(Press-News.org)
“Our data demonstrated, for the first time, the antioxidant activity of geraniol and its function to attenuate brain hippocampus injury induced in vivo by D-galactose.”
BUFFALO, NY- April 10, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, “Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model.”
D-galactose (D-gal) administration was proven to induce cognitive impairment and aging in rodents’ models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. GNL reduces inflammation by changing important signaling pathways and cytokines, and thus it is plausible to be used as a medicine for treating disorders linked to inflammation. In this new study, researchers Peramaiyan Rajendran, Fatma J. Al-Saeedi, Rebai Ben Ammar, Basem M. Abdallah, Enas M. Ali, Najla Khaled Al Abdulsalam, Sujatha Tejavat, Duaa Althumairy, Vishnu Priya Veeraraghavan, Sarah Abdulaziz Alamer, Gamal M. Bekhet, and Emad A. Ahmed from King Faisal University, Kuwait University, Center of Biotechnology of Borj-Cedria, Saveetha University, Alexandria University, and Assiut University examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuroinflammation-mediated memory loss in mice.
“Life expectancy in the 21st century is rising, resulting in more age-related illnesses, such as memory impairment and Alzheimer’s disease. In this study, GNL was studied for its protective effect on D-gal-induced aging in mice.”
The study was conducted using six groups of mice (6 mice per group). The first group received normal saline, then D-gal (150 mg/wt) dissolved in normal saline solution (0.9%, w/v) was given orally for 9 weeks to the second group. In the III group, from the second week until the 10th week, mice were treated orally (without anesthesia) with D-gal (150 mg/kg body wt) and GNL weekly twice (40 mg/kg body wt) four hours later. Mice in Group IV were treated with GNL from the second week up until the end of the experiment. For comparison of young versus elderly mice, 4 month old (Group V) and 16-month-old (Group VI) control mice were used.
“We evaluated the changes in antioxidant levels, PI3K/Akt levels, and Nrf2 levels. We also examined how D-gal and GNL treated pathological aging changes.”
Administration of GNL induced a significant increase in spatial learning and memory with spontaneously altered behavior. Enhancing anti-oxidant and anti-inflammatory effects and activating PI3K/Akt were the mechanisms that mediated this effect. Further, GNL treatment upregulated Nrf2 and HO-1 to reduce oxidative stress and apoptosis. This was confirmed using 99mTc-HMPAO brain flow gamma bioassays.
“Thus, our data suggested GNL as a promising agent for treating neuroinflammation-induced cognitive impairment.”
Read the full paper: DOI: https://doi.org/10.18632/aging.205677
Corresponding Authors: Peramaiyan Rajendran, Fatma J. Al-Saeedi
Corresponding Emails: prajendran@kfu.edu.sa, fatma.alsaeedi@ku.edu.kw
Keywords: D-galactose, geraniol, cognitive disorder, Nrf2, 99mTc-HMPAO, apoptosis
Click here to sign up for free Altmetric alerts about this article.
About Aging:
Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
Please visit our website at www.Aging-US.com and connect with us:
Facebook
X, formerly Twitter
Instagram
YouTube
LinkedIn
Reddit
Pinterest
Spotify, and available wherever you listen to podcasts
Click here to subscribe to Aging publication updates.
For media inquiries, please contact media@impactjournals.com.
Aging (Aging-US) Journal Office
6666 E. Quaker Str., Suite 1B
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1
###
END
DALLAS (SMU) – A new study by SMU psychologists shows interpersonal racial discrimination and other forms of violence can impact the mental health of adolescents in the justice system.
The research advocates for a more holistic approach to mental health intervention, emphasizing the importance of considering adolescents' experiences of interpersonal racial discrimination alongside other more recognized forms of violence. By acknowledging and addressing these intersecting factors, stakeholders can better tailor support systems to meet ...
University of Florida engineers have developed a method for 3D printing called vapor-induced phase-separation 3D printing, or VIPS-3DP, to create single-material as well as multi-material objects. The discovery has the potential to advance the world of additive manufacturing.
Yong Huang, Ph. D., a professor in UF’s department of mechanical and aerospace engineering, said the printing process he and colleagues developed allows manufacturers to create custom-made objects economically and sustainably. The novel approach was reported Tuesday in the journal Nature Communications.
“It is more economical and much simpler than current ...
“Our results reveal that MIA-602 may be a useful treatment for Doxorubicin-resistant AML [...]”
BUFFALO, NY- April 10, 2024 – A new research paper was published in Oncotarget's Volume 15 on April 8, 2024, entitled, “Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia.”
Acute myeloid leukemia (AML) is characterized by the rapid proliferation of mutagenic hematopoietic progenitors in the bone marrow. Conventional therapies include chemotherapy and bone marrow stem cell transplantation; however, they are often associated with poor prognosis. Notably, growth hormone-releasing hormone (GHRH) ...
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, APRIL 10, 2024
MINNEAPOLIS – A changing climate may be linked to growing death and disability from stroke in regions around the world, according to a study published in the April 10, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. Researchers found over three decades that non-optimal temperatures, those above or below temperatures associated with the lowest death rates, were increasingly linked to death and disability due to stroke. The study does not prove that climate change causes ...
UNIVERSITY PARK, Pa. — Marketing is one of the most effective ways for an early-stage business-to-business (B2B) startup firm to grow, yet nearly half of such firms that would benefit from it choose not to do any marketing, according to the findings of a paper co-authored by a Smeal College of Business professor and published in the journal Industrial Marketing Management.
The researchers focused on systematic marketing — where a firm has an ongoing process of collecting and using customer data to improve its offerings, communications and distribution programs. They specifically examined which startup firms conduct systematic marketing, what causes them to do so and what ...
The U.S. Department of Energy’s (DOE) Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program is now accepting proposals for high-impact, computationally intensive research projects in a broad array of science, engineering and computer science domains. Proposals must be submitted between April 10 and June 14.
The INCITE program aims to accelerate scientific discoveries and technological innovations by awarding researchers with substantial allocations of supercomputer time and supporting resources at the Argonne Leadership Computing Facility (ALCF) and the Oak Ridge Leadership Computing Facility (OLCF). The ALCF and OLCF are DOE Office ...
Organisations that fail to identify or swiftly expel “institutional parasites” risk long-term damage, academics from leading British and Finnish business schools have warned.
In a paper published in the respected Academy of Management Review, they argue that the increasingly complex and opaque nature of many organisations provides fertile ground for institutional parasites – such as suppliers or other key external partners and employees.
Dr Jukka Rintamäki from Finland’s Aalto University School of Business, Dr Simon Parker from Nottingham University Business School and Professor Andre Spicer, Professor ...
WASHINGTON (April 10, 2024) — Citizen scientists have long contributed to the collection and observation of natural events - from weather watchers to wildlife trackers – with thousands of organized community projects spanning decades. Beginning in 2020, the COVID-19 pandemic gave rise to an explosion of novice infectious disease detectives adding to the collection of science-enthusiasts.
To give these new disease detectives more tools for their craft, a new book written by two Georgetown University global health researchers, “Outbreak ...
A University of Tennessee Extension specialist has been selected to assist land-grant university teams implementing grants through the Extension Collaboration on Immunization Teaching and Engagement (EXCITE), a national effort to encourage adult vaccinations in rural areas and among underserved communities.
Laura Clark, UT Extension state specialist in family and consumer sciences, will serve as a national EXCITE Bridge Grant coach and work with six land-grant universities that are grant recipients through the program. Clark has worked for UT Extension for six years, ...
A country’s economic prosperity is linked with improved well-being in its residents, according to a study published April 10, 2024 in the open-access journal PLOS ONE by Feng Huang from the Chinese Academy of Sciences, and colleagues.
Philosophers have long pondered the fraught relationship between money and happiness. Aristotle and Solon argued against the euphoric powers of wealth, while the Easterlin Paradox suggests that a nation’s economic fortitude can influence its residents’ health and happiness. Little evidence exists to support this claim in China, especially after the country’s recent economic expansion and rapid industrialization.
Huang and colleagues ...
