PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Gene and cell therapies to combat pancreatic cancer

Gene and cell therapies to combat pancreatic cancer
2023-03-06
(Press-News.org) Pancreatic cancer is an incurable form of cancer, and gene therapies are currently in clinical testing to treat this deadly disease. A comprehensive review of the gene and cell biotherapies in development to combat pancreatic cancer is published in the peer-reviewed journal Human Gene Therapy. Click here to read the article now

The article titled “Pancreatic Cancer Cell and Gene Biotherapies: Past, Present and Future,” contributed by corresponding author Pierre Cordelier, from the University of Toulouse, and coauthors, describes the ongoing gene therapy clinical trials. In addition to gene therapies, the authors discuss vaccines, chimeric antigen receptor (CAR)-T cell therapy, suicide genes, and oncolytic viruses

“Breaking the code of pancreatic tumours rather than using brute force will help in defeating this currently incurable disease,” state the authors.

“There is no greater unmet medical need in the field right now than pancreatic cancer,” says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Chan Medical School. “This review provides a basis for understanding the lessons learned from past cell and gene therapies for pancreatic cancer, thereby informing the potential for future clinical progress.”

About the Journal
Human Gene Therapy, the Official Journal of the European Society of Gene and Cell Therapy and eight other international gene therapy societies, was the first peer-reviewed journal in the field and provides all-inclusive access to the critical pillars of human gene therapy: research, methods, and clinical applications. The Journal is led by Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Chan Medical School, and an esteemed international editorial board. Human Gene Therapy is available in print and online. Complete tables of contents and a sample issue are available on the Human Gene Therapy website.

About the Publisher
Mary Ann Liebert, Inc. is a global media company dedicated to creating, curating, and delivering impactful peer-reviewed research and authoritative content services to advance the fields of biotechnology and the life sciences, specialized clinical medicine, and public health and policy. For complete information, please visit the Mary Ann Liebert, Inc. website.

END

[Attachments] See images for this press release:
Gene and cell therapies to combat pancreatic cancer

ELSE PRESS RELEASES FROM THIS DATE:

Oncotarget | HALP score: Prognostic ability in cancers - a literature review

Oncotarget | HALP score: Prognostic ability in cancers - a literature review
2023-03-06
“In the last several years, the Hemoglobin, Albumin, Lymphocyte, Platelet Score (HALP) has emerged in the literature as a new prognostic biomarker [...]”  BUFFALO, NY- March 6, 2023 – A new review paper was published in Oncotarget's Volume 14 on February 25, 2023, entitled, “What is hemoglobin, albumin, lymphocyte, platelet (HALP) score? A comprehensive literature review of HALP’s prognostic ability in different cancer types.” Since its inception, the Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) Score has gained attention as a new prognostic biomarker to predict several clinical outcomes in a multitude ...

Nationwide study finds that women have greater risk of mortality than men after coronary artery bypass surgery

2023-03-06
Compared with men, women continue to have a roughly 30-40 percent higher risk of dying following coronary artery bypass surgery, according to a large study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center. The analysis showed that, without adjusting for differences in age and other health factors that influence risk, the female bypass patients had a 2.8 percent rate of death during or soon after surgery, compared with 1.7 percent for male patients, a nearly 50 percent difference that only dropped 10-20 percent after accounting for these factors. The study, which appears Mar. 1 in JAMA Surgery, was based on ...

Assessing the risk of excess folic acid intake

2023-03-06
It is well established that folic acid supplementation can significantly reduce the risk of birth defects, including neural tube defects like spina bifida, the most common birth defect of the central nervous system and the second most common of all structural birth defects. More than 80 nations, including the U.S. 25 years ago, have established mandated folic acid food fortification programs, which have been successful. “However, there is a lack of research on whether excessive folic acid intake has the potential ...

Geisinger study supports genetic testing for people with cerebral palsy

2023-03-06
DANVILLE, Pa. – A Geisinger meta-analysis of recent research on the genetics of cerebral palsy (CP) provides evidence that genetic testing should be offered as the standard of care for people with the disorder, similar to current recommendations for individuals with other neurodevelopmental disorders (NDD). The findings were published Tuesday in JAMA Pediatrics. Individual cases of CP—a condition that affects movement, balance and posture—have often been attributed to birth asphyxia, although recent studies show that asphyxia accounts for less than 10% of cases. A growing body of evidence suggests that a significant proportion of CP is caused by genetic changes, ...

New Geology articles published online ahead of print

2023-03-06
Boulder, Colo., USA: Article topics and locations include the Red Lake greenstone belt, Canada; Anak Krakatau volcano, Indonesia; martian soil; Glacial Lake Missoula, Montana, USA; and findings from IODP Expedition 385. These Geology articles are online at https://geology.geoscienceworld.org/content/early/recent . Crustal conductivity footprint of the orogenic gold district in the Red Lake greenstone belt, western Superior craton, Canada Ademola Q. Adetunji; Gaetan Launay; Ian J. Ferguson; Jack M. Simmons; Chong Ma ... A magnetotelluric (MT) study across the Red Lake greenstone belt of the ...

Mississippi River Delta study reveals which human actions contribute to land loss

Mississippi River Delta study reveals which human actions contribute to land loss
2023-03-06
BLOOMINGTON, Ind. — Research from scientists at Indiana University and Louisiana State University reveals new information about the role humans have played in large-scale land loss in the Mississippi River Delta — crucial information in determining solutions to the crisis. Published in Nature Sustainability, the study compares the impacts of different human actions on land loss and explains historical trends. Until now, scientists have been unsure about which human-related factors are the most consequential, and why ...

High-dose anticoagulation can reduce intubations and improve survival for hospitalized COVID-19 patients

High-dose anticoagulation can reduce intubations and improve survival for hospitalized COVID-19 patients
2023-03-06
High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation. These are the significant findings from the large-scale international “FREEDOM” trial, led by Valentin Fuster, MD, PhD, President of Mount Sinai Heart and Physician-in-Chief of The Mount Sinai Hospital, and General Director of the Spanish National Center for Cardiovascular Research (CNIC). The study results were announced Monday, March 6, ...

ASBMB offers feedback on NIH’s proposed grant review framework

2023-03-06
After soliciting feedback from its members, the American Society for Biochemistry and Molecular Biology sent nine recommendations to the National Institutes of Health last week related to proposed changes to the research grant application peer-review process. The society’s March 1 letter suggested: Validating the proposed framework with a pilot study Revamping the study section grant triage process Conducting outreach before and during implementation Using alternative criteria for certain types of projects Moving forward with simplifying scored criteria and administrative document review The NIH Office of Extramural Research ...

The marathon runners of the immune system

2023-03-06
When it comes to chronic infections and cancer, a particular type of immune cell plays a central role in our defenses. Researchers at the University of Basel have uncovered the key to the tenacity of these immune cells in coping with the marathon that is fighting a chronic infection. Their results lay the foundations for more effective therapies and vaccination strategies. Infected and abnormal cells have to go. And as quickly as possible, before any more damage is done. This is the task of what are known as cytotoxic T cells. ...

A wholly sustainable plastics economy is feasible

2023-03-06
Plastic is everywhere. Our society cannot do without it: plastics have numerous advantages, are extremely versatile, and are also cost effective. Today, plastics are mainly produced from crude oil. When the products reach the end of their life, they often end up in a waste incineration plant. The energy-intensive production of plastics and their incineration release large amounts of CO2 into the atmosphere, making plastic products a major contributor to climate change. One way out would be to rely on sustainable production methods, such as the circular economy, in which as much plastic as possible is recycled. Then the main raw material for ...

LAST 30 PRESS RELEASES:

New Study identifies early signs of valve failure one year after TAVI, raising durability concerns in younger patients

Untangling glucose traffic jams in Type 2 diabetes

University of Houston professor creates new drug delivery system to tackle lupus

Community-based approach boosts family engagement in ADHD care

Identifying a compass in the human brain

How AI support can go wrong in safety-critical settings

American Geriatrics Society unveils updated alternatives to potentially harmful medications for older adults

Conflicts of interest on CDC vaccine panel were at historic lows before RFK Jr. dismissal

Stapokibart for severe uncontrolled chronic rhinosinusitis with nasal polyps

Brain abnormalities seen in children exposed prenatally to the pesticide chlorpyrifos

Self-reported hearing aid use and risk of incident dementia

Over-the-counter oral contraceptive use and initiation of contraception

Over-the-counter pill boosts access to contraception, OHSU study finds

New research ferments the perfect recipe for fine chocolate flavor

SwRI study supports theory that asteroids Bennu and Ryugu are part of the Polana family

Seabirds only poop while flying

SwRI develops orbital debris detection system for spacecraft

Exploration and dispersal are key traits involved in a rapid range expansion

New study reveals the gene responsible for diverse color patterns in African violet flower

A novel technology to control crystallinity of pore walls

Researchers uncover potential mechanism driving treatment resistance in common breast cancer

Colorado State University shutters animal study after pressure from national research ethics group

Texas study reveals heat waves can cause more polluted air

A potential ‘green’ alternative to formaldehyde and PFAS in fabric finishing

Small molecule could alleviate acetaminophen-induced liver injury

Nuclear waste could be a source of fuel in future reactors

New study reveals preventing an hour of intense pain in chickens costs less than a hundredth of a cent

An alternative to LASIK — without the lasers

Ultrasound could deliver drugs with fewer side effects

New study reveals body’s cells change shape to deal with wounds

[Press-News.org] Gene and cell therapies to combat pancreatic cancer