PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Gene and cell therapies to combat pancreatic cancer

Gene and cell therapies to combat pancreatic cancer
2023-03-06
(Press-News.org) Pancreatic cancer is an incurable form of cancer, and gene therapies are currently in clinical testing to treat this deadly disease. A comprehensive review of the gene and cell biotherapies in development to combat pancreatic cancer is published in the peer-reviewed journal Human Gene Therapy. Click here to read the article now

The article titled “Pancreatic Cancer Cell and Gene Biotherapies: Past, Present and Future,” contributed by corresponding author Pierre Cordelier, from the University of Toulouse, and coauthors, describes the ongoing gene therapy clinical trials. In addition to gene therapies, the authors discuss vaccines, chimeric antigen receptor (CAR)-T cell therapy, suicide genes, and oncolytic viruses

“Breaking the code of pancreatic tumours rather than using brute force will help in defeating this currently incurable disease,” state the authors.

“There is no greater unmet medical need in the field right now than pancreatic cancer,” says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Chan Medical School. “This review provides a basis for understanding the lessons learned from past cell and gene therapies for pancreatic cancer, thereby informing the potential for future clinical progress.”

About the Journal
Human Gene Therapy, the Official Journal of the European Society of Gene and Cell Therapy and eight other international gene therapy societies, was the first peer-reviewed journal in the field and provides all-inclusive access to the critical pillars of human gene therapy: research, methods, and clinical applications. The Journal is led by Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Chan Medical School, and an esteemed international editorial board. Human Gene Therapy is available in print and online. Complete tables of contents and a sample issue are available on the Human Gene Therapy website.

About the Publisher
Mary Ann Liebert, Inc. is a global media company dedicated to creating, curating, and delivering impactful peer-reviewed research and authoritative content services to advance the fields of biotechnology and the life sciences, specialized clinical medicine, and public health and policy. For complete information, please visit the Mary Ann Liebert, Inc. website.

END

[Attachments] See images for this press release:
Gene and cell therapies to combat pancreatic cancer

ELSE PRESS RELEASES FROM THIS DATE:

Oncotarget | HALP score: Prognostic ability in cancers - a literature review

Oncotarget | HALP score: Prognostic ability in cancers - a literature review
2023-03-06
“In the last several years, the Hemoglobin, Albumin, Lymphocyte, Platelet Score (HALP) has emerged in the literature as a new prognostic biomarker [...]”  BUFFALO, NY- March 6, 2023 – A new review paper was published in Oncotarget's Volume 14 on February 25, 2023, entitled, “What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP’s prognostic ability in different cancer types.” Since its inception, the Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) Score has gained attention as a new prognostic biomarker to predict several clinical outcomes in a multitude ...

Nationwide study finds that women have greater risk of mortality than men after coronary artery bypass surgery

2023-03-06
Compared with men, women continue to have a roughly 30-40 percent higher risk of dying following coronary artery bypass surgery, according to a large study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center. The analysis showed that, without adjusting for differences in age and other health factors that influence risk, the female bypass patients had a 2.8 percent rate of death during or soon after surgery, compared with 1.7 percent for male patients, a nearly 50 percent difference that only dropped 10-20 percent after accounting for these factors. The study, which appears Mar. 1 in JAMA Surgery, was based on ...

Assessing the risk of excess folic acid intake

2023-03-06
It is well established that folic acid supplementation can significantly reduce the risk of birth defects, including neural tube defects like spina bifida, the most common birth defect of the central nervous system and the second most common of all structural birth defects. More than 80 nations, including the U.S. 25 years ago, have established mandated folic acid food fortification programs, which have been successful. “However, there is a lack of research on whether excessive folic acid intake has the potential ...

Geisinger study supports genetic testing for people with cerebral palsy

2023-03-06
DANVILLE, Pa. – A Geisinger meta-analysis of recent research on the genetics of cerebral palsy (CP) provides evidence that genetic testing should be offered as the standard of care for people with the disorder, similar to current recommendations for individuals with other neurodevelopmental disorders (NDD). The findings were published Tuesday in JAMA Pediatrics. Individual cases of CP—a condition that affects movement, balance and posture—have often been attributed to birth asphyxia, although recent studies show that asphyxia accounts for less than 10% of cases. A growing body of evidence suggests that a significant proportion of CP is caused by genetic changes, ...

New Geology articles published online ahead of print

2023-03-06
Boulder, Colo., USA: Article topics and locations include the Red Lake greenstone belt, Canada; Anak Krakatau volcano, Indonesia; martian soil; Glacial Lake Missoula, Montana, USA; and findings from IODP Expedition 385. These Geology articles are online at https://geology.geoscienceworld.org/content/early/recent . Crustal conductivity footprint of the orogenic gold district in the Red Lake greenstone belt, western Superior craton, Canada Ademola Q. Adetunji; Gaetan Launay; Ian J. Ferguson; Jack M. Simmons; Chong Ma ... A magnetotelluric (MT) study across the Red Lake greenstone belt of the ...

Mississippi River Delta study reveals which human actions contribute to land loss

Mississippi River Delta study reveals which human actions contribute to land loss
2023-03-06
BLOOMINGTON, Ind. — Research from scientists at Indiana University and Louisiana State University reveals new information about the role humans have played in large-scale land loss in the Mississippi River Delta — crucial information in determining solutions to the crisis. Published in Nature Sustainability, the study compares the impacts of different human actions on land loss and explains historical trends. Until now, scientists have been unsure about which human-related factors are the most consequential, and why ...

High-dose anticoagulation can reduce intubations and improve survival for hospitalized COVID-19 patients

High-dose anticoagulation can reduce intubations and improve survival for hospitalized COVID-19 patients
2023-03-06
High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation. These are the significant findings from the large-scale international “FREEDOM” trial, led by Valentin Fuster, MD, PhD, President of Mount Sinai Heart and Physician-in-Chief of The Mount Sinai Hospital, and General Director of the Spanish National Center for Cardiovascular Research (CNIC). The study results were announced Monday, March 6, ...

ASBMB offers feedback on NIH’s proposed grant review framework

2023-03-06
After soliciting feedback from its members, the American Society for Biochemistry and Molecular Biology sent nine recommendations to the National Institutes of Health last week related to proposed changes to the research grant application peer-review process. The society’s March 1 letter suggested: Validating the proposed framework with a pilot study Revamping the study section grant triage process Conducting outreach before and during implementation Using alternative criteria for certain types of projects Moving forward with simplifying scored criteria and administrative document review The NIH Office of Extramural Research ...

The marathon runners of the immune system

2023-03-06
When it comes to chronic infections and cancer, a particular type of immune cell plays a central role in our defenses. Researchers at the University of Basel have uncovered the key to the tenacity of these immune cells in coping with the marathon that is fighting a chronic infection. Their results lay the foundations for more effective therapies and vaccination strategies. Infected and abnormal cells have to go. And as quickly as possible, before any more damage is done. This is the task of what are known as cytotoxic T cells. ...

A wholly sustainable plastics economy is feasible

2023-03-06
Plastic is everywhere. Our society cannot do without it: plastics have numerous advantages, are extremely versatile, and are also cost effective. Today, plastics are mainly produced from crude oil. When the products reach the end of their life, they often end up in a waste incineration plant. The energy-intensive production of plastics and their incineration release large amounts of CO2 into the atmosphere, making plastic products a major contributor to climate change. One way out would be to rely on sustainable production methods, such as the circular economy, in which as much plastic as possible is recycled. Then the main raw material for ...

LAST 30 PRESS RELEASES:

Making lighter work of calculating fluid and heat flow

Normalizing blood sugar can halve heart attack risk

Lowering blood sugar cuts heart attack risk in people with prediabetes

Study links genetic variants to risk of blinding eye disease in premature infants

Non-opioid ‘pain sponge’ therapy halts cartilage degeneration and relieves chronic pain

AI can pick up cultural values by mimicking how kids learn

China’s ecological redlines offer fast track to 30 x 30 global conservation goal

Invisible indoor threats: emerging household contaminants and their growing risks to human health

Adding antibody treatment to chemo boosts outcomes for children with rare cancer

Germline pathogenic variants among women without a history of breast cancer

Tanning beds triple melanoma risk, potentially causing broad DNA damage

Unique bond identified as key to viral infection speed

Indoor tanning makes youthful skin much older on a genetic level

Mouse model sheds new light on the causes and potential solutions to human GI problems linked to muscular dystrophy

The Journal of Nuclear Medicine ahead-of-print tip sheet: December 12, 2025

Smarter tools for peering into the microscopic world

Applications open for funding to conduct research in the Kinsey Institute archives

Global measure underestimates the severity of food insecurity

Child survivors of critical illness are missing out on timely follow up care

Risk-based vs annual breast cancer screening / the WISDOM randomized clinical trial

University of Toronto launches Electric Vehicle Innovation Ontario to accelerate advanced EV technologies and build Canada’s innovation advantage

Early relapse predicts poor outcomes in aggressive blood cancer

American College of Lifestyle Medicine applauds two CMS models aligned with lifestyle medicine practice and reimbursement

Clinical trial finds cannabis use not a barrier to quitting nicotine vaping

Supplemental nutrition assistance program policies and food insecurity

Switching immune cells to “night mode” could limit damage after a heart attack, study suggests

URI-based Global RIghts Project report spotlights continued troubling trends in worldwide inhumane treatment

Neutrophils are less aggressive at night, explaining why nighttime heart attacks cause less damage than daytime events

Menopausal hormone therapy may not pose breast cancer risk for women with BRCA mutations

Mobile health tool may improve quality of life for adolescent and young adult breast cancer survivors

[Press-News.org] Gene and cell therapies to combat pancreatic cancer