PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Tackling cancer from the inside out: A deep dive into immune checkpoint inhibitors

Tackling cancer from the inside out: A deep dive into immune checkpoint inhibitors
2024-08-13
(Press-News.org) In the past two decades, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, showing promising results against various solid tumors. This study reviews recent developments in ICIs, focusing on new targets like T cell immunoreceptor with Ig and ITIM domains (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and lymphocyte activation gene-3 (LAG-3). These targets aim to overcome resistance mechanisms limiting the effectiveness of current therapies, such as anti-PD-1 and anti-CTLA-4. By identifying and developing these new ICIs, researchers hope to improve treatment outcomes and provide new therapeutic options for cancer patients.

Immunotherapy, especially immune checkpoint blockade (ICB), has transformed cancer treatment. However, many patients develop resistance to current treatments like anti-PD-1 and anti-CTLA-4. This resistance underscores the need for ongoing research to discover new immune checkpoint targets and enhance treatment efficacy. Based on these challenges, it is crucial to conduct in-depth studies to identify additional immune checkpoint inhibitors (ICIs) and develop combination therapies that can provide more effective cancer treatments.

Researchers from Guangdong Pharmaceutical University published a comprehensive review (DOI:10.20892/j.issn.2095-3941.2024.0055) in Cancer Biology & Medicine on May 24, 2024, highlighting recent progress in ICIs. The study, led by Xueqing Kong and colleagues, discusses novel immune checkpoint molecules and their clinical applications, aiming to improve cancer treatment outcomes.

The study explores the mechanisms behind resistance to current ICIs like anti-PD-1 and anti-CTLA-4 therapies. Researchers have identified new immune checkpoints, including T cell immunoreceptor with Ig and ITIM domains (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and lymphocyte activation gene-3 (LAG-3), which help tumors evade the immune system. Monoclonal antibodies targeting these molecules are in development and show promise for enhancing existing treatments. The review also highlights the benefits of combination therapies, such as pairing PD-1 inhibitors with anti-angiogenic agents, radiotherapy, or chemotherapy. These combined approaches have demonstrated improved outcomes in clinical trials. By integrating these new targets and strategies, the study aims to overcome the limitations of current ICIs, offering renewed hope and more effective options for cancer patients.

Dr. Rongxin Zhang, a leading immunologist at Guangdong Pharmaceutical University, commented, "The identification of new immune checkpoint targets marks a significant advancement in cancer immunotherapy. By understanding and targeting these novel molecules, we can develop more effective treatment strategies and overcome resistance mechanisms, ultimately improving patient outcomes."

The advancements in ICIs not only enhance current cancer treatment protocols but also pave the way for personalized medicine. By combining ICIs with other therapeutic modalities, researchers aim to create tailored treatment plans that address individual patient needs. These developments hold promise for reducing cancer recurrence rates and improving the overall survival of cancer patients.

###

References

DOI

10.20892/j.issn.2095-3941.2024.0055

Original Source URL

https://doi.org/10.20892/j.issn.2095-3941.2024.0055

Funding information

This study was supported by the National Natural Science Foundation of China (Grant Nos. 82173087 and 82203533).

About Cancer Biology & Medicine

Cancer Biology & Medicine (CBM) is a peer-reviewed open-access journal sponsored by China Anti-cancer Association (CACA) and Tianjin Medical University Cancer Institute & Hospital. The journal monthly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China. The journal is indexed in SCOPUS, MEDLINE and SCI (IF 5.6, 5 year IF 5.9), with all full texts freely visible to clinicians and researchers all over the world.

END

[Attachments] See images for this press release:
Tackling cancer from the inside out: A deep dive into immune checkpoint inhibitors

ELSE PRESS RELEASES FROM THIS DATE:

RPI Physicist Moussa N’Gom is using light to enhance nuclear security

RPI Physicist Moussa N’Gom is using light to enhance nuclear security
2024-08-13
Our nation’s security depends on the effective detection of nuclear materials at our borders and beyond. To address this challenge, Rensselaer Polytechnic Institute (RPI) physicist Moussa N’Gom, Ph.D., is leading research aimed at developing a quantum sensing probe to detect and characterize special nuclear materials precisely and without contact. Special nuclear materials are only mildly radioactive but can be used in nuclear explosives. The research is being conducted through RPI’s participation in the Consortium ...

The atmosphere in the room can affect strategic decision-making, study finds

2024-08-13
The atmosphere within a group can influence the outcome of strategic decision-making, according to a new study co-authored by Bayes Business School (formerly Cass).  Paula Jarzabkowski, Professor of Strategic Management at Bayes, along with researchers from University of Queensland, Macquarie University and Leuphana University of Lüneburg, found that different atmospheres led to people speaking and interacting in different ways that changed how they made sense of the strategy.   For instance, when the atmosphere was pensive, people were cautious about the way to proceed, whereas, when it was curious they felt ...

Study uncovers mutated driver genes in colorectal cancer: 9 novel to CRC and 24 previously undetected in any cancer

Study uncovers mutated driver genes in colorectal cancer: 9 novel to CRC and 24 previously undetected in any cancer
2024-08-13
The Institute of Intelligent Medical Research (IIMR) of BGI Genomics, in collaboration with Sweden’s Uppsala University, has published the largest multi-omics study of colorectal cancer (CRC) to date. The study aimed to understand the functional and prognostic impact of cancer-causing somatic mutations, revealing new genetic alterations and developing a new molecular classifier of tumor variants. This research was published in the journal Nature on August 7th, 2024. Unveiling New Genetic Landscapes The researchers analyzed the whole genomes and transcriptomes ...

Cricket physics: Science behind the modern bowler technique tricking batters

Cricket physics: Science behind the modern bowler technique tricking batters
2024-08-13
WASHINGTON, Aug. 13, 2024 – Key to winning a cricket match is tricking the other team’s batters – no small feat as bowlers bowl cricket balls nearly 100 miles per hour. In recent years, a bowling technique that has become popular involves keeping the arm almost entirely horizontal during delivery, notably used by Sri Lankan stars Lasith Malinga and Matheesha Pathirana. The aerodynamics of such deliveries have perplexed sports physicists. In Physics of Fluids, by AIP Publishing, researchers have started to unravel the mysteries of how ...

Measuring Martian winds with sound

Measuring Martian winds with sound
2024-08-13
WASHINGTON, Aug. 13, 2024 – Mars has a notoriously inhospitable environment, with temperatures that fluctuate dramatically over the course of a Martian day and average minus 80 degrees Fahrenheit. Its surface is mostly covered in red dust, with terrain typified by craters, canyons, and volcanoes. And its atmosphere is extremely thin, comprising only about 1% of the density of Earth’s. Needless to say, measuring wind speeds on the red planet is challenging. Martian landers have been able capture measurements — some gauging the cooling rate of heated materials ...

Posttraumatic stress disorder and type 2 diabetes outcomes in veterans

2024-08-13
About The Study: The findings of this cohort study of patients with comorbid posttraumatic stress disorder (PTSD) and type 2 diabetes suggest that PTSD is a modifiable risk factor associated with a modest reduction in microvascular complications. Further research is needed to determine whether findings are similar in non-Veterans Health Administration health care settings.  Corresponding Author: To contact the corresponding author, Jeffrey F. Scherrer, PhD, email jeffrey.scherrer@health.slu.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.27569) Editor’s ...

Smartwatch measures of outdoor exposure and nearsightedness in children

2024-08-13
About The Study: In this 1-year prospective cohort study of children with smartwatches, continuous outdoor exposure with at least 15 minutes accompanied with no less than 2,000 lux sunlight intensity was associated with less myopic shift. These findings suggest that future outdoor interventions should focus not only on the overall time outdoors but also on the effective outdoor exposure patterns, as a means to effectively prevent myopia (nearsightedness) in children.  Corresponding Authors: To ...

Lurie Children’s Hospital awarded $12 million by PCORI to study best approach to treat mild pneumonia in young children

2024-08-13
Ann & Robert H. Lurie Children’s Hospital of Chicago, in partnership with University of Utah Health, has been approved for $12 million in research funding by the Patient-Centered Outcomes Research Institute (PCORI) for a study that will compare two ways to use antibiotics in young children with mild pneumonia, one of the leading reasons children seek acute care, who are well enough to be cared for at home. The first approach is to prescribe and give antibiotics immediately, which is the current standard of care. The second way is to prescribe an antibiotic but not give it unless the child’s symptoms worsen or ...

PCORI announces $165 million in funding for new health research

PCORI announces $165 million in funding for new health research
2024-08-13
PCORI announces $165 million in funding for new health research   Approved awards support patient-centered comparative clinical effectiveness research (CER) on telehealth interventions, heart care and various health concerns Aug. 13, 2024 WASHINGTON, D.C. – The Patient-Centered Outcomes Research Institute (PCORI) today announced the approval of funding awards totaling more than $165 million for new patient-centered comparative clinical effectiveness research (CER), as well as research to improve methods and strengthen the science of engagement in patient-centered CER. Among the 10 CER studies awarded, three will evaluate the effectiveness of telehealth interventions ...

Study finds emergency department visits by children associated with water beads more than doubled from 2021 to 2022

2024-08-13
(COLUMBUS, Ohio) – Researchers from the Center for Injury Research and Policy and Central Ohio Poison Center at Nationwide Children’s Hospital have found more than an estimated 8,000 visits to U.S. emergency departments (EDs) associated with water beads from 2007 through 2022, and the number of these visits increased rapidly by more than 130% from 2021 to 2022. In a study published in American Journal of Emergency Medicine, researchers analyzed 16 years of data and call for a more comprehensive regulatory approach to prevent water bead-associated injuries. The increase in ...

LAST 30 PRESS RELEASES:

Reality check: making indoor smartphone-based augmented reality work

Overthinking what you said? It’s your ‘lizard brain’ talking to newer, advanced parts of your brain

Black men — including transit workers — are targets for aggression on public transportation, study shows

Troubling spike in severe pregnancy-related complications for all ages in Illinois

Alcohol use identified by UTHealth Houston researchers as most common predictor of escalated cannabis vaping among youths in Texas

Need a landing pad for helicopter parenting? Frame tasks as learning

New MUSC Hollings Cancer Center research shows how Golgi stress affects T-cells' tumor-fighting ability

#16to365: New resources for year-round activism to end gender-based violence and strengthen bodily autonomy for all

Earliest fish-trapping facility in Central America discovered in Maya lowlands

São Paulo to host School on Disordered Systems

New insights into sleep uncover key mechanisms related to cognitive function

USC announces strategic collaboration with Autobahn Labs to accelerate drug discovery

Detroit health professionals urge the community to act and address the dangers of antimicrobial resistance

3D-printing advance mitigates three defects simultaneously for failure-free metal parts 

Ancient hot water on Mars points to habitable past: Curtin study

In Patagonia, more snow could protect glaciers from melt — but only if we curb greenhouse gas emissions soon

Simplicity is key to understanding and achieving goals

Caste differentiation in ants

Nutrition that aligns with guidelines during pregnancy may be associated with better infant growth outcomes, NIH study finds

New technology points to unexpected uses for snoRNA

Racial and ethnic variation in survival in early-onset colorectal cancer

Disparities by race and urbanicity in online health care facility reviews

Exploring factors affecting workers' acquisition of exercise habits using machine learning approaches

Nano-patterned copper oxide sensor for ultra-low hydrogen detection

Maintaining bridge safer; Digital sensing-based monitoring system

A novel approach for the composition design of high-entropy fluorite oxides with low thermal conductivity

A groundbreaking new approach to treating chronic abdominal pain

ECOG-ACRIN appoints seven researchers to scientific committee leadership positions

New model of neuronal circuit provides insight on eye movement

Cooking up a breakthrough: Penn engineers refine lipid nanoparticles for better mRNA therapies

[Press-News.org] Tackling cancer from the inside out: A deep dive into immune checkpoint inhibitors