(Press-News.org) E2F5 is a member of the E2F transcription factor family, and plays a key role in cell growth and proliferation. Overexpression of E2F5 has been reported in various human cancers, but not in liver cancer, and its biological implication is largely unknown. It is not known whether E2F5 plays a tumor suppressor role or an oncogenic role. Furthermore, there has been no report on the expression profile of E2F5 in HCC and its biological implications on hepatocarcinogenesis.
A research article published on January 28, 2011 in the World Journal of Gastroenterology addresses this question. In this study, the authors investigated the expression profile of E2F5 in primary HCCs and explored the biological effects of E2F5 overexpression by knockdown of the gene.
This is the first evidence that E2F5 is commonly overexpressed in primary human HCC and that E2F5 knockdown profoundly repressed the growth of HCC cells. The overexpression of E2F5 may induce uncontrollable cell cycle progression in liver cells and eventually contribute to cancer transformation by working together with other carcinogenic factors. This study will help to understand hepatocarcinogenesis mechanisms and to define therapeutic targets of early HCC.
INFORMATION:Reference: Jiang Y, Yim SH, Xu HD, Jung SH, Yang SY, Hu HJ, Jung CK, Chung YJ. A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. World J Gastroenterol 2011; 17(4): 470-477
http://www.wjgnet.com/1007-9327/full/v17/i4/470.htm
Correspondence to: Dr. Yeun-Jun Chung, Integrated Research Center for Genome Polymorphism and Department of Microbiology, School of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea. yejun@catholic.ac.kr
Telephone: +82-2-22587343 Fax: +82-2-5370572
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H. pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2009 IF: 2.092. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
END
Iron overload is a common and serious problem in thalassemic major patients. As iron accumulation is toxic in the body's tissues, accurate estimation of iron stores is of great importance in these patients to prevent iron overload by an appropriate iron chelating therapy. Liver biopsy is the gold standard for evaluating iron stores but it is an invasive method which is not easily repeatable in patients. Introduction of other more applicable methods seems to be necessary.
A research article published on January 28, 2011 in the World Journal of Gastroenterology addresses ...
Failure to tackle rising greenhouse gas emissions effectively has led to intensifying debate on geoengineering - deliberate large-scale schemes to slow the rate at which Earth is heating up. The public debate often mixes opinion with fact so scientists have now released the first summary for policymakers on ocean fertilization, one of the earliest geoengineering proposals. The authors report that the chances of success of using ocean fertilization to deal with climate change is low.
Ocean fertilization involves adding iron or other nutrients to the surface of the ocean ...
Nearly ten percent of all cases of depression are so severe that the patients do not respond to any established treatment method. Targeted stimulation of areas in the brain using a type of "brain pacemaker" has recently raised hopes: According to initial studies, half of patients with the most severe depression treated in this manner see a significant improvement in mood. Physicians from the University of Bonn, together with colleagues from the US, have suggested a new target structure for deep brain stimulation (as it is technically called). They hope to achieve an even ...
Computer engineers at North Carolina State University have developed hardware that allows programs to operate more efficiently by significantly boosting the speed at which the "cores" on a computer chip communicate with each other.
The core, or central processing unit, is the brain of a computer chip; most chips currently contain between four and eight cores. In order to perform a task more quickly using multiple cores on a single chip, those cores need to communicate with each other. But there are no direct ways for cores to communicate. Instead, one core sends data ...
In order to arrive at this result the researchers calculated the price with a model that measures the number of medals according to government expenditure in sport, along with other variables. "This model allows accurate measurement of how much extra expense is necessary to win each medal," the UC3M professors Juan de Dios Tena and Ramón J. Flores explained, who carried out this study within the Sports Economics Research Group, headed by professor David Forrest, of the University of Salford (England) and which also includes Ismael Sanz from the Universidad Rey Juan Carlos ...
If you think histamines are your nemesis during allergy season, here's something that might change your perspective. New research published in the Journal of Leukocyte Biology (http://www.jleukbio.org) shows that histamine could be an important molecule to developing new treatments for multiple sclerosis (MS). In the study, the scientists analyzed the role of histamine in an animal model of multiple sclerosis and found that histamine plays a critical role in preventing MS or lessening its effects.
"We hope that our study will help design new therapies for autoimmune ...
Milan, Italy, 31 January 2010 – Wouldn't life be easy if everything happened as we anticipated? In reality, our brains are able to adapt to the unexpected using an inbuilt network that makes predictions about the world and monitors how those predictions turn out. An area at the front of the brain, called the orbitofrontal cortex, plays a central role and studies have shown that patients with damage to this area confuse memories with reality and continue to anticipate events that are no longer likely to happen. The brain's ability to react adaptively, becomes crucial for ...
From the highest mountaintop comes a new research report in the FASEB Journal (http://www.fasebj.org) that gets to the bottom of what happens to the hearts of people when exposed to low-levels of oxygen, such as those on Mount Everest or in the intensive care unit of a hospital. In the study, researchers monitored subjects who spent time at the Mount Everest Base Camp and found that the low-level oxygen conditions at the base came caused changes in heart function resembling what is seen in conditions that severely restrict the amount of oxygen to the heart, such as cystic ...
Bats tend to have a bad reputation. They sleep all day, party at night, and are commonly thought to be riddled with rabies. A study by University of Calgary researchers has confirmed that bats are not as disease-ridden as the stigma suggests.
"The notion that bats have high rates of rabies is not true," says Brandon Klug, a graduate student at the University of Calgary and the lead author of a paper published in the Journal of Wildlife Diseases.
"Those of us that work with bats have always known the rates are low; and now we have evidence that bats aren't disease-ridden ...
Tel Aviv — The new environmentally-friendly concept of municipal "bike-sharing" is taking over European cities like Paris, and American cities like New York are also looking into the idea. It allows a subscriber to "borrow" a bike from one of hundreds of locations in the city, use it, and return it to another location at the end of the journey. It's good for commuters and for running short errands.
While the idea is gaining speed and subscribers at the 400 locations around the world where it has been implemented, there have been growing pains — partly because the projects ...