PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Heart failure readmissions reduced with new optimization approach

2015-06-10
(Press-News.org) People hospitalized for heart failure had a significantly lower chance of being readmitted within 30 days of discharge when treated with a cardiac resynchronization therapy device, or CRT, equipped with an algorithm to automatically deliver and adjust therapy when compared to those receiving the standard CRT optimized with echocardiography, according to a study today in JACC: Heart Failure.

A CRT device is a defibrillator that sends electrical impulses to the heart to help the chambers beat in synchronization and improves the heart's pumping function. It is an established treatment for patients with heart failure, and while it has been proven to provide many benefits, including an improved quality of life and reduced risk of death, not all patients respond to CRT.

In this study, researchers analyzed data from the Adaptive CRT trial to determine rates of hospital readmissions for heart failure patients with a CRT device. For heart failure hospitalizations the 30-day readmission rate was 19.1 percent in patients with the AdaptivCRT algorithm and 35.7 percent in patients with echo. For all-cause hospitalization, the 30-day readmission rate was 14.8 percent with the algorithm compared to 24.8 percent with echo. The risk reduction for readmission was also signficantly reduced beyond 30 days.

Heart failure was one of the first hospitalization types to be identified under the Hospital Readmissions Reduction Program, which reduces Medicare inpatient payments when a patient is readmitted to the hospital within 30 days of discharge for certain conditions. According to the study, the CRT algorithm showed a significant reduction in 30-day readmission rates, making it a potential safe and effective strategy to reduce readmissions and overall health care costs.

INFORMATION:

The American College of Cardiology is a 49,000-member medical society that is the professional home for the entire cardiovascular care team. The mission of the college is to transform cardiovascular care and to improve heart health. The ACC leads in the formation of health policy, standards and guidelines. The college operates national registries to measure and improve care, provides professional medical education, disseminates cardiovascular research and bestows credentials upon cardiovascular specialists who meet stringent qualifications. For more information, visit www.acc.org.



ELSE PRESS RELEASES FROM THIS DATE:

Low levels of hormone in African-Americans may increase hypertension

2015-06-10
Although hypertension is more common in African-Americans, they have significantly lower levels of a hormone produced in response to cardiac stress than white and Hispanic individuals, a finding that may indicate a target for prevention or treatment of heart disease, according to a study published today in JACC: Heart Failure. Using data from the Dallas Heart Study, researchers assessed 3,148 patients and examined the association between race and ethnicity and levels of natriuretic peptides -- which are hormones produced in response to increased cardiac wall stress common ...

'Mutation accelerator' identified in gene mutation linked to common adult leukemia

2015-06-10
In preliminary experiments with mice and lab-grown cells, Johns Hopkins Kimmel Cancer Center scientists have found that a protein-signaling process accelerates the work of the gene most frequently mutated in a common form of adult leukemia and is likely necessary to bring about the full-blown disease. The Kimmel team, in a report published in the June 10 issue of Science Translational Medicine, demonstrated the impact of the so-called Hedgehog protein signaling pathway by successfully using a combination of two drugs to both block the activity of the mutated gene, called ...

Gold-standard clinical trials fail to capture how behavior changes influence treatment

Gold-standard clinical trials fail to capture how behavior changes influence treatment
2015-06-10
PRINCETON, N.J.--Double-blind clinical trials for new drugs are considered the "gold standard" of medical research because they're designed to determine the efficacy of a treatment free from doctor and participant bias. But one effect these trials fail to measure is how a medication's performance can vary based on patients' lifestyle choices, especially if patients change their habits because they are anticipating treatment, according to a new study published in PLOS ONE. A recent meta-analysis of six clinical trials, led by researchers from Princeton University, the ...

Plants may run out of time to grow under ongoing climate change

2015-06-10
A key potential 'benefit' of global warming--namely, that plants at northern latitudes will thrive in a warmer world--is challenged by a new study released by University of Hawai'i scientists today. The prevailing assumption ignores the fact that plants in the North will remain limited by solar radiation, curbing positive effects of warming and additional CO2 availability. In addition, that same warming could surpass plant temperature tolerances in tropical areas around the world, and further be accompanied by drought. "Those that think climate change will benefit plants ...

Risk for sleep disorders among college freshmen may predict retention, success

2015-06-10
DARIEN, Ill. -- A new study suggests that the risk for sleep disorders among college freshmen may be a predictor of retention and academic success. Results show that students at risk for a sleep disorder were more likely to leave the institution over the three-year period, although this association was weakened when covariates were included. Risk for sleep disorder also predicted grade point average (GPA) at the end of the first and second years. 'A survey that screens for sleep disorders administered when students first enter college may identify a potentially modifiable ...

Clinical trial launched to assess safety and efficacy of autism drug treatment

2015-06-10
Researchers at the University of California, San Diego School of Medicine have launched a clinical trial to investigate the safety and efficacy of an unprecedented drug therapy for autism. The phase 1 clinical trial, which is recruiting 20 qualifying participants, will evaluate suramin -- a century-old drug still used for African sleeping sickness -- as a novel treatment for children with a diagnosis of Autism Spectrum Disorder (ASD). Previous published research by Robert K. Naviaux, M.D., Ph.D., professor of medicine, pediatrics and pathology at UC San Diego School of ...

Fragile X proteins involved in proper neuron development

2015-06-10
MADISON, Wis. -- Fragile X syndrome is the most common inherited intellectual disability and the greatest single genetic contributor to autism. Unlocking the mechanisms behind fragile X could make important revelations about the brain. In a new study published June 4 in the journal Cell Reports, researchers from the University of Wisconsin-Madison Waisman Center and Department of Neuroscience show that two proteins implicated in fragile X play a crucial role in the proper development of neurons in mice. They also show that while the two proteins act through distinct mechanisms ...

Obesity linked to adrenal disorder in teens may increase risk for cardiovascular disease

2015-06-10
Researchers at Children's Hospital Los Angeles have demonstrated that adolescents and young adults with congenital adrenal hyperplasia (CAH) have significantly increased amounts of abdominal fat tissue, placing them at greater risk for harmful conditions linked to obesity, including cardiovascular disease (CVD). Their study, which reveals new information about the role of abdominal fat in patients with CAH and points to a need for targeted prevention and therapeutics to avoid these adverse effects, will be published online June 10, 2015 by The Journal of Clinical Endocrinology ...

Cutting-edge research unveiled at 2015 AAPS National Biotechnology Conference

2015-06-10
SAN FRANCISCO - Innovative vaccine and tumor research will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference (NBC). The meeting takes place Monday, June 8- Wednesday, June 10 at the San Francisco Marriott Marquis. This year's conference is organized into five meeting workstreams: Chemistry, Manufacturing, and Controls (CMC) including Formulation, Characterization, Stability and Biomanufacturing; Research and Discovery; Clinical Pharmacology, Pharmacokinetic/Pharmacodynamic (PK/PD), and Bioanalytics; Regulatory; ...

When modern Eurasia was born

When modern Eurasia was born
2015-06-10
Was it a massive migration? Or was it rather a slow and persistent seeping of people, items and ideas that laid the foundation for the demographic map of Europe and Central Asia that we see today? The Bronze Age (about 5,000 - 3,000 years ago) was a period with large cultural upheavals. But just how these upheavals came to be have remained shrouded in mystery. Assistant Professor Morten Allentoft from the Centre for GeoGenetics at the Natural History Museum of Denmark at the University of Copenhagen is a geneticist and is first author on the paper in Nature. He says: - ...

LAST 30 PRESS RELEASES:

New drug-eluting balloon may be as safe and effective as conventional metal stents for repeat percutaneous coronary interventions

Effectiveness and cost-effectiveness of automated external defibrillators in private homes

University of Phoenix College of Social and Behavioral Sciences leadership publishes white paper on trauma-informed education

Microbial iron mining: turning polluted soils into self-cleaning reactors

Molecular snapshots reveal how the body knows it’s too hot

Analysis finds alarming rise in severe diverticulitis among younger Americans

Mitochondria and lysosomes reprogram immune cells that dampen inflammation

Cockroach infestation linked to home allergen, endotoxin levels

New biochar-powered microbial systems offer sustainable solution for toxic pollutants

Identifying the best high-biomass sorghum hybrids based on biomass yield potential and feedstock quality affected by nitrogen fertility management under various environments

How HIV’s shape-shifting protein reveals clues for smarter drug design

Study identifies viral combinations that heighten risk of severe respiratory illnesses in infants

Aboveground rather than belowground productivity drives variability in miscanthus × giganteus net primary productivity

Making yeast more efficient 'cell factories' for producing valuable plant compounds

Aging in plain sight: What new research says the eyes reveal about aging and cardiovascular risk

Child welfare system involvement may improve diagnosis of developmental delays

Heavier electric trucks could strain New York City’s roads and bridges, study warns

From womb to world: scientists reveal how maternal stress programs infant development

Bezos Earth Fund grants $2M to UC Davis and American Heart Association to advance AI-designed foods

Data Protection is transforming humanitarian action in the digital age, new book shows

AI unlocks the microscopic world to transform future manufacturing

Virtual reality helps people understand and care about distant communities

Optica Publishing Group announces subscribe to open pilot for the Journal of the Optical Society of America B (JOSA B)

UNF partners with Korey Stringer Institute and Perry Weather to open heat exercise laboratory on campus

DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their retreat from Russia

Study suggests two unsuspected pathogens struck Napoleon's army during the retreat from Russia in 1812

The 25-year incidence and progression of hearing loss in the Framingham offspring study

AI-driven nanomedicine breakthrough paves way for personalized breast cancer therapy

Fight or flight—and grow a new limb

Augmenting electroencephalogram transformer for steady-state visually evoked potential-based brain–computer interfaces

[Press-News.org] Heart failure readmissions reduced with new optimization approach