(Press-News.org) New Haven, Conn. — Yale School of Medicine announces the initiation of a novel, randomized trial that will test whether receiving PAXLOVIDTM (nirmatrelvir tablets; ritonavir tablets) for 15 days can improve the health of highly symptomatic adults with Long COVID.
The trial, led by Yale School of Medicine Professors Harlan Krumholz and Akiko Iwasaki, has a decentralized design, meaning that participants do not have to travel to study sites. It also uses a novel, participant-centric, digital approach to data collection.
Long COVID, also known as post-acute sequelae SARS-CoV-2 infection (PASC), is estimated to affect millions of people worldwide. For some people, Long COVID has severely impaired their quality of life and even caused death. To date, there are no approved treatments for Long COVID.
The new trial will enroll 100 research participants and investigate the overall effect of PAXLOVID, while also seeking clues for which people might respond best to the drug and why. Importantly, the study will assess changes in how people feel and how their immune system functions in response to the drug. The study will enroll previously healthy people with fair to poor health as a result of Long COVID. Participants will not have any contraindications to PAXLOVID or recent treatment with the drug.
The decentralized design seeks to make participation easier and avoid the need for travel to a study site. The study uses mobile devices for study surveys, the Hugo Health digital health platform to engage participants and connect clinical data, and a strategy to collect biospecimens at a convenient place for participants. The study will be initially open to people in Connecticut, New York, and Florida.
The Yale Center for Infection and Immunity and the Yale Center for Outcomes Research and Evaluation at Yale School of Medicine are collaborating on the study. Pfizer is funding the study and has provided scientific support in the clinical trial design and protocol development. For more information, see the listing on clinicaltrials.gov (NCT05668091).
The research study is enrolling through the Hugo Health Kindred Long COVID community, which is an open and growing community for people interested in research into Long COVID. The community is oriented toward a partnership model of research and data sharing.
Dr. Krumholz is a co-founder of Hugo Health.
For any questions about the study, contact YalePaxStudy@yale.edu.
END
New Yale study evaluates PAXLOVID’s use in Long COVID recovery
2023-03-21
ELSE PRESS RELEASES FROM THIS DATE:
ESMT Berlin: New book on how industrial companies can survive deglobalization
2023-03-21
Deglobalization and the unpredictability of global business have led technology-based industries to review their overall strategies. Current geopolitical changes – the war in Ukraine, effects of the pandemic, and greenhouse gas emission targets – revived discussions about the value of globalization. However, international trade of goods and services has been slowing down significantly since 2011, with increasing nationalism being a factor. Additionally, lower salary differentials between developed and emerging economies have reduced overseas product shipments – which are increasingly criticized regarding environmental impact. So, how ...
Scientists find a common thread linking subatomic color glass condensate and massive black holes
2023-03-21
The Science
Physicists have discovered a remarkable correspondence between dense states of gluons—the gluelike carriers of the strong nuclear force within atomic nuclei—and enormous black holes in the cosmos. The dense walls of gluons, known as a color glass condensate (CGC), are generated in collisions of atomic nuclei. This CGC measures a mere 10-19 kilometers across—less than a billionth of a kilometer. Black holes, in contrast, span billions of kilometers across. The new work shows that both systems are made of densely packed, self-interacting force carrier particles. In CGC, those particles are ...
Vocal tract size, shape dictate speech sounds
2023-03-21
WASHINGTON, March 21, 2023 – Only humans have the ability to use speech. Remarkably, this communication is understandable across accent, social background, and anatomy despite a wide variety of ways to produce the necessary sounds.
In JASA, published on behalf of the Acoustical Society of America by AIP Publishing, researchers from University Hospital and Medical Faculty of the RWTH Aachen University explored how anatomical variations in a speaker’s vocal tract affect speech production.
The vocal tract looks like an air duct, starting at the vocal cords and moving vertically through the larynx before bending at the back of the mouth and running ...
Healthy men who have vaginal sex have a distinct urethral microbiome
2023-03-21
Contrary to common beliefs, your urine is not germ free. In fact, a new study shows that the urethra of healthy men is teeming with microbial life and that a specific activity—vaginal sex—can shape its composition. The research, published March 24 in the journal Cell Reports Medicine, provides a healthy baseline for clinicians and scientists to contrast between healthy and diseased states of the urethra, an entrance to the urinary and reproductive systems.
“We know where bugs in the gut come from; they primarily come from our surroundings ...
A recipe for 3D-printing food
2023-03-21
WASHINGTON, March 21, 2023 – 3D-printing food could address global challenges in food supply and nutrition. But there are hurdles involved in adapting additive manufacturing to produce edible materials.
In Physics of Fluids, from AIP Publishing, University of Ottawa researchers Ezgi Pulatsu and Chibuike Udenigwe identify a range of factors that affect the print quality and shape complexity of food created with additive manufacturing. Accounting for these features can increase food quality, improve control, and speed up printing.
Additive manufacturing of food involves designing (3D shapes and their geometric codes), ...
Cascading failures in urban traffic systems tied to hidden bottlenecks
2023-03-21
WASHINGTON, March 21, 2023 – Transportation systems in urban settings are vulnerable to a variety of factors including weather, traffic congestion, and special events. Bottlenecks, in particular, can cause major problems and lead to cascading failure of the entire system.
Scientists from Fudan University and Shanghai University of Electric Power in China developed a modeling technique to study urban traffic flows and verified it with real-world data from Shanghai. They describe their approach in Chaos, by AIP Publishing, and show that their model can be used to find previously unknown bottlenecks that could ...
Pew funds 7 researchers to advance ocean conservation
2023-03-21
PHILADELPHIA—Today, The Pew Charitable Trusts announced the seven recipients of the 2023 Pew Fellowship in Marine Conservation. The researchers—from Australia, Brazil, Cape Verde, China, the United Kingdom, and the United States—join a network of 202 Pew marine fellows from 42 countries.
“Pew has long supported experts whose considerable talents and solution-oriented approaches help address complex challenges in the marine environment,” said Susan K. Urahn, Pew’s president ...
CHOP researchers find strong adolescent-parent relationships lead to better long-term health outcomes in young adults
2023-03-21
Philadelphia, March 21, 2023 – Researchers from Children’s Hospital of Philadelphia (CHOP) have found that adolescents who report strong relationships with their parents have better long-term health outcomes. Study findings, published today in JAMA Network Open, suggest that investments in improving parent–adolescent relationships could help improve general health, mental health and sexual, health while also reducing substance use in young adulthood.
Prior research shows that positive ...
Association between rates of down syndrome diagnosis in states with vs without 20-week abortion bans
2023-03-21
About The Study: In this study of 31 million births in the United States from 2011 to 2018, neonatal Down syndrome diagnoses increased more in states that enacted 20-week abortion bans compared with states that did not enact bans. Because these abortion bans were enacted throughout the study period and are known to inhibit choice in patient decision-making, it is possible that the difference in the rates of diagnosis is associated with these policies.
Authors: Sarina R. Chaiken, B.A., and Aaron B. Caughey, M.D., Ph.D., of the Oregon Health & Science University in Portland, is the corresponding author.
To ...
Patient and hospital characteristics associated with postpartum emergency department care
2023-03-21
About The Study: This study including 608,000 obstetric discharges found that Black and Hispanic patients experienced higher adjusted odds of postpartum emergency department visits across all hospital types, particularly at safety net hospitals and those disproportionately serving racial and ethnic minority populations. These findings support the urgent need to mitigate structural racism underlying maternal health disparities.
Authors: Michelle P. Lin, M.D., M.P.H., M.S., of Stanford ...