(Press-News.org) Here is a link to watch a video interview with Dr. Beatrice Aramini about this topic on the Oncotarget YouTube Channel
Oncotarget published "Cancer stem cells and macrophages: molecular connections and future perspectives against cancer" which reported that Cancer stem cells have been considered the key drivers of cancer initiation and progression due to their unlimited self-renewal capacity and their ability to induce tumor formation.
Macrophages, particularly tumor-associated macrophages, establish a tumor microenvironment to protect and induce CSCs development and dissemination.
Many studies in the past decade have been performed to understand the molecular mediators of CSCs and TAMs, and several studies have elucidated the complex crosstalk that occurs between these two cell types.
The aim of this Oncotarget review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies.
The aim of this Oncotarget review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies
Dr. Beatrice Aramini from The University of Modena and Reggio Emilia said, "Cancer stem cells (CSCs) constitute a cancer cell subpopulation similar to the other stem cell types in terms of self-renewal and multilineage differentiation potential but drive tumor development besides heterogeneity and dissemination of cancer cells."
The role of ALDH as a possible marker for lung cancer stem cell: as ALDH cells in cancer cell lines, as well as those extracted from lung cancer tissue, for the properties that it showed as forming spheres in culture tumor cells lines as well as in cells extracted from lung cancer tissue.
However, currently there is no specific or standard marker in lung cancer cells that can define this subpopulation of cells, probably due to the complex localization of these markers and their epigenetic regulation.
A theory regarding the role of CSCs in cancer progression is based on the premise that tumor tissue is hierarchically organized into different types of cells wherein CSC subpopulation is at the top of this hierarchy, with the other levels consisting of more differentiated tumor cells or cells with a limited proliferative potential.
Another essential characteristic that places CSCs at the top of the tumor cell hierarchy is their unlimited proliferation potential, which allows them to repopulate the tumor even if bulk tumor cells have been removed.
The Aramini Research Team concluded in their Oncotarget Review, "Generating new information about the interaction between TAMs and CSCs will be one of the most important challenges for the development of more effective targeted cancer therapies."
Sign up for free Altmetric alerts about this article
DOI - https://doi.org/10.18632/oncotarget.27870
Full text - https://www.oncotarget.com/article/27870/text/
Correspondence to - Beatrice Aramini - beatrice.aramini@unimore.it
Keywords -
cancer stem cells,
macrophages,
future perspectives,
cancer,
target treatments
About Oncotarget
Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.
To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:
SoundCloud - https://soundcloud.com/oncotarget
Facebook - https://www.facebook.com/Oncotarget/
Twitter - https://twitter.com/oncotarget
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls
For the first time, physicists from the University of Basel have produced a graphene compound consisting of carbon atoms and a small number of nitrogen atoms in a regular grid of hexagons and triangles. This honeycomb-structured "kagome lattice" behaves as a semiconductor and may also have unusual electrical properties. In the future, it could potentially be used in electronic sensors or quantum computers.
Researchers around the world are searching for new synthetic materials with special properties such as superconductivity -- that is, the conduction of electric current without resistance. These new substances are an important step in the development ...
Climate change is rapid in the Arctic. As the climate warms, shrubs expand towards higher latitudes and altitudes. Researcher Julia Kemppinen together with her colleagues investigated the impacts of dwarf shrubs on tundra soils in the sub-Arctic Fennoscandia.
The study revealed that the dominance of dwarf shrubs impacts soil microclimate and carbon stocks. Microclimate describes the moisture and temperature conditions close to ground surface. Shrubs are the largest plant life form in the Arctic, and in comparison, to other arctic plants, shrubs use more water and cast more shade.
"The results indicate ...
WASHINGTON -- When people pause before replying to a question, even for just a few seconds, their answers are perceived to be less sincere and credible than if they had replied immediately, according to research published by the American Psychological Association.
And the longer the hesitation, the less sincere the response appears.
"Evaluating other people's sincerity is a ubiquitous and important part of social interactions," said lead author Ignazio Ziano, PhD, of Grenoble Ecole de Management. "Our research shows that response speed is an important cue on which people base their sincerity inferences."
The research was published in the Journal of Personality and Social Psychology.
Researchers ...
Cancer is one of the most thought-provoking healthcare problems throughout the world. The development of therapeutic agents with highly selective anti-cancer activities is increasingly attractive due to the lack of tumor selectivity of conventional treatments.
Scientists at Japan Advanced Institute of Science and Technology (JAIST) have created a photosynthetic bacteria-based cancer optotheranostics (Figure 1).
Discovered by Associate Professor Eijiro Miyako and his team from JAIST, natural purple photosynthetic bacteria (PPSB) can play a key role as a highly active cancer immunotheranostics agent that uses the bio-optical-window I and II near-infrared (NIR) light thanks to the light harvesting nanocomplexes in microbial ...
There is no coat colour that distinguishes dingoes from dingo-dog hybrids, a study involving UNSW Sydney has found.
The Centre for Ecosystem Science research suggests that animals assumed to be dingo-dog hybrids based on their coat colour and culled may have been pure dingoes.
"We actually found pure dingoes that had a brindle, black and tan, patchy or sable coat colour," Dr Kylie Cairns, a conservation biologist from UNSW Sydney and co-author of the study said.
"So that's showing that really dingoes are much more variable than we think and seeing an animal with an odd coat colour doesn't immediately mean that it's a hybrid.
"Using coat colour to decide what animals should be culled is not a very good idea."
The study follows 2019 research by UNSW and collaborators which found ...
San Antonio, Texas (February 15, 2020) - Researchers at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute (Texas Biomed) may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency. Co-led by Deepak Kaushal, Ph.D., Director of the SNPRC, this is the first study that used scRNAseq to study TB in macaques in depth. Results from the study were published ...
Scientists of Kemerovo State University, within the framework of the Russian Scientific Foundation grant "Cultivation of isolated cells and organs of rare and endemic medicinal plants of Siberia and the Far East in vitro as a biotechnological method for obtaining biologically active substances", are investigating the fundamental principles of in vitro cultivation of isolated cells and organs of rare medicinal plants - producers of biologically active substances with cytotoxic, antioxidant and antimicrobial properties. One of the urgent problems of medicine and biology is the search and use of plant objects as medicines. The unfavorable environmental situation and the increasing need for medicinal raw materials create its shortage. A new solution ...
In our ongoing struggle to reduce the usage of fossil fuel, technology to directly convert the world's waste heat into electricity stands out as very promising. Thermoelectric materials, which carry out this energy conversion process, have, thus, recently become the focus of intense research worldwide. Of the various potential candidates applicable at a broad range of temperatures, between 30 and 630 °C, lead telluride (PbTe) offers the best thermoelectric performance. Unfortunately, the outstanding qualities of PbTe are eclipsed by the toxic nature of lead, driving researchers to look into safer thermoelectric semiconductors.
Tin telluride (SnTe) could be an ...
Ben-Gurion University Researchers Uncover a Catch-22 When It Comes to Social Media Online Support Groups and Privacy Concerns
BEER-SHEVA, Israel...February 16, 2021- People who seek support online social media groups may end up not getting the help they need due to privacy concerns, according to a new study by Ben-Gurion University of the Negev (BGU) and Gutenberg University in Sweden.
The new research, published in END ...
Could long-distance interactions between individual molecules forge a new way to compute?
Interactions between individual molecules on a metal surface extend for surprisingly large distances - up to several nanometers.
A new study, just published, of the changing shape of electronic states induced by these interactions, has potential future application in the use of molecules as individually addressable units.
For example, in a future computer based on this technology, the state of each individual molecule could be controlled, mirroring binary operation of transistors in current computing.
MEASURING SOCIALLY-DISTANT MOLECULAR INTERACTIONS ON A METAL SURFACE
The Monash-University of Melbourne collaboration studied the electronic properties of ...
