Gender-affirming hormone therapy and depressive symptoms among transgender adults

JAMA Network Open

2025-03-17

(Press-News.org) About The Study: In this longitudinal observational cohort study, gender-affirming hormone therapy was associated with lower rates of moderate-to-severe depressive symptoms, highlighting the importance of gender-affirming primary care models for transgender, nonbinary, and gender diverse patients.

Corresponding Author: To contact the corresponding author, Sari L. Reisner, ScD, MA, email sreisner@umich.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.0955)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Gender-affirming hormone therapy and depressive symptoms among transgender adults

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