AAN issues new guideline for the management of functional seizures

EMBARGOED FOR RELEASE UNTIL 4:00 P.M. ET, WEDNESDAY, DECEMBER 10, 2025

Highlights:

A new guideline by the American Academy of Neurology says psychological interventions are possibly effective in helping people achieve freedom from functional seizures. Functional seizures, previously known as psychogenic nonepileptic seizures or non-epileptic attack disorder, can look or feel like seizures from epilepsy or fainting, but they have their own typical features. The guideline says appropriate treatment may decrease the frequency of functional seizures, decrease anxiety and improve quality of life. The guideline recommends that antiseizure medications such as benzodiazepines should not be prescribed for functional seizures without co-occurring epilepsy or another reason for these medications. As noted by the authors, functional seizures have been a misunderstood condition, and this guideline is a landmark effort to help overcome stigma. It is the first guideline from the AAN to focus on a functional neurological disorder. MINNEAPOLIS — To help neurologists, mental health clinicians and other clinicians determine the best ways to help people manage functional seizures, the American Academy of Neurology has issued a new guideline, published on December 10, 2025, in Neurology®, the medical journal of the American Academy of Neurology. The guideline is endorsed by the American Epilepsy Society.

Functional seizures, previously known as psychogenic nonepileptic seizures or non-epileptic attack disorder, are episodes that can look or feel like epilepsy or fainting, but with different causes and their own typical features.

“There is a growing body of evidence demonstrating that potentially effective treatments are available for functional seizures once an accurate diagnosis is made,” said guideline author Benjamin Tolchin, MD, MS, of the Yale School of Medicine in New Haven, Connecticut, and a Fellow of the American Academy of Neurology. “Nevertheless, most people with functional seizures do not receive targeted and evidence-based treatment, contributing to ongoing functional seizures and disability. Functional seizures have been a misunderstood condition, and this AAN guideline is a landmark effort to help overcome that stigma.”

The guideline is based on a careful review of the available evidence on the topic. The review found that psychological interventions are possibly effective in increasing the likelihood of achieving freedom from functional seizures, decreasing the frequency of functional seizures, decreasing anxiety and improving quality of life for people with functional seizures. Potentially effective psychological interventions include functional seizure–specific cognitive behavioral therapies, neuro-behavioral therapy, paradoxical therapy, and motivational interviewing in combination with psychotherapy.

To help determine whether a person is having functional seizures, seizures due to epilepsy, or a combination of both, the guideline recommends that clinicians ask people about the details of their seizures. This includes interviewing people who have witnessed the seizures, requesting any smartphone videos of the seizures and possibly conducting tests such as a video electroencephalogram (EEG).

It states that people diagnosed with functional seizures should also be evaluated for co-occurring epilepsy and psychiatric disorders.

The guideline recommends that a diagnosis is provided in a manner that is clear, empathetic and supportive. It also recommends that if appropriate, family and other care partners of the person with functional seizures be included in decisions about treatment.

The guideline says when psychological interventions such as cognitive behavioral therapy are indicated, clinicians should counsel people about the benefits and risks. It states that psychological interventions are generally safe and well tolerated.

The guideline recommends that antiseizure medications such as benzodiazepines should not be prescribed for functional seizures without co-occurring epilepsy or another reason for these medications. It says people should be counseled about the potential risks and lack of evidence of benefit for using these medications for functional seizures alone. People with functional seizures should be tapered off these medications if there is not another reason for their use, according to the guideline.

“Many people with functional seizures are initially misdiagnosed with epilepsy and treated with antiseizure medications before the correct diagnosis is made,” said guideline author David L. Perez, MD, MMSc, of Harvard Medical School in Boston, Massachusetts, and a Fellow of the American Academy of Neurology. “Neurologists and other clinicians can use this guideline to help diagnose and manage functional seizures, improving a person’s quality of life and brain health overall.”

The guideline states that several areas related to functional seizures have limited or no evidence. It also says improved diagnostic techniques are needed and there may be potential for future use of machine learning, artificial intelligence or wearable devices to help with diagnosis.

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The American Academy of Neurology is the leading voice in brain health. As the world’s largest association of neurologists and neuroscience professionals with more than 40,000 members, the AAN provides access to the latest news, science and research affecting neurology for patients, caregivers, physicians and professionals alike. The AAN’s mission is to enhance member career fulfillment and promote brain health for all. A neurologist is a doctor who specializes in the diagnosis, care and treatment of brain, spinal cord and nervous system diseases such as Alzheimer's disease, stroke, concussion, epilepsy, Parkinson's disease, multiple sclerosis, headache and migraine.

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