PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Study examines heart and kidney outcomes of adults with nephrotic syndrome

Patients face high risks of kidney failure and cardiovascular problems

2021-06-19
(Press-News.org) Highlights Primary nephrotic syndrome is characterized by high urinary excretion of protein, low protein in the blood, high cholesterol, and swelling in the arms and legs. A new analysis highlights the high risk of kidney failure and different cardiovascular complications in patients with primary nephrotic syndrome.

Washington, DC (June 18, 2021) -- A form of kidney disease called primary nephrotic syndrome is characterized by high urinary excretion of protein, low protein in the blood, high cholesterol, and swelling in the arms and legs. Patients may face a range of negative health outcomes, but the extent of these effects are unknown. In a study appearing in an upcoming issue of JASN, investigators evaluated kidney, cardiovascular, and mortality outcomes in adults with primary nephrotic syndrome.

Alan S. Go, MD (Kaiser Permanente Northern California Division of Research) and his colleagues examined data from a large, integrated healthcare delivery system to identify adults with primary nephrotic syndrome over a 16-year period. The researchers compared 907 patients' long-term kidney and cardiovascular outcomes with those from 89,593 adults without kidney disease.

Over a median follow-up of 4.5 years, adults with primary nephrotic syndrome had a 19.63-times higher risk of developing kidney failure, a 2.58-times higher risk of acute coronary syndrome, a 3.01-times higher risk of heart failure, a 1.80-times higher risk of ischemic stroke, a 2.56-times higher risk of venous thromboembolism, and a 1.34-times higher risk of death compared with controls.

Primary nephrotic syndrome can result from diseases called minimal change disease, focal segmental glomerulosclerosis, or membranous nephropathy. In this study, focal segmental glomerulosclerosis was associated with the highest risk of kidney failure, followed by membranous nephropathy and minimal change disease, but there were no significant differences in the risks of cardiovascular complications or death by cause of primary nephrotic syndrome.

"Our study highlights the high risk of kidney failure and the underappreciated excess risks of different arterial and venous cardiovascular complications linked to primary nephrotic syndrome due to focal segmental glomerulosclerosis, membranous nephropathy, or minimal change disease. Additional information is needed on the most effective ways to lower the risks of both kidney and cardiovascular complications in patients," said Dr. Go. "Our study also points to the need for patients with primary nephrotic syndrome to be identified as early as possible so that they can begin to implement lifestyle changes--such as moving toward a healthy diet, stopping smoking, getting more exercise--and to be evaluated for preventive therapies that can reduce their risk for both cardiovascular disease and kidney failure."

INFORMATION:

Study co-authors include Thida C. Tan, MPH; Glenn M. Chertow, MD, MPH; Juan D. Ordonez, MD, MPH; Dongjie Fan, MSPH; David Law, MD; Leonid Yankulin, MD; Janet M. Wojcicki, PhD, MPH; Sijie Zheng, MD, PhD; Kenneth K. Chen, MD; Farzien Khoshniat-Rad, BS; Jingrong Yang, MA; and Rishi V. Parikh, MPH.

Disclosures: The study was supported by a research grant from the Brin Wojcicki Foundation to Dr. Go through Kaiser Permanente Northern California. Dr. Chertow's relevant disclosures include a research grant from Amgen, and fees from Ardelyx, AstraZeneca, Baxter, Cricket, DiaMedica, Gilead Sciences, Reata, Sanifit, Vertex, Satellite Healthcare, Angion, Bayer, ReCor, and other disclosures from CloudCath, Durect, and Outset. The rest of the authors reported no financial disclosures.

The article, titled "Primary Nephrotic Syndrome and Risks of End-Stage Kidney Disease, Cardiovascular Events and Death: The Kaiser Permanente Nephrotic Syndrome Study," will appear online at http://jasn.asnjournals.org/ on June 18, 2021, doi: 10.1681/ASN.2020111583.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has more than 21,000 members representing 131 countries. For more information, visit http://www.asn-online.org.



ELSE PRESS RELEASES FROM THIS DATE:

Study examines symptoms before and after kidney transplantation

2021-06-19
Highlights In a study of patients waiting for a kidney transplant, those who experienced various symptoms had a higher risk of dying while on the waitlist. Symptoms tended to increase or remain unchanged between transplant evaluation and transplantation; however, at 3 months after transplantation, 9 of 11 symptoms lessened. Washington, DC (June 18, 2021) -- Investigators have examined how various symptoms experienced by individuals with kidney failure are impacted by kidney transplantation. The findings will appear in an upcoming issue of CJASN. People with kidney failure must often deal with numerous symptoms, such as fatigue, cramping, muscle soreness, numbness, dizziness, and loss of appetite. Although kidney transplantation ...

New research adds a wrinkle to our understanding of the origins of matter in the Milky Way

2021-06-19
New findings published this week in Physical Review Letters suggest that carbon, oxygen, and hydrogen cosmic rays travel through the galaxy toward Earth in a similar way, but, surprisingly, that iron arrives at Earth differently. Learning more about how cosmic rays move through the galaxy helps address a fundamental, lingering question in astrophysics: How is matter generated and distributed across the universe? "So what does this finding mean?" asks John Krizmanic, a senior scientist with UMBC's Center for Space Science and Technology (CSST). "These are indicators of something interesting happening. And what that ...

Stronger together: how protein filaments interact

2021-06-18
Just as the skeleton and muscles move the human body and hold its shape, all the cells of the body are stabilised and moved by a cellular skeleton. Unlike our skeleton, this cellular skeleton is a very dynamic structure, constantly changing and renewing itself. It consists of different types of protein filaments, which include intermediate filaments and microtubules. Now, a research team from the University of Göttingen is the first to succeed in observing a direct interaction between microtubules and intermediate filaments outside the cell, and also in quantitatively measuring this interaction. The results of the study were published in Nature Communications. Microtubules are dynamic filaments ...

New study uncovers details behind the body's response to stress

New study uncovers details behind the bodys response to stress
2021-06-18
Study Highlights New research reveals how key proteins interact to regulate the body's response to stress Targeting these proteins may help treat or prevent stress-related psychiatric disorders The biological mechanisms behind stress-related psychiatric conditions, including major depressive disorder and post-traumatic stress disorder (PTSD), are poorly understood. New research now details the interplay between proteins involved in controlling the body's stress response and points to potential therapeutic targets when this response goes awry. The study, which was conducted by an international team led by investigators at McLean Hospital, appears in ...

Carcinogen-exposed cells provide clues in fighting treatment-resistant cancers

Carcinogen-exposed cells provide clues in fighting treatment-resistant cancers
2021-06-18
BOSTON - Researchers from Massachusetts General Hospital (MGH) have discovered a biological mechanism that transforms cells exposed to carcinogens from environmental factors like smoking and ultraviolet light into immunogenic cells that can be harnessed therapeutically to fight treatment-resistant cancers. As reported in Science Advances, that mechanism involves spurring the release of small proteins known as chemokines which, in turn, recruit antitumor immune cells (CD8+ T cells) to the tumor site to block metastasis, potentially enhancing the effectiveness of a new generation of immunotherapies. "Immunotherapeutics ...

Memory helps us evaluate situations on the fly, not just recall the past

2021-06-18
CHICAGO --- Scientists have long known the brain's hippocampus is crucial for long-term memory. Now a new Northwestern Medicine study has found the hippocampus also plays a role in short-term memory and helps guide decision-making. The findings shed light on how the hippocampus contributes to memory and exploration, potentially leading to therapies that restore hippocampal function, which is impacted in memory-related aging and neurodegenerative diseases such as dementia, the study authors said. In the study, scientists monitored participants' brain activity and tracked their eye movements while looking at different complex pictures. The scientists discovered ...

Animals' ability to adapt their habitats key to survival amid climate change

Animals ability to adapt their habitats key to survival amid climate change
2021-06-18
Birds build nests to keep eggs and baby nestlings warm during cool weather, but also make adjustments in nest insulation in such a way the little ones can keep cool in very hot conditions. Mammals, such as rabbits or groundhogs, sleep or hibernate in underground burrows that provide stable, moderate temperatures and avoid above-ground conditions that often are far more extreme outside the burrow. Michael Dillon, an associate professor in the University of Wyoming Department of Zoology and Physiology, was part of a research group that examined animals' ability to respond to climate change likely depends on how well they modify their habitats, ...

Undiagnosed and untreated disease identified in rural South Africa

Undiagnosed and untreated disease identified in rural South Africa
2021-06-18
BIRMINGHAM, Ala. - A comprehensive health-screening program in rural northern KwaZulu-Natal, South Africa, has found a high burden of undiagnosed or poorly controlled non-communicable diseases, according to a study published in The Lancet Global Health. Researchers found that four out of five women over the age of 30 were living with a chronic health condition, and that the HIV-negative population and older people -- especially those over 50 -- bore the higher burden of undiagnosed or poorly controlled non-communicable diseases such as diabetes and hypertension. The study was co-led by Emily Wong, M.D., a resident faculty member at the Africa Health ...

Study reveals new therapeutic target for C. difficile infection

Study reveals new therapeutic target for C. difficile infection
2021-06-18
Irvine, CA - June 18, 2021 - A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries. Published today in Nature Communications, the study reveals the first 3D structure of the Clostridioides difficile toxin B (TcdB) in complex with chondroitin sulfate proteoglycan 4 (CSPG4), a human receptor. The study was co-led by senior author Rongsheng Jin, PhD, a professor in the Department of Physiology & Biophysics at the University of California, Irvine, School of Medicine, and Min Dong, PhD, an associate professor at Harvard Medical School. "TcdB is one of two homologous C. ...

New artificial heart shows promising results in 'auto-mode' -- initial clinical experience reported in ASAIO Journal

2021-06-18
June 18, 2021 - An experimental artificial heart includes an autoregulation control mechanism, or Auto-Mode, that can adjust to the changing needs of patients treated for end-stage heart failure. Outcomes in the first series of patients managed with the new heart replacement pump in Auto-Mode are presented in the ASAIO Journal, official journal of the American Society for Artificial Internal Organs. The journal is published in the Lippincott portfolio by Wolters Kluwer. The study reports on the response to "pressure sensor-based autoregulation of blood flow" in ten patients for up to two years after implantation of the Carmat Total Artificial ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] Study examines heart and kidney outcomes of adults with nephrotic syndrome
Patients face high risks of kidney failure and cardiovascular problems