Trial enrollment and survival disparities among patients with advanced epithelial ovarian carcinoma

JAMA Network Open

2025-10-22

(Press-News.org) About The Study: In this cohort study of more than 1,900 patients in randomized clinical trials (RCTs) for advanced epithelial ovarian cancer, Black and Asian patients were underrepresented compared with the general population estimates in the U.S., and Black patients had worse survival outcomes compared with white and Asian patients, despite having similar progression-free survival. Equitable enrollment in clinical trials ensures access to cutting-edge treatments and can lead to outcomes comparable to those of white counterparts. Sustained efforts to improve RCT diversity remain essential to long-term equity in cancer care and survival.

Corresponding Author: To contact the corresponding author, Alex A. Francoeur, MD, email francoea@hs.uci.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.38648)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Trial enrollment and survival disparities among patients with advanced epithelial ovarian carcinoma

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