EMBARGOED FOR RELEASE UNTIL 4:00 P.M. ET, WEDNESDAY, SEPTEMBER 10, 2025
Highlights:
Chronic insomnia—trouble sleeping at least three days a week for three months or more—could speed up brain aging.
People with chronic insomnia were 40% more likely to develop dementia or mild cognitive issues than people without insomnia.
Insomnia with perceived reduced sleep was associated with lower cognition comparable to being four years older.
Better sleep isn’t just beauty rest—it might protect your brain health.
MINNEAPOLIS — People with chronic insomnia may experience faster declines in memory and thinking skills as they age—along with brain changes that can be seen on imaging scans—than people who do not have chronic insomnia, according to a study published in the September 10, 2025, issue of Neurology®, the medical journal of the American Academy of Neurology.
The study found that people with chronic insomnia—trouble sleeping at least three days a week for three months or more—had a 40% higher risk of developing mild cognitive impairment or dementia than those without insomnia, which is the equivalent of 3.5 additional years of aging. The study does not prove that insomnia causes brain aging, it only shows an association.
“Insomnia doesn’t just affect how you feel the next day—it may also impact your brain health over time,” said study author Diego Z. Carvalho, MD, of the Mayo Clinic in Rochester, Minnesota, and a member of the American Academy of Neurology. “We saw faster decline in thinking skills and changes in the brain that suggest chronic insomnia could be an early warning sign or even a contributor to future cognitive problems.”
The study tracked a group of cognitively healthy older adults—2,750 people with an average age of 70—for an average of 5.6 years. Of participants, 16% had chronic insomnia.
At the start of the study, participants were asked whether they had been sleeping more or less than usual during the past two weeks. They also took yearly thinking and memory tests, and some had brain scans to look for white matter hyperintensities—areas where small vessel disease may have damaged brain tissue—and for amyloid plaques, a protein that can build up and is linked to Alzheimer’s disease.
During the study, 14% of the people with chronic insomnia developed mild cognitive impairment or dementia, compared to 10% of those who did not have insomnia.
After accounting for factors like age, high blood pressure, use of sleep medications and a diagnosis of sleep apnea, they found that people with insomnia were 40% more likely to develop mild cognitive impairment or dementia than those without insomnia. They also had faster declines on tests measuring different thinking skills.
Among those with insomnia, researchers determined the type: those getting less sleep than usual in the past two weeks; or those getting more sleep than usual in the past two weeks.
People who reported getting less sleep than usual were more likely to have lower cognitive test scores at the beginning of the study, comparable to being four years older. They also had more white matter hyperintensities and amyloid plaques. For amyloid, the effect was similar to what is seen in people with the APOE ε4 gene, a known genetic risk factor.
People who reported getting more sleep than usual, on the other hand, were more likely to have fewer white matter hyperintensities at the start of the study.
Some groups were especially vulnerable. Participants who carry the APOE ε4 gene—linked to higher Alzheimer’s risk—showed steeper declines in memory and thinking skills.
“Our results suggest that insomnia may affect the brain in different ways, involving not only amyloid plaques, but also small vessels supplying blood to the brain,” Carvalho said. “This reinforces the importance of treating chronic insomnia—not just to improve sleep quality but potentially to protect brain health as we age. Our results also add to a growing body of evidence that sleep isn’t just about rest—it’s also about brain resilience.”
A limitation of the study was that insomnia diagnoses came from medical records, which do not capture undiagnosed cases or reflect how severe symptoms are.
The study was supported by the National Institutes of Health, GHR Foundation, Mayo Foundation for Medical Education and Research, and a grant from Sleep Number Corporation to the Mayo Clinic.
Discover more about brain health at BrainandLife.org, the American Academy of Neurology. This resource also offers a magazine, podcast, and books that connect patients, caregivers and anyone interested in brain health with the most trusted information, straight from the world’s leading experts in brain health. Follow Brain & Life® on Facebook, X, and Instagram.
The American Academy of Neurology is the leading voice in brain health. As the world’s largest association of neurologists and neuroscience professionals with more than 40,000 members, the AAN provides access to the latest news, science and research affecting neurology for patients, caregivers, physicians and professionals alike. The AAN’s mission is to enhance member career fulfillment and promote brain health for all. A neurologist is a doctor who specializes in the diagnosis, care and treatment of brain, spinal cord and nervous system diseases such as Alzheimer's disease, stroke, concussion, epilepsy, Parkinson's disease, multiple sclerosis, headache and migraine.
Explore the latest in neurological disease and brain health, from the minds at the AAN at AAN.com or find us on Facebook, X, Instagram, LinkedIn, and YouTube.
END
Can’t sleep? Insomnia associated with accelerated brain aging
2025-09-10
(Press-News.org)
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