(Press-News.org) SAN FRANCISCO - Innovative vaccine and tumor research will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference (NBC). The meeting takes place Monday, June 8- Wednesday, June 10 at the San Francisco Marriott Marquis.
This year's conference is organized into five meeting workstreams: Chemistry, Manufacturing, and Controls (CMC) including Formulation, Characterization, Stability and Biomanufacturing; Research and Discovery; Clinical Pharmacology, Pharmacokinetic/Pharmacodynamic (PK/PD), and Bioanalytics; Regulatory; and Biomarkers and Imaging. Submitted abstracts showcase the breadth and depth of the research being presented, as well as the global reach of AAPS. Research highlights include:
Capture of Circulating Tumor Cells with Dual Antibody-Coated Nanomaterial for Cancer Metastasis Prevention.
Nearly all cancers can form metastic tumors, according to the National Cancer Institute. Jingjing Xie, a student at Fuzhou University in Fujian, China, is working to design safe and effective antibody-coated nanomaterials for capturing and restraining the rare circulating tumor cells (CTCs) for cancer metastasis prevention.
The study, for the first time, elucidates that dual antibody-coated nanomaterial can exhibit a significantly enhanced
specificity in capturing and down-regulating CTCs in the absence or presence of interfering blood cells in comparison with
their single antibody-coated counterparts.
Work is being presented June 8, 2015 at 10:00 a.m. PST.
Penfluridol Suppresses In Vivo Pancreatic Tumor Growth by Autophagy Mediated Apoptosis.
Pancreatic cancer is the most aggressive cancer characterized by metastasis progression and has developed resistance to current FDA therapies. There are estimated to be about 48,960 new cases of pancreatic cancer in 2015, and it is the fourth most common cause of death every year in the U.S.
Alok Ranjan, a graduate student at Texas Tech University Health Sciences Center School of Pharmacy and his team are conducting important research using the antipsychotic drug penfluridol to suppress pancreatic tumor growth by autophagy mediated apoptosis.
Work is being presented on June 10, 2015 at 10:00 a.m. PST.
Protective Immunity against Malaria after Vaccination with Mannosylated Liposomes Encapsulating Whole Parasites.
According to the CDC, there were an estimated 198 million cases of malaria worldwide and 500,000 people in 2013. While malaria is one of the oldest diseases in the world, there are no vaccines currently available. Ashwin Kumar Giddam and his team at the University of Queensland in Australia are working to provide immunity against malaria by developing a liposome vaccine formulation, which increased the survival rate of mice challenged with infectious parasites.
Work is being presented June 9, 2015 at 10:00 a.m. PST.
INFORMATION:
About AAPS: The American Association of Pharmaceutical Scientists is a professional, scientific society of approximately 10,000 members employed in academia, industry, government and other research institutes worldwide. Founded in 1986, AAPS provides a dynamic international forum for the exchange of knowledge among scientists to serve the public and enhance their contributions to health. AAPS offers timely scientific programs, on-going education, information resources, opportunities for networking, and professional development.
About the AAPS National Biotechnology Conference: The 2015 AAPS National Biotechnology Conference (NBC) will gather scientists from industry, government, and academia for three days of educational offerings specifically geared toward the biotechnology sector of the pharmaceutical sciences. Follow us on social media; official hashtag for the meeting is #2015NBC. Visit http://www.aaps.org/nationalbiotech/ for more information.
Editor's Note: Registration is complimentary for members of the media. All abstracts presented are available upon request. To register for the meeting or set up an interview with an expert, please contact Stacey May on-site at (703) 459-7677.
Was it a massive migration? Or was it rather a slow and persistent seeping of people, items and ideas that laid the foundation for the demographic map of Europe and Central Asia that we see today? The Bronze Age (about 5,000 - 3,000 years ago) was a period with large cultural upheavals. But just how these upheavals came to be have remained shrouded in mystery.
Assistant Professor Morten Allentoft from the Centre for GeoGenetics at the Natural History Museum of Denmark at the University of Copenhagen is a geneticist and is first author on the paper in Nature. He says:
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An international team of scientists has found a dramatic ice sheet collapse at the end of the ice age before last caused widespread climate changes and led to a peak in the sea level well above its present height.
The team found the events 135,000 years ago caused the planet to warm in a different way to the end of the most recent ice age about 20,000 to 10,000 years ago.
The findings will help scientists understand the processes that control Earth's dramatic climate changes, said the leader of the study, Dr Gianluca Marino of The Australian National University (ANU).
"We ...
Several neurodegenerative disorders are caused by aggregates of a single protein known as alpha-synuclein. In collaboration with CNRS and the University of Antwerp, KU Leuven neurobiologists have discovered that the shape of these aggregates - 'cylinders' or 'ribbons' - determines whether a patient develops Parkinson's disease or Multiple System Atrophy, respectively.
Typical of neurodegenerative disorders is the disrupted communication between brain cells together with a loss of cells in specific brain regions. For some brain diseases this phenomenon is linked to a ...
The discovery of how a group of bacteria rapidly adapts to changing growth conditions could have implications for future antibiotic development, according to research at the University of Oxford and the University of York.
Led by Professor Colin Kleanthous at Oxford and Dr Christoph Baumann at York, the research which also involved key collaborators Mark Sansom at Oxford and Jacob Piehler at the University of Osnabrück, is published in Nature.
Gram-negative bacteria are a major cause of disease, in part because they have a robust outer membrane that protects ...
A University of Manchester led trial of a new psoriasis drug has resulted in 40 percent of people showing a complete clearance of psoriatic plaques after 12 weeks of treatment and over 90 percent showing improvement.
The research tested 2,500 people with psoriasis. Half were given a new drug - ixekizumab - either once every two or four weeks. The other half were given a placebo or a widely used drug for psoriasis called etanercept.
The ixekizumab groups showed quick and extensive improvements in their condition, outperforming the groups on placebo or etanercept. Around ...
wo NASA satellites provided a look inside and outside of Tropical Cyclone Ashobaa. NASA and JAXA's GPM satellite observed rainfall rates and cloud heights identifying powerful thunderstorms within the cyclone, and NASA's Aqua satellite provided an overall look at Ashobaa's cloud extent.
The Global Precipitation Measurement (GPM) core observatory had an excellent view of Tropical Cyclone Ashobaa in the Arabian Sea over on June 8, 2015 at 2131 UTC (5:31 p.m. EDT). As expected, Tropical Cyclone Ashobaa was more powerful than when seen by GPM earlier in the day. GPM's Microwave ...
Genetically modified fish that overexpress growth hormone have been created for more than 25 years, but unlike many domesticated crops, transgenic fish have yet to enter commercial production. Because of the difficulty inherent in eradicating an established fish population, efforts are under way to model the threat posed by possible invasions.
In an article for an upcoming issue of BioScience, a team of government and academic researchers, led by Robert Devlin of Fisheries and Oceans Canada, examined the possible outcomes of an accidental release of transgenic fish. Their ...
The air around us is a chaotic superhighway of molecules whizzing through space and constantly colliding with each other at speeds of hundreds of miles per hour. Such erratic molecular behavior is normal at ambient temperatures.
But scientists have long suspected that if temperatures were to plunge to near absolute zero, molecules would come to a screeching halt, ceasing their individual chaotic motion and behaving as one collective body. This more orderly molecular behavior would begin to form very strange, exotic states of matter -- states that have never been observed ...
Most galaxies are clumped together in groups or clusters. A neighboring galaxy is never far away. But this galaxy, known as NGC 6503, has found itself in a lonely position, at the edge of a strangely empty patch of space called the Local Void.
The Local Void is a huge stretch of space that is at least 150 million light-years across. It seems completely empty of stars or galaxies. The galaxy's odd location on the edge of this never-land led stargazer Stephen James O'Meara to dub it the "Lost-In-Space galaxy" in his 2007 book, Hidden Treasures.
NGC 6503 is 18 million ...
New research from UBC and the Child & Family Research Institute at BC Children's Hospital shows that risky outdoor play is not only good for children's health but also encourages creativity, social skills and resilience.
The findings, published in the International Journal of Environmental Research and Public Health, found that children who participated in physical activity such as climbing and jumping, rough and tumble play and exploring alone, displayed greater physical and social health.
"We found that play environments where children could take risks promoted increased ...
