(Press-News.org) Osaka, Japan – Probiotics offer a range of health benefits, but their adverse effects can occasionally lead to bacteremia, wherein bacteria circulate in the bloodstream throughout the body. In Japan, Clostridium butyricum (C. butyricum) MIYAIRI 588 is commonly used, yet the prevalence and characteristics of bacteremia caused by this strain, as well as its bacteriological and genetic profile, remain unknown.
A research team from the Graduate School of Medicine, Osaka University, found an association between bacteremia and probiotics from a study of the genetic materials of bacteria in hospitalized patients with bacteremia.
From September 2011 to February 2023, Osaka University Hospital documented 6,576 cases of positive blood cultures. Among these, C. butyricum was detected in five cases (0.08%). Whole-genome sequencing revealed that all five strains of C. butyricum-causing bacteremia were derived from probiotics. In two of these cases, no clear reason for appropriate oral intake of the probiotics could be identified, and one patient died within 90 days after the bacteremia diagnosis.
"Probiotics can provide a variety of health benefits, but this study shows that even such agents can present with rare but serious adverse events," says study lead author Ryuichi Minoda Sada. "Our findings underscore the risk for bacteremia resulting from probiotic use, especially in hospitalized patients, necessitating judicious prescription practices."
It is expected that the results of this study will increase awareness of the potential health risks associated with probiotics. It is recommended to avoid aimless and unnecessary prescribing of probiotics, especially in hospitalized patients undergoing immunosuppressive treatment.
###
The article, “Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan,” was published in Emerging Infectious Diseases at DOI: http://doi.org/10.3201/eid3004.231633
About Osaka University
Osaka University was founded in 1931 as one of the seven imperial universities of Japan and is now one of Japan's leading comprehensive universities with a broad disciplinary spectrum. This strength is coupled with a singular drive for innovation that extends throughout the scientific process, from fundamental research to the creation of applied technology with positive economic impacts. Its commitment to innovation has been recognized in Japan and around the world, being named Japan's most innovative university in 2015 (Reuters 2015 Top 100) and one of the most innovative institutions in the world in 2017 (Innovative Universities and the Nature Index Innovation 2017). Now, Osaka University is leveraging its role as a Designated National University Corporation selected by the Ministry of Education, Culture, Sports, Science and Technology to contribute to innovation for human welfare, sustainable development of society, and social transformation.
Website: https://resou.osaka-u.ac.jp/en
END
When good bacteria go bad - New links between bacteremia and probiotic use
Researchers from Osaka University find that all identified C. butyricum bacteremia strains were probiotic derivatives using whole-genome sequencing .
2024-05-02
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
MCG scientists identify new treatment target for leading cause of blindness
2024-05-02
Medical College of Georgia scientists report that a gene previously implicated in the development of atherosclerotic lesions in coronary arteries could be key to understanding why many people don’t benefit from the most used therapy for neovascular age-related macular degeneration (AMD), a leading cause of blindness.
AMD is a condition characterized by abnormal blood vessel growth in the back of the eye. It is highly prevalent in the elderly and people with diabetes, obesity, and many other chronic metabolic diseases. Excessive vascular growth damages the macula, the part of the eye that translates light into image signals.
Anti-VEGF therapy, which blocks vascular ...
Promising new treatment strategy for deadly flu-related brain disorders
2024-05-02
Osaka, Japan – It might start simply, with a cough or sneeze…but in some cases, the flu virus can make its way to your brain, causing serious symptoms or even death through a disease known as influenza-associated encephalopathy (IAE).
Now, in a study published in Acta Neuropathologica, researchers have revealed that IAE may be caused by the virus entering the brain through a specific cell type, and have identified possible treatment strategies.
Although IAE is increasingly common, surprisingly little is known about ...
Scientists’ new approach in fight against counterfeit alcohol spirits
2024-05-02
In the shadowy world of counterfeit alcoholic spirit production, where profits soar and brands are exploited, the true extent of this illegal market remains shrouded.
Now scientists from the International Centre for Brewing and Distilling (ICBD) at Heriot-Watt University, in Edinburgh, Scotland, working alongside Dr John Edwards of Process NMR Associates, based in New York, are compiling a database to test, compare and log counterfeit spirits.
The research has featured in a paper, titled, Worldwide Illicit and Counterfeit ...
Cost-effective, high-capacity, and cyclable lithium-ion battery cathodes
2024-05-02
Charge-recharge cycling of lithium-superrich iron oxide, a cost-effective and high-capacity cathode for new-generation lithium-ion batteries, can be greatly improved by doping with readily available mineral elements.
The energy capacity and charge-recharge cycling (cyclability) of lithium-iron-oxide, a cost-effective cathode material for rechargeable lithium-ion batteries, is improved by adding small amounts of abundant elements. The development, achieved by researchers at Hokkaido University, Tohoku University, and Nagoya Institute of Technology, is reported in the journal ACS Materials Letters.
Lithium-ion batteries have become indispensable in modern life, used in a multitude ...
Artificial intelligence enhances monitoring of threatened marbled murrelet
2024-05-02
CORVALLIS, Ore. – Artificial intelligence analysis of data gathered by acoustic recording devices is a promising new tool for monitoring the marbled murrelet and other secretive, hard-to-study species, research by Oregon State University and the U.S. Forest Service has shown.
The threatened marbled murrelet is an iconic Pacific Northwest seabird that’s closely related to puffins and murres, but unlike those birds, murrelets raise their young as far as 60 miles inland in mature and old-growth forests.
“There are very few species like it,” said co-author Matt Betts of the OSU College of Forestry. “And there’s no ...
The solution to kidney bleeding and recovery lies within a hemostasis sponge, using the inherent capabilities of the kidneys
2024-05-02
Professor Dong-Woo Cho from the Department of Mechanical Engineering along with Jae Yun Kim, a PhD candidate, from the School of Interdisciplinary Bioscience and Bioengineering and Tugce Sen, a PhD student, from Department of Mechanical Engineering at POSTECH, teamed up with Professor Jae Yeon Lee from Daegu Haany University's Department of Companion Animal Health. Together, they crafted a material aimed at swiftly staunching kidney bleeding and facilitating wound recovery. Their research featured in the online edition of Biomaterials, an ...
Sylvester Cancer adding cellular therapy to its arsenal against metastatic melanoma
2024-05-02
MIAMI, FLORIDA (May 1, 2024) – Patients in South Florida with metastatic melanoma will soon have access to the first cellular therapy for this advanced form of skin cancer, following its recent approval by the Food and Drug Administration (FDA). The therapy, known as tumor-infiltrating lymphocyte therapy, or TIL, uses patients’ own immune cells to battle their cancer. It will be available to patients at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine as South Florida’s only center offering ...
Study finds biomarkers for psychiatric symptoms in patients with rare genetic condition 22q
2024-05-02
A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to the rare genetic condition 22q11.2 deletion syndrome, or 22q. It found unique biomarkers that could identify patients with 22q who may be more likely to develop schizophrenia or psychiatric conditions, including psychosis, which is commonly associated with 22q. The research was published in the journal Metabolomics.
People with 22q are missing a piece of chromosome 22 that contains more than 30 genes. This loss can lead to a variety of health challenges, ...
Medical school scientist creates therapy to kill hypervirulent bacteria
2024-05-02
University of Central Florida College of Medicine researcher Renee Fleeman is on a mission to kill drug-resistant bacteria, and her latest study has identified a therapy that can penetrate the slime that such infections use to protect themselves from antibiotics.
In a study published recently in Cell Reports Physical Science, Fleeman showed that an antimicrobial peptide from cows has potential for treating incurable infections from the bacterium Klebsiella pneumoniae. The bacteria, commonly found in the intestines, is usually harmless. ...
New study supports psilocybin’s potential as an antidepressant
2024-05-02
Psilocybin - the active ingredient in “magic” mushrooms - is a more effective treatment for symptoms of depression than controls, providing further support for its potential as an antidepressant, suggests a study published by The BMJ today.
The researchers say the findings are encouraging but “further research is needed to clarify the factors that maximise psilocybin’s treatment potential for symptoms of depression.”
Depression affects an estimated 300 million ...
LAST 30 PRESS RELEASES:
Twelve questions to ask your doctor for better brain health in the new year
Microelectronics Science Research Centers to lead charge on next-generation designs and prototypes
Study identifies genetic cause for yellow nail syndrome
New drug to prevent migraine may start working right away
Good news for people with MS: COVID-19 infection not tied to worsening symptoms
Department of Energy announces $179 million for Microelectronics Science Research Centers
Human-related activities continue to threaten global climate and productivity
Public shows greater acceptance of RSV vaccine as vaccine hesitancy appears to have plateaued
Unraveling the power and influence of language
Gene editing tool reduces Alzheimer’s plaque precursor in mice
TNF inhibitors prevent complications in kids with Crohn's disease, recommended as first-line therapies
Twisted Edison: Bright, elliptically polarized incandescent light
Structural cell protein also directly regulates gene transcription
Breaking boundaries: Researchers isolate quantum coherence in classical light systems
Brain map clarifies neuronal connectivity behind motor function
Researchers find compromised indoor air in homes following Marshall Fire
Months after Colorado's Marshall Fire, residents of surviving homes reported health symptoms, poor air quality
Identification of chemical constituents and blood-absorbed components of Shenqi Fuzheng extract based on UPLC-triple-TOF/MS technology
'Glass fences' hinder Japanese female faculty in international research, study finds
Vector winds forecast by numerical weather prediction models still in need of optimization
New research identifies key cellular mechanism driving Alzheimer’s disease
Trends in buprenorphine dispensing among adolescents and young adults in the US
Emergency department physicians vary widely in their likelihood of hospitalizing a patient, even within the same facility
Firearm and motor vehicle pediatric deaths— intersections of age, sex, race, and ethnicity
Association of state cannabis legalization with cannabis use disorder and cannabis poisoning
Gestational hypertension, preeclampsia, and eclampsia and future neurological disorders
Adoption of “hospital-at-home” programs remains concentrated among larger, urban, not-for-profit and academic hospitals
Unlocking the mysteries of the human gut
High-quality nanodiamonds for bioimaging and quantum sensing applications
New clinical practice guideline on the process for diagnosing Alzheimer’s disease or a related form of cognitive impairment or dementia
[Press-News.org] When good bacteria go bad - New links between bacteremia and probiotic useResearchers from Osaka University find that all identified C. butyricum bacteremia strains were probiotic derivatives using whole-genome sequencing .