Alzheimer disease and related dementia following hormone-modulating therapy in patients with breast cancer

JAMA Network Open

2024-07-16

(Press-News.org) About The Study: In this retrospective cohort study, hormone therapy was associated with protection against Alzheimer disease and related dementias in women age 65 or older with newly diagnosed breast cancer; the decrease in risk was relatively greater for Black women and women under age 75, while the protective effect of hormone-modulating therapy (HMT) diminished with age and varied by race in women. When deciding to use HMT for breast cancer in women age 65 years or more, clinicians should consider age, self-identified race, and HMT type in treatment decisions.

Corresponding author: To contact the corresponding author, Chao Cai, Ph.D., email caic@mailbox.sc.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi: 10.1001/jamanetworkopen.2024.22493)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.22493?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071624

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

AI tool successfully responds to patient questions in electronic health record

2024-07-16

As part of a nationwide trend, many more of NYU Langone Health’s patients during the pandemic started using electronic health record tools to ask their doctors questions, refill prescriptions, and review test results. Many patients’ digital inquiries arrived via a communications tool called In Basket, which is built into NYU Langone’s electronic health record (EHR) system, EPIC. While physicians have always dedicated time to managing EHR messages, they saw a more than 30% annual increase in recent years in the number of messages received daily, according an article by ...

New analysis of Cassini data yields insights into Titan’s seas

2024-07-16

UNDER EMBARGO UNTIL JULY 16, 2024, AT 11:00 AM ET ITHACA, N.Y. – A new study of radar experiment data from the Cassini-Huygens mission to Saturn has yielded fresh insights related to the makeup and activity of the liquid hydrocarbon seas near the north pole of Titan, the largest of Saturn’s 146 known moons. The key takeaway: Using data from several bistatic radar experiments, a Cornell University-led research team was able to separately analyze and estimate the composition and roughness of Titan’s sea surfaces, something previous analyses of monostatic radar data were unable to achieve. This will help pave the way for future combined ...

New sleep study aims to understand cognitive decline in women

2024-07-16

LA JOLLA, CA—Alzheimer’s disease, the most common type of dementia, currently affects twice as many women as men, with minority populations predicted to witness the most significant increase in cases in the coming years, according to the Centers for Disease Control and Prevention. Disturbances in sleep are well-known in dementia but have previously been explained as an outcome of the disease, not the cause. Increasing evidence, however, now implicates sleep disturbances with the development of dementia. In a bid to better understand the relationship between sleep and cognitive outcomes in women, scientists at the Scripps ...

Turning agricultural trash to treasure

2024-07-16

In California's Northern San Joaquin Valley, agricultural leftovers such as almond shells, fruit peels, and orchard trimmings can potentially be converted into sustainable bioproducts and biofuels – with the right technology. Today, Schmidt Sciences’ Virtual Institute on Feedstocks of the Future awarded new funding to a group investigating how to make better use of the diverse agricultural waste in the region. The group, “Building the Circular Bioeconomy in the North San Joaquin Valley” or BioCircular Valley, is co-led by the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), UC Berkeley, and BEAM Circular, ...

Adjuvant therapy for hepatocellular carcinoma after curative treatment: Several unanswered questions

2024-07-16

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and is the third leading cause of cancer-related deaths. The primary curative treatments for HCC are liver transplantation, hepatectomy, and local ablation. However, the recurrence rate of HCC following hepatectomy or ablation remains alarmingly high, up to 70%, severely impacting patient prognosis and overall survival (OS). To mitigate postoperative recurrence and improve patient outcomes, various adjuvant therapies have been explored. Despite the efficacy of several adjuvant treatments in reducing recurrence rates and enhancing survival, ...

Palliative care is underutilized in nursing homes

2024-07-16

INDIANAPOLIS – Palliative care, specialized medical care focusing on providing relief from the symptoms -- including pain -- and the stress of serious illness, is underutilized in nursing homes, despite the large number of nursing home residents living with a serious illness such as cancer, dementia, Parkinson’s disease, heart failure or chronic obstructive pulmonary disease. A qualitative study, published in the Journal of the American Geriatrics Society, analyzes lack of palliative ...

Understanding others: By age three, we can do this with mirror neurons

2024-07-16

Milan, July 15, 2024 – By the age of three, children are capable of understanding others, "mirroring" those they are with to imitate and anticipate their intentions. They are able to do it thanks to the sophisticated neurofunctional architecture that is necessary to understand others' intentions, the mirror neurons, that result already active at this age. It’s the result of a study published in the prestigious journal PNAS, led by the collaboration between Giacomo Rizzolatti of the University of ...

Oil and natural gas development in Permian is a key source of ozone pollution in Carlsbad Caverns National Park

2024-07-16

EMBARGO: THIS CONTENT IS UNDER EMBARGO UNTIL 9 A.M. U.S. EASTERN STANDARD TIME ON JULY 16. INTERESTED MEDIA MAY RECIVE A PREVIEW COPY OF THE JOURNAL ARTICLE IN ADVANCE OF THAT DATE OR CONDUCT INTERVIEWS, BUT THE INFORMATION MAY NOT BE PUBLISHED, BROADCAST, OR POSTED ONLINE UNTIL AFTER THE RELEASE WINDOW. New research shows that ozone concentrations at Carlsbad Caverns National Park frequently exceed Environmental Protection Agency health standards, likely due to oil and natural gas development in the Permian Basin and surrounding region. The work was led through the Department of Atmospheric Science at Colorado State University and is part of ...

E. coli variant may cause antimicrobial resistance in dogs, humans

2024-07-16

ITHACA, N.Y. – Researchers studying antimicrobial-resistant E. coli – the leading cause of human death due to antimicrobial resistance worldwide – have identified a mechanism in dogs that may render multiple antibiotic classes ineffective. The paper, which will publish July 16 in the journal Applied and Environmental Microbiology at 9:00am EST, opens up new avenues for therapies to treat both animals and humans – and establishes clinical infections in dogs as a surveillance approach for public health. The research team analyzed more than 1,000 genomes of the resistant ...

Ultrasonography of hepatocellular carcinoma: From diagnosis to prognosis

2024-07-16

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and one of the leading causes of cancer-related deaths worldwide. Early detection and accurate diagnosis are crucial for effective management and improved survival rates. Ultrasound (US) technology has significantly advanced and plays a pivotal role in the surveillance, diagnosis, and treatment of HCC. This paper delves into various ultrasound techniques and their clinical applications in HCC management. Two-dimensional gray-scale ultrasound is a fundamental imaging technique for HCC surveillance. ...

Alzheimer disease and related dementia following hormone-modulating therapy in patients with breast cancer

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: