PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Catheter-directed mechanical thrombectomy system demonstrates safety and effectiveness in patients with pulmonary embolism

Results from APEX-AX trial finds significant improvement in right ventricle function and minimal major adverse events

Catheter-directed mechanical thrombectomy system demonstrates  safety and effectiveness in patients with pulmonary embolism
2024-05-03
(Press-News.org) Long Beach, Calif. – May 3, 2024 – New data from the Acute Pulmonary Embolism Extraction Trial with the AlphaVac System (APEX-AX) demonstrated that catheter-directed mechanical thrombectomy is safe and effective in patients with acute intermediate-risk pulmonary embolism (PE) with significant improvement in the right ventricle (RV) function and minimal major adverse events. The safety and efficacy results from the prospective trial were presented today as late-breaking science at the Society for Cardiovascular Angiography & Interventions (SCAI) 2024 Scientific Sessions.

 

Pulmonary embolism (PE), a blood clot that blocks and stops blood flow to an artery in the lung, is common and often life-threatening. PE represents the third-leading cause of cardiovascular mortality with 100,000 to 180,000 deaths per year. Catheter-directed therapies continue to evolve to address the large population of acute PE patients.

 

The APEX-AV trial is a prospective, single-arm, multicenter investigational device exemption trial in which patients with acute intermediate-risk PE were treated with the AlphaVac F1885 aspiration system. The primary efficacy endpoint was a change in the right ventricle-to-left ventricle (RV/LV) ratio from baseline to 48 hours post-procedure on core lab–adjudicated computed tomography angiography. The primary safety endpoint was a composite of 48 hours post-procedure major adverse events: device-related death, major bleeding, and device-related serious adverse events.

 

Among the 122 patients treated at 25 U.S. sites, the average reduction in the RV/LV ratio was 0.45 with a 35.5% mean percentage reduction in the overall clot burden from the baseline at 48 hours post-procedure. Five patients had major adverse events within the 48-hour visit and no death was reported. Lastly, procedural times were short with a mean procedural time of 37.2 ± 17.7 minutes.

 

“Pulmonary emboli can be extremely dangerous and require effective and prompt action,” said William Brent Keeling, MD, Associate Professor at the Emory School of Medicine, and lead author of the study. “Catheter-directed mechanical thrombectomy using a new aspiration system can achieve excellent thrombus removal with a wonderful safety profile, thus enabling more tools in our armamentarium for the treatment of acute PE.”

 

Session Details:

“Evaluating the safety and efficacy of the AlphaVac F1885 system in acute Intermediate risk PE patients: APEX-AV trial” Friday, May 3, 2024; 2:14-2:21 PM PT Long Beach Convention Center, 104A, First Level  

###

 

About Society for Cardiovascular Angiography & Interventions (SCAI)

 

The Society for Cardiovascular Angiography & Interventions, established in 1978, stands as the primary nonprofit medical society dedicated to representing invasive and interventional cardiology. SCAI's mission is to guide the global interventional cardiovascular community by fostering education, advocacy, research, and upholding standards for quality patient care. For more than 40 years, SCAI has exemplified professional excellence and innovation worldwide, cultivating a reputable community of over 4,500 members committed to advancing medical science and providing life-saving care for individuals, both adults and children, affected by cardiovascular disease. For more information, visit https://scai.org/. 

 

For more information about the SCAI 2024 Scientific Sessions, visit https://scai.org/scai-2024-scientific-sessions. Follow @SCAI on X (formerly Twitter) and on LinkedIn for the latest heart health news and use #SCAI2024 to follow the latest discussions.

 

END


[Attachments] See images for this press release:
Catheter-directed mechanical thrombectomy system demonstrates  safety and effectiveness in patients with pulmonary embolism

ELSE PRESS RELEASES FROM THIS DATE:

Novel thrombectomy system demonstrates positive safety and feasibility results in treating acute pulmonary embolism

Novel thrombectomy system demonstrates positive safety and feasibility results in treating acute pulmonary embolism
2024-05-03
Long Beach, Calif. – May 3, 2024 – Late-breaking data from the ENGULF trial showed that a novel dual-action thrombectomy device was effective and safe in treating acute pulmonary embolism (PE). The safety and effectiveness results were presented today as late-breaking science at the Society for Cardiovascular Angiography & Interventions (SCAI) 2024 Scientific Sessions and simultaneously published in JSCAI.   PE is a serious cardiovascular event where a blood clot causes issues with blood flow and oxygen levels in the lungs. It can be ...

Biomimetic transcatheter aortic heart valve offers new option for aortic stenosis patients

Biomimetic transcatheter aortic heart valve offers new option for aortic stenosis patients
2024-05-03
Long Beach, Calif. – May 3, 2024 – Recent findings from a study on a transcatheter heart valve (THV) system, which includes a new class of transcatheter aortic valve, showed positive results in the device's ability to function as a healthy and natural aortic valve in patients with aortic stenosis (AS). The late-breaking data will be presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2024 Scientific Sessions.   AS is a thickening and narrowing of the aortic valve that can reduce blood flow to ...

SMART trial reaffirms hemodynamic superiority of TAVR self-expanding valve in aortic stenosis patients with a small annulus over time and regardless of age

SMART trial reaffirms hemodynamic superiority of TAVR self-expanding valve in aortic stenosis patients with a small annulus over time and regardless of age
2024-05-03
Long Beach, Calif. – May 3, 2024 – Additional analysis from the SMall Annuli Randomized To Evolut or SAPIEN (SMART) study demonstrated clinical non-inferiority of self-expanding valves (SEV) versus balloon-expandable valves (BEV) in aortic stenosis patients undergoing transcatheter aortic valve replacement (TAVR) and confirmed valve performance superiority over time based on hemodynamics. Data also showed similar positive results in two age groups (< or ≥ 80 years old). The late-breaking results were presented today at the Society for Cardiovascular Angiography & Interventions ...

Metastatic prostate cancer research: PSMAfore follow-on study favors radioligand therapy over change to androgen receptor pathway inhibition

Metastatic prostate cancer research: PSMAfore follow-on study favors radioligand therapy over change to androgen receptor pathway inhibition
2024-05-03
Study Title: Efficacy of [177Lu]Lu-PSMA-617 versus ARPI change in taxane-naive patients with metastatic castration-resistant prostate cancer by pre-randomization ARPI (PSMAfore) Publication: American Urological Association Annual Meeting Plenary, May 3, 2024 Dana-Farber Cancer Institute author: Xiao X. Wei, MD Summary: In a follow-on analysis of results from the phase 3 PSMAfore study, clinical investigators from Dana-Farber and elsewhere found that clinical outcomes consistently favored 177Lu-PSMA-617 over a change from one androgen receptor pathway inhibitor (ARPI) to another, regardless of which ARPI patients received first. ...

Studies highlight need for tailored treatment options for women with peripheral artery disease

Studies highlight need for tailored treatment options for women with peripheral artery disease
2024-05-03
Late-Breaking Data Shows Endovascular Therapy Results in One-Third Reduction in Post-Procedural Complications for Women with PAD   Women and Asian Americans Less Likely to Undergo Endovascular Revascularization for PAD Compared to Men and Other Races    Long Beach, Calif. – May 3, 2024 – New clinical results highlight the need for inclusive approaches and comprehensive examinations of treatment options for peripheral artery disease (PAD), including endovascular therapy and revascularization. The data ...

Women and Black patients less likely to receive catheter-based treatment for pulmonary embolism

Women and Black patients less likely to receive catheter-based treatment for pulmonary embolism
2024-05-03
Long Beach, Calif. – May 3, 2024 – New data from the REAL-PE analysis investigated catheter-based pulmonary embolism (PE) treatment, showing women and Black people were less frequently treated with minimally invasive therapy compared to men or non-Black patients. The late-breaking results were presented today at the Society for Cardiovascular Angiography & Interventions (SCAI) 2024 Scientific Sessions.                                                                                                              ...

Pilot program improves well-being of families during advanced care planning

2024-05-03
WASHINGTON (May 3, 2024) – Children with life-limiting rare diseases and their caregivers face tremendous stress and anxiety about the heart-breaking decisions before them. A new intervention – designed at Children’s National Hospital to support the palliative needs of these families – improved their spiritual and emotional well-being, according to new research published in the journal, Pediatrics.    Called FACE Rare (FAmily CEntered Pediatric Advance Care Planning Intervention for Rare Diseases), the counseling tools were found to be safe, effective and increased feelings of peace among families in this underserved ...

The key role of Galectin-3 in brain tumour development

2024-05-03
A research group at the Department of Biochemistry and Molecular Biology of the University of Seville has made a significant advance by discovering the crucial role of the protein Galectin-3 in the progression of various types of brain tumours. In these tumours, the most abundant immune system cells, microglia and macrophages, overexpress Galectin-3, which creates an immunosuppressed environment which inhibits the action of other immune cells against cancer cells. In vitro findings have shown that specific inhibition of Galectin-3 in microglial cells promotes expression of proinflammatory markers and reverses the presence of key immunosuppressive ...

Announcing Junevity as Tier 3 Sponsor of ARDD 2024

Announcing Junevity as Tier 3 Sponsor of ARDD 2024
2024-05-03
The University of Copenhagen is excited to announce Junevity as a Tier 3 Sponsor of the 11th Aging Research & Drug Discovery Meeting, the world's largest conference on aging research in the biopharmaceutical industry that will transpire on August 26 - August 30, 2024 on-site at the Ceremonial Hall, University of Copenhagen, and online. Junevity is rewinding diseases of aging with novel transcription factor medicines. Based on 6 years of breakthrough research at UCSF, Junevity's REWINDTM platform identifies new targets based on large-scale genomics, machine learning, and cell aging experiments. Junevity is advancing multiple therapeutic programs towards ...

Climate change amplifies severity of combined wind-rain extremes over the UK and Ireland

2024-05-03
Climate change will cause an increase in extreme winter storms combining strong winds and heavy rainfall over the UK and Ireland, new research has shown. The new study was led by experts at Newcastle University and the Met Office and investigated how future climate change may influence compound wind-rain extremes, which are events where extreme wind and rainfall occur simultaneously. The researchers analysed data from climate simulations covering control (1981-2000) and future (2060-2081) periods, ...

LAST 30 PRESS RELEASES:

To catch financial rats, a better mousetrap

Mapping the world's climate danger zones

Emory heart team implants new blood-pumping device for first time in U.S.

Congenital heart defects caused by problems with placenta

Schlechter named Cancer Moonshot Scholar

Two-way water transfers can ensure reliability, save money for urban and agricultural users during drought in Western U.S., new study shows

New issue of advances in dental research explores the role of women in dental, clinical, and translational research

Team unlocks new insights on pulsar signals

Great apes visually track subject-object relationships like humans do

Recovery of testing for heart disease risk factors post-COVID remains patchy

Final data and undiscovered images from NASA’s NEOWISE

Nucleoporin93: A silent protector in vascular health

Can we avert the looming food crisis of climate change?

Alcohol use and antiobesity medication treatment

Study reveals cause of common cancer immunotherapy side effect

New era in amphibian biology

Harbor service, VAST Data provide boost for NCSA systems

New prognostic model enhances survival prediction in liver failure

China focuses on improving air quality via the coordinated control of fine particles and ozone

Machine learning reveals behaviors linked with early Alzheimer’s, points to new treatments

Novel gene therapy trial for sickle cell disease launches

Engineering hypoallergenic cats

Microwave-induced pyrolysis: A promising solution for recycling electric cables

Cooling with light: Exploring optical cooling in semiconductor quantum dots

Breakthrough in clean energy: Scientists pioneer novel heat-to-electricity conversion

Study finds opposing effects of short-term and continuous noise on western bluebird parental care

Quantifying disease impact and overcoming practical treatment barriers for primary progressive aphasia

Sports betting and financial market data show how people misinterpret new information in predictable ways

Long COVID brain fog linked to lung function

Concussions slow brain activity of high school football players

[Press-News.org] Catheter-directed mechanical thrombectomy system demonstrates safety and effectiveness in patients with pulmonary embolism
Results from APEX-AX trial finds significant improvement in right ventricle function and minimal major adverse events