(Press-News.org) WASHINGTON, June 17, 2024 — L-DOPA is the best drug we have for Parkinson’s disease, but its molecular mirror image, D-DOPA, causes dangerous side effects. Making L-DOPA without also making D-DOPA is surprisingly hard and requires a specific kind of molecule to pull off. But that specific molecule must be made from a different and equally specific molecule. In this video, our host, George Zaidan, explains how one of the winners of the 2001 Nobel Prize in Chemistry pulled it off, and why "chiral synthesis," as it's called, is really just turtles all the way down. https://youtu.be/_cb09XB07LQ?si=BuMEI5fOuHmuQlkZ
Reactions is a video series produced by the American Chemical Society and PBS Digital Studios. Subscribe to Reactions at http://bit.ly/ACSReactions and follow us on X, formerly Twitter @ACSReactions.
The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS’ mission is to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and all its people. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, eBooks and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a leader in scientific information solutions, its CAS division partners with global innovators to accelerate breakthroughs by curating, connecting and analyzing the world’s scientific knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.
To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.
Follow us: Twitter | Facebook | Instagram
END
Making this Parkinson's drug is just turtles all the way down (video)
2024-06-17
ELSE PRESS RELEASES FROM THIS DATE:
Camelid nanobodies: Transforming food allergen analysis
2024-06-17
Recent advancements show nanobodies from camelid antibodies excel in food allergen detection with superior stability, specificity, and cost-effectiveness. This innovative approach aims to improve accuracy and efficiency, crucial for preventing severe allergic reactions. The study highlights nanobodies' potential in reliable immunoassays, addressing rising food allergies and enhancing safety measures.
Food allergies pose significant health risks, affecting millions worldwide, with the prevalence rising over the past decades. Traditional detection methods, such as monoclonal and polyclonal antibodies, are often costly, labor-intensive, and prone to cross-reactions. The need for ...
Federal study examines care following nonfatal overdose among Medicare beneficiaries; identifies effective interventions and gaps in care
2024-06-17
Researchers from the Substance Abuse and Mental Health Services Administration (SAMHSA), the National Institutes of Health’s (NIH) National Institute on Drug Abuse (NIDA), Centers for Medicare & Medicaid Services (CMS), and the Centers for Disease Control and Prevention (CDC) found that among a cohort of 137,000 Medicare beneficiaries who experienced a nonfatal overdose in 2020, almost 24,000 (17.4%) experienced a subsequent nonfatal overdose, and about 1,300 (1%) died from overdose in the following year. Results were published today in JAMA Internal Medicine, identifying both effective interventions and significant gaps in care.
“People who have experienced ...
Maternal inheritance of Alzheimer’s disease tied to increased risk of developing disease
2024-06-17
KEY TAKEAWAYS
Mass General Brigham researchers analyzed 4,400 cognitively unimpaired adults with amyloid imaging, finding increased amyloid in those who reported that their mothers had symptoms of Alzheimer’s disease (AD).
Increased amyloid, a biomarker of AD, was also found in those with a history of the disease on both sides of their family and in those whose fathers had an early onset of symptoms.
The study suggests that a person’s maternal versus paternal family history could ...
Epidemiologic features of recovery from SARS-CoV-2 infection
2024-06-17
About The Study: More than 1 in 5 adults did not recover within 3 months of SARS-CoV-2 infection in this cohort study. Recovery within 3 months was less likely in women and those with preexisting cardiovascular disease and more likely in those with COVID-19 vaccination or infection during the Omicron variant wave.
Corresponding Author: To contact the corresponding author, Elizabeth C. Oelsner, M.D., M.P.H., email eco7@cumc.columbia.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2024.17440)
Editor’s Note: Please see the article for additional information, ...
Electronic cigarettes vs varenicline for smoking cessation in adults
2024-06-17
About The Study: This randomized clinical trial found that varenicline and nicotine-containing electronic cigarettes were both effective in helping individuals in quitting smoking conventional cigarettes for up to 6 months.
Corresponding Author: To contact the corresponding author, Anna Tuisku, Ph.D., email anna.tuisku@lapha.fi.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamainternmed.2024.1822)
Editor’s Note: Please see the article ...
Risk factors for long COVID revealed
2024-06-17
NEW YORK, NY (June 14, 2024)--Early in the pandemic, many people who had SARS-Cov-2 infection or COVID-19 began to report that they couldn’t shake off their symptoms even after a month or more—unusually long for a viral infection of the upper respiratory tract—or developed new, persistent symptoms soon after the infection cleared.
Although it’s still not clear what causes post-COVID-19 conditions or “long COVID” (symptoms and conditions that develop, linger, or reoccur weeks or months after SARS-CoV-2 infection), a new study by researchers at Columbia University Vagelos College ...
Ancient polar sea reptile fossil is oldest ever found in Southern Hemisphere
2024-06-17
An international team of scientists has identified the oldest fossil of a sea-going reptile from the Southern Hemisphere – a nothosaur vertebra found on New Zealand’s South Island. 246 million years ago, at the beginning of the Age of Dinosaurs, New Zealand was located on the southern polar coast of a vast super-ocean called Panthalassa.
Reptiles first invaded the seas after a catastrophic mass extinction that devastated marine ecosystems and paved the way for the dawn of the Age of Dinosaurs almost 252 million years ago. Evidence for this evolutionary milestone has only been discovered in a few places around the world: on the Arctic island of Spitsbergen, northwestern North ...
Finding hidden genetic treasure: Study uncovers untapped diversity in historic wheat collection
2024-06-17
A decade-long collaborative study has discovered huge genetic potential that is untapped in modern wheat varieties.
The international study which appears in Nature reveals that at least 60% of the genetic diversity found in a historic collection of wheat is unused providing an unprecedented opportunity to improve modern wheat and sustainably feed a growing global population.
To make this discovery, a cross-institutional collaboration led by Dr Simon Griffiths, at the John Innes Centre and Professor Shifeng Cheng at the Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences (CAAS), studied the A.E. Watkins Landrace Collection, a ...
Researchers develop plant gene drive system for enhanced trait inheritance
2024-06-17
A collaborative research team led by QIAN Wenfeng from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences and Peking University has developed a plant gene drive system called CRISPR-Assisted Inheritance utilizing NPG1 (CAIN), which, according to the researchers, uses a toxin-antidote mechanism in the male germline to override Mendelian inheritance in plants.
Their findings were published in Nature Plants.
In nature, gene inheritance typically follows Mendel's laws, which provide an equal chance for alleles to pass on to ...
Children’s Tumor Foundation presents the 2024 Global NF Conference in Brussels: Shaping what’s next for NF
2024-06-17
(NEW YORK, NY and BRUSSELS, BELGIUM) - June 17, 2024 - The 2024 Global NF Conference, organized by the Children’s Tumor Foundation (CTF) and the European NF Group, and hosted by Children's Tumor Foundation Europe, is the foremost assembly defining the scientific and medical future of the genetic conditions neurofibromatosis and schwannomatosis (known collectively as NF). This global gathering, taking place from June 20-25 at THE EGG in Brussels, Belgium, will connect over 1,000 attendees for up-to-date knowledge and insights in the growing fields of NF research ...