursing ...

The health effects of homophobia

2015-06-08
New Haven, Conn. -- Gay and bisexual men living in European countries with strong attitudes and policies against homosexuality are far less likely to use HIV-prevention services, test for HIV, and discuss their sexuality with health providers, according to research led by Yale School of Public Health (YSPH). The study is published online in the journal AIDS. Attitudes about homosexuality vary greatly across Europe, noted YSPH associate professor and lead author John Pachankis and his colleagues. The research team wanted to investigate the impact of homophobia on gay and ...

Bacterial sepsis protein may inhibit cancer cell growth

2015-06-08
CHICAGO -- A toxin secreted by Vibrio vulnificus, a water and food-borne bacteria that can cause rapidly lethal infections in persons with liver disease, has potential to prevent the growth of tumors, according to a new study by Northwestern Medicine scientists. Karla Satchell, a professor in microbiology-immunology at Northwestern University Feinberg School of Medicine, and her team demonstrated in a paper in Nature Communications, that a multifunctional-autoprocessing repeats-in-toxin (MARTX) protein from Vibrio vulnificus can inhibit tumor cell growth by cutting the ...

Quenched glasses, asteroid impacts, and ancient life on Mars

Quenched glasses, asteroid impacts, and ancient life on Mars
2015-06-08
Boulder, Colo., USA - Quenched glasses formed by asteroid impacts can encapsulate and preserve biological material for millions of years on Earth, and can also serve as a substrate for microbial life. These impact glasses are thus an important target to search for signs of ancient life on Mars, but until now they have not been definitively detected on the martian surface. In this study, Kevin Cannon and John Mustard used orbital remotely sensed data to investigate spectral signatures of geologic units on Mars that were formed during impacts (impactites). Using spectral ...

Researchers find everyone has a bias blind spot

2015-06-08
PITTSBURGH--It has been well established that people have a "bias blind spot," meaning that they are less likely to detect bias in themselves than others. However, how blind we are to our own actual degree of bias, and how many of us think we are less biased than others have been less clear. Published in Management Science, new research from Carnegie Mellon University, the City University London, Boston University and the University of Colorado, Boulder, has developed a tool to measure the bias blind spot, and reveals that believing that you are less biased than your ...

People at risk of hoarding disorder may have serious complaints about sleep

2015-06-08
DARIEN, IL - A new study suggests that those at risk of hoarding disorder may have serious complaints about sleep. Results show that participants at risk of hoarding disorder scored significantly higher on the Sleep Habits Survey (SH) and on three sub-scales of the Pittsburgh Sleep Quality Index (PSQI), including sleep latency; sleep disturbances and daytime disturbances. "Hoarders typically have problems with decision making and executive function; poor sleep is known to compromise cognition generally, so if hoarders have cluttered/unusable bedrooms (and less comfortable, ...

LAST 30 PRESS RELEASES:

Bipolar disorder heterogeneity decoded: transforming global psychiatric treatment approaches

Catching Alport syndrome through universal age-3 urine screening

Instructions help you remember something better than emotions or a good night’s sleep

Solar energy is now the world’s cheapest source of power, a Surrey study finds

Scientists reverse Alzheimer’s in mice using nanoparticles

‘Good’ gut bacteria boosts placenta for healthier pregnancy

USC team demonstrates first optical device based on “optical thermodynamics”

Microplastics found to change gut microbiome in first human-sample study

Artificially sweetened and sugary drinks are both associated with an increased risk of liver disease, study finds

Plastic in the soil, but not as we know it: Biodegradable microplastics rewire carbon storage in farm fields

Yeast proteins reveal the secrets of drought resistance

Psychiatry, primary care, and OB/GYN subspecialties hit hardest by physician attrition

New Canadian study reveals where HIV hides in different parts of the body

Lidocaine poisonings rise despite overall drop in local anesthetic toxicity

Politics follow you on the road

Scientists blaze new path to fighting viral diseases

The mouse eye as a window to spotting systemic disease

AI and the Future of Cancer Research and Cancer Care to headline October 24 gathering of global oncology leaders at the National Press Club: NFCR Global Summit to feature top scientists, entrepreneurs

FDA clears UCLA heart tissue regeneration drug AD-NP1 for clinical trials

Exploring the therapeutic potential of cannabidiol for Alzheimer's

We need a solar sail probe to detect space tornadoes earlier, more accurately, U-M researchers say

Acute myeloid leukemia (AML): Disease risk but not remission status determines transplant outcomes – new ASAP long-term results

Sperm microRNAs: Key regulators of the paternal transmission of exercise capacity

Seeing double: Clever images open doors for brain research

Inhaler-related greenhouse gas emissions in the US

UCLA Health study finds inhalers for asthma and COPD drive significant greenhouse gas emissions

A surgical handover system for patient physiology and safety

Cardiovascular health changes in young adults and risk of later-life cardiovascular disease

Nurse workload and missed nursing care in neonatal intensive care units

How to solve the remote work stalemate – dissertation offers tools for successful hybrid work

[Press-News.org] Depletion of naive T cells from stem cell grafts limits chronic graft-versus host disease