Role of host genetics on gut microbiome is near-universal, but environmentally-dependent

A team led by researchers at Baylor College of Medicine found that a screening method known as untargeted metabolomics profiling can improve the diagnostic rate for inborn errors of metabolism, a group of rare genetic conditions, by about seven-fold when compared to the traditional metabolic screening approach. The study, published in JAMA Network Open, shows that untargeted metabolomics identifies many more disorders of greater variety as compared to traditional methods, including disorders for which there was not a clinically available biochemical test. The researchers hope that adoption of metabolomics to screen for inborn errors of metabolism will result in a more rapid, more efficient ...

The sharp eyes of an eagle, the extraordinary hearing of an owl - to successfully find food, the eyes and ears of birds have adapted optimally to their living conditions. Until now, the sense of smell has played a rather subordinate role. When meadows are freshly mowed, storks often appear there to search for snails and frogs. Researchers at the Max Planck Institute for Animal Behavior in Radolfzell and the Max Planck Institute for Chemistry in Mainz have now studied the birds' behavior and discovered that the storks are attracted by the smell of the mown grass. Only storks that were downwind and could thus perceive the smell reacted to the mowing. The scientists also sprayed a meadow with a spray of green leaf scents released during mowing. Storks appeared here as well. This ...

Recall a phone number or directions just recited and your brain will be actively communicating across many regions. It is thought that working memory relies on interactions between these regions, but how these brain areas interact and properly represent memory has remained a mystery. At Baylor College of Medicine, Dr. Nuo Li, assistant professor of neuroscience and a McNair Scholar, and his colleagues investigated the nature of the communication between brain regions involved in working memory and found evidence that a modular network organization is critical for ...

The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell. Researchers at Baylor College of Medicine and Rice University have found a new way to do just that through the creation of new genetic circuits called Equalizers. The findings, in the current edition of Nature Communications, show how researchers engineered these genetic circuits to buffer protein output from variations in the number of copies of the gene inside the cell, thereby helping to create consistent protein expression. This property is called "gene dosage compensation." The researchers use an analogy of heating ...

 Pure quantum systems can undergo phase transitions analogous to the classical phase transition between the liquid and gaseous states of water. At the quantum level, however, the particle spins in states that emerge from phase transitions display collective entangled behavior. This unexpected observation offers a new avenue for the production of materials with topological properties that are useful in spintronics applications and quantum computing.  The discovery was made by an international collaboration led by Julio Larrea, a professor at the University of São ...

DURHAM, N.C. -- You know your dog gets your gist when you point and say "go find the ball" and he scampers right to it. This knack for understanding human gestures may seem unremarkable, but it's a complex cognitive ability that is rare in the animal kingdom. Our closest relatives, the chimpanzees, can't do it. And the dogs' closest relative, the wolf, can't either, according to a new Duke University-led study published July 12 in the journal Current Biology. More than 14,000 years of hanging out with us has done a curious thing to the minds of dogs. They have what are known as "theory of mind" abilities, or mental skills allowing them to infer what humans are thinking and feeling in some situations. The study, a comparison of 44 ...

Astronomers have made the rare sighting of two stars spiralling to their doom by spotting the tell-tale signs of a teardrop-shaped star. The tragic shape is caused by a massive nearby white dwarf distorting the star with its intense gravity, which will also be the catalyst for an eventual supernova that will consume both. Found by an international team of astronomers and astrophysicists led by the University of Warwick, it is one of only very small number of star systems that has been discovered that will one day see a white dwarf star reignite its core. New research published by the team today (12 July) in Nature Astronomy confirms that the two stars are ...

Researchers from the Buck Institute and Stanford University have created an inflammatory clock of aging (iAge) which measures inflammatory load and predicts multi-morbidity, frailty, immune health, cardiovascular aging and is also associated with exceptional longevity in centenarians. Utilizing deep learning, a form of AI, in studies of the blood immunome of 1001 people, researchers also identified a modifiable chemokine associated with cardiac aging which can be used for early detection of age-related pathology and provides a target for interventions. Results are published in Nature Aging. "Standard immune metrics which can be used to identify individuals most at risk for developing single or even multiple chronic diseases ...

According to the study, Australia, Indonesia and the USA provide the largest carbon storage potential with their coastal ecosystems. The team also calculated which countries benefit most from the coastal CO2 uptake worldwide. The different ways in which countries are affected by climate change are quantified by using the so-called social costs of carbon. "If we take into account the differences in marginal climate damages that occur in each country, we find that Australia and Indonesia are clearly the largest donors in terms of globally avoided climate damages originating from coastal CO2 uptake, as they themselves derive comparatively little benefit ...

Many exoplanets have opaque atmospheres, obscured by clouds or hazes that make it hard for astronomers to characterize their chemical compositions. A new study shows that haze particles produced under different conditions have a wide range of properties that can determine how clear or hazy a planet's atmosphere is likely to be. Photochemical reactions in the atmospheres of temperate exoplanets lead to the formation of small organic haze particles. Large amounts of these photochemical hazes form in Earth's atmosphere every day, yet our planet has relatively clear skies. The reason has to do with how ...