(Press-News.org) Past research has suggested that inflammation may contribute to the development and progression of dementia and that non-steroidal anti-inflammatory (NSAID) medications may help protect against dementia due to their anti-inflammatory effects. A new large prospective study published in the Journal of the American Geriatrics Society provides additional evidence, showing that long-term NSAID use is linked to a decreased risk of developing dementia.
In the population-based study of 11,745 adults with an average follow-up of 14.5 years, 9,520 participants had used NSAIDs at any given time, and 2,091 participants developed dementia. Long-term NSAID use was associated with a 12% reduced risk of developing dementia. Short- and intermediate-term use did not provide benefits. Also, the cumulative dose of NSAIDs was not associated with decreased dementia risk.
The findings suggest that prolonged, rather than intensive, use of anti-inflammatory medications may help protect against dementia.
“Our study provides evidence on possible preventive effects of anti-inflammatory medication against the dementia process. There is a need for more studies to further consolidate this evidence and possibly develop preventive strategies,” said corresponding author M. Arfan Ikram, MSc, MD, PhD, of Erasmus MC University Medical Center Rotterdam, in the Netherlands.
URL upon publication: https://onlinelibrary.wiley.com/doi/10.1111/jgs.19411
Additional Information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com.
About the Journal
Journal of the American Geriatrics Society is the go-to journal for clinical aging research. We provide a diverse, interprofessional community of healthcare professionals with the latest insights on geriatrics education, clinical practice, and public policy — all supporting the high-quality, person-centered care essential to our well-being as we age.
About Wiley
Wiley is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, X, LinkedIn and Instagram.
END
Can long-term use of anti-inflammatory medications prevent dementia?
2025-03-05
ELSE PRESS RELEASES FROM THIS DATE:
Review supports introducing small amounts of food allergens during early childhood
2025-03-05
A review in Clinical & Experimental Allergy concludes that exposing young children to small amounts of foods that they’re allergic to is safer than avoiding the foods altogether, which could be very dangerous if accidental exposure occurs.
The review notes that exposing preschool-aged children to small amounts of food allergens—called oral immunotherapy—can lessen the severity of a reaction following an accidental exposure. Also, delaying exposure until a later age misses the window ...
How are human activities affecting sea otters?
2025-03-05
Because of their high metabolic rates, sea otters are especially vulnerable to disturbances that can increase their energy needs. New research in The Journal of Wildlife Management reveals how human activities affect the behavior and energy expenditure of southern sea otters.
By studying southern sea otters over 5 years at 3 sites along the coast of California, investigators found evidence that on average, the likelihood of a group of sea otters being disturbed (which affects their ability to rest) is less than 10% when stimuli such as small craft are more than 29 meters away, although this threshold varies by location, group size, ...
Discriminated groups create safe spaces online
2025-03-05
Online threats, hatred and harassment have led people who feel discriminated against to create digital spaces where they can feel safe. According to a new thesis from the University of Gothenburg, these spaces are characterised by clear rules and constant maintenance and monitoring.
Much of social life today takes place online. Unfortunately, the worst aspects of interpersonal relationships also appear in the digital world. A study of 51 countries revealed that 38% of women had personally experienced online harassment. Bullying and harassment have led people to create their own digital safe spaces, which is the topic ...
How one researcher equipped with a smartphone is creating detailed reports on the insides of stranded sea creatures
2025-03-05
What inspired you to become a researcher?
My interest in research began with an early love for nature, particularly the ocean and its wildlife. Drawn to conservation, I am fascinated by how technology can help study and protect marine mammals.
Can you tell us about the research you’re currently working on?
This research focuses on using accessible 3D scanning technologies, like LiDAR-equipped mobile devices and UAV photogrammetry, to document and analyze stranded marine mammals. LiDAR (Light Detection and Ranging) is a remote sensing technology that uses laser pulses to determine the ...
Americans borrowed $74 billion last year to cover healthcare costs
2025-03-05
WASHINGTON, D.C. – March 5, 2025 – More than 31 million Americans (12%) report needing to borrow about $74 billion last year to pay for healthcare despite most having some form of health insurance, according to a new survey from West Health and Gallup. Nearly one-third (28%) report being “very concerned” that a major health event could throw them into debt.
The survey found almost 20% of Americans aged 49 and under needed to borrow money to cover medical costs compared with just 9% of those 50 to 64. Women between the ages of 50 and 64 were twice as likely as men in the same age group to say they had to borrow (12% vs. 6%). Two percent ...
Iconic Australian bird reveals hidden farming talent
2025-03-05
A beloved Australian bird best known for its stunning tail and powers of mimicry may have a cunning hidden talent.
New research has revealed the superb lyrebird to be a resourceful farmer, creating micro-habitats to host and fatten its prey before returning later to feast.
Scientists from La Trobe University observed the ground-dwelling birds working to create habitats suitable for their diet of worms, centipedes and spiders.
In a new paper published in the Journal of Animal Ecology, the researchers found that lyrebirds arranged litter and soil on the forest floor in ways that promote more ...
New method improves catalyst performance for hydrogenation reactions
2025-03-05
Recently, the research team led by Researcher WANG Guozhong from the Institute of Solid State Physics, the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has developed a method to precisely control the size of nickel particles in catalysts, improving their performance in hydrogenation reactions.
The related research results were published in Advanced Functional Materials.
Catalysts are essential in speeding up chemical reactions without being consumed, and the size of the metal particles in them plays a key role in their effectiveness. Larger particles have more high-coordination sites, while smaller ones are dominated ...
Cracking the code on gypsum and silica scaling in water desalination
2025-03-05
Mineral scaling, a significant issue in membrane desalination, reduces water recovery rates and diminishes system performance. Gypsum and silica, are two prevalent types of scaling, each form through different processes—crystallization for gypsum and polymerization for silica. These formation mechanisms lead to contrasting behaviors: gypsum scaling, marked by rapid kinetics and intrusive crystal growth, causes pore wetting, while silica scaling forms highly adhesive, irreversible layers. The impact of these scales on desalination efficiency underscores the need for a deeper understanding of their formation and mitigation.
On October 20, ...
Creativity boosts NAPLAN literacy and numeracy scores
2025-03-05
When ‘Elephant’ toothpaste erupts from the science lab, history deals up Pokémon playing cards, and maths bakes a batch of chocolate brownies, it might seem like chaos.
Yet, a groundbreaking study from University of South Australia researchers, shows that creativity plays an essential role in academic success, suggesting that students who think outside the box are more likely to excel in literacy and numeracy assessments.
It’s an important finding, particularly when the most recent National Assessment Program – Literacy and Numeracy (NAPLAN) data shows that one in three Australian students are behind in their numeracy ...
Beyond our solar system: scientists identify a new exoplanet candidate
2025-03-05
Scientists from UNSW Sydney have located a potential new exoplanet – a planet that orbits a star outside of our solar system – using a technique known as ‘transit timing variation’.
In research highlighted in a new paper, published today in The Astrophysical Journal, Scientia Senior Lecturer Ben Montet and PhD candidate Brendan McKee analysed changes in the timing of a known planet’s transit across its star, to infer the presence of a second exoplanet.
After ...