Discontinuation of semaglutide among older adults with diabetes in the US and Japan

JAMA Cardiology

2025-09-24

(Press-News.org) About The Study: In this binational study of older adults with diabetes, nearly 6 in 10 U.S. adults and 3 in 10 Japanese adults discontinued glucagon-like peptide-1 receptor agonists (GLP-1RAs) within 12 months of initiating injectable semaglutide. Patients with established cardiovascular disease and chronic kidney disease had higher discontinuation rates in both countries, which is troublesome given the substantial clinical benefit these high-risk individuals would be expected to derive from GLP-1RA therapy.

Corresponding Author: To contact the corresponding author, Dhruv S. Kazi, MD, MSc, MS, email dkazi@bidmc.harvard.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamacardio.2025.3109)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.

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