Single treatment with MM120 (lysergide) in generalized anxiety disorder

JAMA

2025-09-04

(Press-News.org) About The Study: In participants with moderate to severe generalized anxiety disorder, a single dose of MM120 (lysergide D-tartrate) produced a dose-dependent reduction in anxiety. Lysergide, or lysergic acid diethylamide (LSD), is a semisynthetic psychedelic drug. An oral pharmaceutical formulation of LSD is MM120. These results support the dose-dependent efficacy of MM120 and inform the dose selection for phase 3 pivotal trials.

Corresponding Author: To contact the corresponding author, Daniel R. Karlin, MD, MA, email medaffairs@mindmed.co.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.13481)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Single treatment with MM120 (lysergide) in generalized anxiety disorder

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