Slowing cognitive decline in major depressive disorder and mild cognitive impairment
JAMA Psychiatry
2024-10-30
(Press-News.org)
About The Study: This study showed that cognitive remediation and transcranial direct current stimulation, both targeting the prefrontal cortex, is efficacious in slowing cognitive decline in older adults at risk of cognitive decline, particularly those with remitted major depressive disorder (with or without mild cognitive impairment) and in those at low genetic risk for Alzheimer disease.
Corresponding Author: To contact the corresponding authors, email Benoit H. Mulsant, MD, MS, (benoit.mulsant@utoronto.ca) and Tarek K. Rajji, MD, (tarek.rajji@utsouthwestern.edu)
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(10.1001/jamapsychiatry.2024.3241)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2024.3241?guestAccessKey=25ef487c-b5bd-4cbe-aaca-da718af2b402&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=103024
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2024-10-30
About The Study: In this cross-sectional study of children and adults in the U.S., autism spectrum disorder diagnosis rates increased substantially between 2011 and 2022, particularly among young adults, female children and adults, and children from some racial or ethnic minority groups. Diagnosis prevalence trends generated using health system data can inform the allocation of resources to meet the service needs of this growing, medically complex population.
Corresponding Author: To contact the corresponding author, Luke P. Grosvenor, PhD, email luke.p.grosvenor@kp.org.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2024.42218)
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Background and objectives
Gelsemium elegans Benth (G. elegans) is a traditional medicinal plant; however, it is highly toxic, and toxicity varies significantly between species. The cause of this difference has not been clarified. Humantenirine is an important toxic alkaloid in G. elegans, and its metabolism has been poorly studied. This study aimed to compare the different metabolites formed by human liver microsomes, pig liver microsomes, and goat liver microsomes.
Methods
High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used to study the metabolism of humantenirine in human liver microsomes, ...
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[Press-News.org] Slowing cognitive decline in major depressive disorder and mild cognitive impairment
JAMA Psychiatry
