New resource for selecting best treatment path for young children with cancerous tumors published by NCCN
New NCCN Guidelines for Neuroblastoma address the importance and impact of risk stratification for treating one of the more common types of pediatric solid tumors; includes vanguard treatment recommendations involving multimodality treatment for high-risk
2024-02-07
(Press-News.org) PLYMOUTH MEETING, PA [February 7, 2024] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers—today published its first ever set of treatment recommendations pertaining to neuroblastoma. Neuroblastoma is a type of solid tumor cancer that typically occurs in early childhood, with the majority diagnosed before age five.[1] Neuroblastoma is the most common type of solid tumor (outside of brain tumors) in children, with more than 700 cases diagnosed in the United States every year.[2] Research innovations have led to survival rates that are better than 90% for patients with low- and intermediate-risk neuroblastoma and around 50% for those with high-risk disease.[3] Improving outcomes for patients with high-risk neuroblastoma and reducing long-term treatment effects for all patients remain areas of active research.
“Neuroblastoma is a biologically and clinically heterogeneous cancer, which creates many challenges for those treating patients with this disease,” said Rochelle Bagatell, MD, Professor of Pediatrics and Solid Tumor Section Chief at Children's Hospital of Philadelphia, and Chair of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Panel for Neuroblastoma. “The NCCN Guidelines were designed to assist clinicians caring for children with neuroblastoma by providing key information regarding risk stratification and by summarizing the data that have led to the current approaches to therapy. As new clinical trial results become available and as therapies evolve, we will continue to support providers by updating the guidelines over time.”
Dr. Bagatell will be presenting an on-demand online session on the latest updates for neuroblastoma in the new NCCN Guidelines as part of the NCCN 2024 Annual Conference on April 5 – 7. Visit NCCN.org/conference to learn more and register.
“These new NCCN Guidelines for Neuroblastoma are the perfect platform for sharing how to think about this complicated disease and determine which categories of treatment should be considered for each individual patient,” explained Julie R. Park, MD, Chair, Department of Oncology, St. Jude Children's Research Hospital, Vice-Chair, NCCN Guidelines Panel for Neuroblastoma. “The guidelines break down how to incorporate the multi-disciplinary care that is needed, such as surgery or radiation, plus specific options for chemotherapy regimens.”
There are now 87 different NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), covering nearly every type of cancer, plus screening, prevention, and supportive care. The NCCN Guidelines® for Neuroblastoma are the 6th to focus specifically on treating pediatric cancer.
The NCCN Guidelines have a long history of providing treatment guidance that correlates with improved outcomes across numerous cancer types. The recommendations are determined by a multidisciplinary panel of experts from NCCN’s Member Institutions using the best available evidence and are updated at least once every year. By utilizing specialists with diverse areas of expertise and geographic locations, the panels are able to make sure the recommendations are thorough, representative, and understandable—particularly for clinicians who may not see patients with neuroblastoma very often. The NCCN Guidelines are intended as a resource for care providers and coverage determinations throughout the U.S. and around the world.
“We are particularly concerned with figuring out how to minimize treatment where possible,” said Dr. Park. “We wanted to make it easy for providers to quickly recognize which patients can have positive outcomes while experiencing less toxicity. That means including a lot of information on diagnosis and delving into analysis for molecular drivers and aspects of immunotherapy.”
Some of the common late effects from neuroblastoma treatment can include fertility issues, growth impairment, hearing trouble, and organ dysfunction.[4] NCCN also publishes NCCN Guidelines for Adolescent and Young Adult Oncology, which provide treatment advice geared toward younger populations across all cancer types. There are separate NCCN Guidelines for Survivorship that include additional information on mitigating the long-term impact of treatment.
All NCCN Guidelines are available with a free account at NCCN.org or via the Virtual Library of NCCN Guidelines® App.
# # #
About the National Comprehensive Cancer Network
The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, equitable, and accessible cancer care so all patients can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) provide transparent, evidence-based, expert consensus recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation®. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit NCCN.org for more information.
[1] Neuroblastoma Treatment (PDQ®): Health Professional Version. 2023 Aug 22. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002. 2023. Available at: https://www.ncbi.nlm.nih.gov/books/NBK65747/
[2] About Neuroblastoma. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8758.00.pdf.
[3] Neuroblastoma Early Detection, Diagnosis, and Staging. 2021. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8760.00.pdf
[4] Friedman DN, Henderson TO. Late Effects and Survivorship Issues in Patients with Neuroblastoma. Children (Basel) 2018;5.
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2024-02-07
Highlights:
Alterations in gut microbiota may influence immune system changes during pregnancy.
However, the connection isn’t well known.
Researchers in China analyzed gut microbiota, metabolites and cytokines in healthy pregnant and non-pregnant young women.
The new study identifies numerous pathways by which the gut microbiome may change the immune system.
Washington, D.C.—During pregnancy, a woman’s immune system changes dramatically but researchers don’t yet understand all the underlying mechanisms. A new study shows how the gut microbiota may play a role.
In a paper published this week in mSystems, researchers in China report that during pregnancy, ...
2024-02-07
Highlights:
Wastewater, even when treated, can deliver antimicrobial resistance genes to rivers.
Further research is needed on if rivers function as a protective barrier.
Researchers subjected biofilms from pristine rivers to wastewater.
Antibiotic resistant bacteria from wastewater successfully integrated at first, but in the warmest water were edged out by naturally occurring microbes.
The study suggests that temperature can influence the microbial competition in rivers.
Washington, D.C.—Antimicrobial resistant genes (ARGs) from wastewater can end up in natural biofilms in rivers, but they may not stick around very long. This week in mSphere, ...
2024-02-07
Accelerating Innovation in Medicine - Health Initiative (AIM-HI) is proud to celebrate a significant milestone in the journey of one of its esteemed portfolio companies, Yiviva. A clinical-stage platform biotechnology company, Yiviva has entered into a Memorandum of Understanding (MOU) with AstraZeneca China, a multinational biopharmaceutical leader.
AIM-HI exists to support bold new ideas in treating and preventing cancer. So when Yale Professor Yung-Chi Cheng approached us years ago about mining ancient Chinese herbs for modern therapies, we took notice. Other investors ...
2024-02-07
DALLAS, Feb. 7, 2024 — Research teams from Northwestern University Feinberg School of Medicine, New York University and Duke University will work together to assess the accuracy of the American Heart Association’s new PREVENTTM risk calculator with funding from the Association’s De-biasing Clinical Care Algorithms project.
The American Heart Association, celebrating 100 years of service in 2024, is the single largest non-government supporter of heart and brain health research in the U.S. The de-biasing project is funded by a grant from the Doris Duke Foundation to study the role of race and ethnicity in clinical equations and their ...
2024-02-07
Geographic sorting along ideological lines is on the rise. Counties and regions of the United States differ in political ideology. But do they differ in personality as well? Further, are people who ‘fit’ their communities healthier, happier, or more highly achieving than those who do not?
In the context of these growing divisions and to address this question, a study by Florida Atlantic University’s Kevin Lanning, Ph.D., senior author and a professor of psychology and data science in the Harriet L. Wilkes Honors College on FAU’s John D. MacArthur Campus in Jupiter, and ...
2024-02-07
One of the most important components of satellites that enable telecommunication is the waveguide, which is a metal tube for guiding radio waves. It is also one of the heaviest payloads satellites carry into orbit. As with all space technology, reducing weight means reducing the amount of expensive and greenhouse gas-producing fuel it takes to launch a rocket, or increasing the number of devices carried by the same rocket to space. Researchers from Drexel University and the University of British Columbia are trying to lighten the load by creating and testing a waveguide made ...
2024-02-07
More than half of Americans do not currently meet the daily recommendation of 5–7 ounce equivalents^ of nuts and seeds per week.1
One possible contributor to such low intakes of tree nuts could be a fear that the calories or fat composition of tree nuts leads to weight gain.
For example, past studies suggest that up to 87% of Americans think eating nuts can lead to weight gain due to their dietary fat content2 despite scientists confirming that eating nuts every day, including pistachios,3 can be an achievable and simple strategy to ...
2024-02-07
A more accurate way of identifying underground nuclear tests, including those conducted in secret, has been developed by researchers at The Australian National University (ANU).
The new method could help international observers better identify tests carried out by countries or actors known to possess nuclear weapons, as well as providing new information about those suspected of being armed.
According to lead author Dr Mark Hoggard, in the aftermath of the Cuban Missile Crisis and Partial Test Ban Treaty in the 1960s, testing of nuclear ...
2024-02-07
DALLAS, Feb. 6, 2024 — Five promising scientific researchers will advance their work to better understand and treat the most common birth defect in the U.S., congenital heart defects (CHDs), thanks to joint financial support from the American Heart Association and The Children’s Heart Foundation's Congenital Heart Defect Research Awards program.
To date, the American Heart Association, celebrating 100 years of lifesaving service and devoted to a world of healthier lives for all, and The Children’s Heart Foundation, dedicated to funding congenital heart defect research, have ...
2024-02-07
HOUSTON – (Feb. 7, 2024) – Artificial intelligence is good at many tasks involving data in the form of text, audio and images, including face recognition and text summarization.
“AI is an amazing tool and has been extended over less conventional domains, such as climate data defined on spheres (representing the Earth) and traffic data defined on road networks,” said Santiago Segarra, assistant professor of electrical and computer engineering and statistics.
With his five-year, $599,138 CAREER Award from the National Science Foundation, Segarra intends to study the use of graphs to represent these ...
LAST 30 PRESS RELEASES:
[Press-News.org] New resource for selecting best treatment path for young children with cancerous tumors published by NCCN
New NCCN Guidelines for Neuroblastoma address the importance and impact of risk stratification for treating one of the more common types of pediatric solid tumors; includes vanguard treatment recommendations involving multimodality treatment for high-risk
