(Press-News.org) In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab—an antibody that targets a protein expressed on certain immune cells—was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus.
In the analysis, which is published in Arthritis & Rheumatology, compared with standard-of-care treatment alone, the addition of obinutuzumab to lupus nephritis treatment reduced the risk of developing a composite outcome of death, fall in kidney function, or treatment failure by 60%. Adding obinutuzumab also reduced the risk of lupus nephritis relapses by 57% and significantly decreased the rate of decline in kidney function over the 2 years of the trial.
Overall, 38% of obinutuzumab-treated patients compared with 16% of placebo-treated patients achieved a complete remission of lupus nephritis by week 76, with the need for fewer glucocorticoids.
“These data are really important because the ultimate goal of lupus nephritis therapy is to preserve kidney survival so patients never have to face the need for dialysis or transplantation because their kidneys failed,” said corresponding author Brad Rovin, MD, of Ohio State University Wexner Medical Center. “The addition of obinutuzumab to standard lupus nephritis therapy may increase the likelihood of achieving this goal.”
URL upon publication: https://onlinelibrary.wiley.com/doi/10.1002/art.42734
Additional Information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com.
About the Journal
Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed publication for scientists and clinicians interested in the natural history, pathophysiology, treatment, and outcome of the rheumatic diseases. The journal publishes the highest quality basic and clinical research related to the rheumatic diseases, encompassing a wide range of areas of investigative activity.
About Wiley
Wiley is a knowledge company and a global leader in research, publishing, and knowledge solutions. Dedicated to the creation and application of knowledge, Wiley serves the world’s researchers, learners, innovators, and leaders, helping them achieve their goals and solve the world's most important challenges. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, Twitter, LinkedIn and Instagram.
END
Trial generates promising results for obinutuzumab in patients with lupus nephritis
2023-11-10
ELSE PRESS RELEASES FROM THIS DATE:
Leading cardiologists reveal new heart disease risk calculator
2023-11-10
Statement Highlights:
The new American Heart Association PREVENTTM risk calculator estimates the 10- and 30-year risk of total cardiovascular disease for people aged 30 years and older.
The calculator estimates the risk of heart attack, stroke and — for the first time — heart failure. The equations are sex-specific and race-free, acknowledging that race is not a biological factor, and can include an index of social determinants of health.
This is the first risk calculator that combines measures of cardiovascular, kidney ...
Physical fitness since childhood predicts cerebellar volume in adolescence
2023-11-10
Physical fitness since childhood is associated with cerebellar grey matter volume in adolescents. According to a recent study conducted at the University of Jyväskylä and the University of Eastern Finland, those who were stronger, faster and more agile, in other words, had better neuromuscular fitness since childhood, had larger Crus I grey matter volume in adolescence.
Despite the importance of the developing cerebellum on cognition and learning, the associations between physical fitness and cerebellar volume in adolescents have remained unclear. This study examined the associations ...
Scientists found hundreds of toxic chemicals in recycled plastics
2023-11-10
When scientists examined pellets from recycled plastic collected in 13 countries they found hundreds of toxic chemicals, including pesticides and pharmaceuticals.
The results are published in a study led by scientists at the University of Gothenburg.
Because of this, the scientists judge recycled plastics unfit for most purposes and a hinder in the attempts to create a circular economy.
Delegates, scientists and health and environmental advocates from around the world are traveling to Nairobi, Kenya for next week’s meeting of the third session of the Plastics Treaty Intergovernmental Negotiating ...
New cooling ceramic can enhance energy efficiency for the construction sector and help combat global warming—City University of Hong Kong research
2023-11-10
A significant breakthrough in developing a passive radiative cooling (PRC) material has been announced by researchers at City University of Hong Kong (CityU). The findings have just been published in the prestigious scientific journal Science titled “Hierarchically structured passive radiative cooling ceramic with high solar reflectivity.”
The material, known as cooling ceramic, has achieved high-performance optical properties for energy-free and refrigerant-free cooling generation. Its cost-effectiveness, durability and versatility make it highly suitable for commercialisation in numerous applications, particularly in ...
CNIC scientists identify the crucial role of the protein neuregulin-1 in heart development
2023-11-10
In a study published in the journal Circulation Research, researchers at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Dr. José Luis de la Pompa reveal the essential role of the protein neuregulin-1 (Nrg1) in the intricate transformation of the heart from its delicate primordial structure into a powerful pumping organ.
The findings not only highlight the pathways through which the human heart forms, but also suggest important directions for future medical advances. Commenting on the study, Dr. de la Pompa, head of the ...
Bullying victims who perceive they’re targeted due to social characteristics feel the effects worse, new research suggests
2023-11-10
Students who feel they have been victimized because of social characteristics such as their ethnicity or their sexuality are at additional risk of trauma, a new national US study has revealed.
Published in the peer-reviewed Journal of School Violence, the research, of more than 2,200 young victims of bullying, found students reported that their physical health; self-esteem; social relationships, and schoolwork suffered more if they felt bias was behind the perpetrators’ actions.
This was particularly ...
Any activity is better for your heart than sitting – even sleeping
2023-11-10
The study, supported by the British Heart Foundation (BHF) and published in the European Heart Journal, is the first to assess how different movement patterns throughout the 24-hour day are linked to heart health. It is the first evidence to emerge from the international Prospective Physical Activity, Sitting and Sleep (ProPASS) consortium.
Cardiovascular disease, which refers to all diseases of the heart and circulation, is the number one cause of mortality globally. In 2021, it was responsible for one in three ...
Health: Lack of friend or family visits is associated with increased risk of dying
2023-11-10
Never being visited by friends or family is associated with an increased risk of dying, according to a study published in BMC Medicine. The authors suggest that their findings could be used to help identify patients at a higher risk of dying due to social factors, and to develop more effective interventions to combat the increased risk of death associated with social isolation.
Although previous research has identified associations between deaths due to any causes and both a ‘sense of loneliness’ and living alone, the combined impacts of different types of social interaction ...
Aid agencies are failing patients with breast cancer in war zones meaning more will develop advanced disease
2023-11-10
Lisbon, Portugal: Patients with breast cancer in conflict zones around the world are being “massively under-served” by governments, UN aid agencies and other non-governmental organisations (NGOs), Professor Richard Sullivan told the Advanced Breast Cancer Seventh International Consensus Conference (ABC 7). [1]
Among people fleeing conflict zones, either displaced within their own country or across borders to other countries, patients with breast cancer are the “single largest group of cancer patients that present to UN agencies and international NGOs,” said Prof. Sullivan, who is director of the Institute of Cancer Policy and co-director of the Centre for ...
Is the US reporting system for vaccine safety broken?
2023-11-10
Is the US reporting system for vaccine safety broken?
Investigation raises concerns that the system is not operating as intended and signals are being missed
A US reporting system designed to detect potential safety issues with vaccines is supposed to be user-friendly, responsive, and transparent. But an investigation published by The BMJ today finds it’s not meeting its own standards.
The Vaccine Adverse Event Reporting System (VAERS), co-managed by the US Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA), collects reports of symptoms, ...