Germline pathogenic variants among women without a history of breast cancer

JAMA Internal Medicine

2025-12-12

(Press-News.org) About The Study: In this secondary analysis of the WISDOM trial, a randomized clinical trial that enrolled women without breast cancer ages 40 to 74, criteria-independent genetic testing in a pragmatic trial identified a substantial number of women with clinically actionable results, many of whom would not have qualified for genetic
testing under current guidelines. These findings support broader access to genetic testing as part of personalized breast cancer risk assessment.

Corresponding Author: To contact the corresponding author, Lisa Madlensky, PhD, email lmadlensky@health.ucsd.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2025.7323)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being presented at the San Antonio Breast Cancer Symposium.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.7323?guestAccessKey=29a68f19-f585-48fe-90ae-b2c0d131ce8e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121225

END

ELSE PRESS RELEASES FROM THIS DATE:

Tanning beds triple melanoma risk, potentially causing broad DNA damage

2025-12-12

Study analyzed thousands of medical records to compare melanoma rates in tanning bed users vs. non-users, and sequenced 182 skin biopsies from tanning bed users and controls Tanning bed users carried double the mutation burden of controls In users, mutations appeared even in body areas that don’t get much sun exposure CHICAGO ---Tanning bed use is tied to almost a threefold increase in melanoma risk, and for the first time, scientists have shown how these devices cause melanoma-linked DNA damage across nearly the entire skin surface, reports a new study led by Northwestern Medicine and University of California, San ...

Unique bond identified as key to viral infection speed

2025-12-12

UNIVERSITY PARK, Pa. — Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new research led by scientists at Penn State reveals a deliberate imbalance in their shape that helps them infect their hosts. The finding, the researchers say, not only illuminates a fundamental viral strategy but also opens doors for antiviral drug design and molecular delivery technologies critical for vaccines, cancer therapies, medication development and ...

Indoor tanning makes youthful skin much older on a genetic level

2025-12-12

Tanning bed users are known to have a higher risk of skin cancer, but for the first time researchers have found that young indoor tanners undergo genetic changes that can lead to more mutations in their skin cells than people twice their age. The study, which was led by UC San Francisco and Northwestern University, appears Dec. 12 in Science Advances. “We found that tanning bed users in their 30s and 40s had even more mutations than people in the general population who were in their 70s and ...

Mouse model sheds new light on the causes and potential solutions to human GI problems linked to muscular dystrophy

2025-12-12

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also affects other organs, including the brain, heart and gastrointestinal (GI) tract. Although around 80% of people with DM1 experience GI problems that greatly reduce their quality of life, including difficulty swallowing, delayed stomach emptying, constipation and severe conditions like intestinal obstruction, the underlying causes remain understudied. To shed light onto the causes and potential solutions to ...

The Journal of Nuclear Medicine ahead-of-print tip sheet: December 12, 2025

2025-12-12

Reston, VA (December 12, 2025)—New research has been published ahead-of-print by The Journal of Nuclear Medicine (JNM). JNM is published by the Society of Nuclear Medicine and Molecular Imaging, an international scientific and medical organization dedicated to advancing nuclear medicine, molecular imaging, and theranostics—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes. Summaries of the newly published research articles are provided below. Tracking Kidney Cancer Spread with a New Targeted Imaging Tool This study explored whether two biomarkers—CD70 ...

Smarter tools for peering into the microscopic world

2025-12-12

The microscopic organisms that fill our bodies, soils, oceans and atmosphere play essential roles in human health and the planet’s ecosystems. Yet even with modern DNA sequencing, figuring out what these microbes are and how they are related to one another remains extremely difficult. In a pair of new studies, researchers at Arizona State University introduce powerful tools that make this work easier, more accurate and far more scalable. One tool improves how scientists build microbial family trees. The other provides a software foundation used worldwide to analyze ...

Applications open for funding to conduct research in the Kinsey Institute archives

2025-12-12

The Kinsey Institute invites applications for two competitive research awards that provide in-person access to the Institute’s internationally renowned Library & Special Collections at Indiana University Bloomington. These awards support original scholarship drawing on one of the world’s most significant archives on sexuality, relationships, gender, and human behavior—spanning manuscripts, publications, fine art, photography, ephemera, and scientific data across disciplines including biology, medicine, psychology, anthropology, ...

Global measure underestimates the severity of food insecurity

2025-12-12

(Santa Barbara, Calif.) — Before you can address a problem, you need to understand its scope. That’s why the United Nations developed the Integrated Food Security Phase Classification System. Aid organizations rely on analyses from this global partnership, which monitors and classifies the severity of food insecurity to help target assistance where and when it is most needed. These analyses are multifaceted and complex — often taking place in regions where data is scarce and conditions are deteriorating — and stakeholders tend to assume ...

Child survivors of critical illness are missing out on timely follow up care

2025-12-12

When the unthinkable happens and a child is left critically ill or injured, the miracle workers in pediatric intensive care units around the country work tirelessly to save their lives. Yet, after discharge from the hospital, many of these children could be missing out on vital follow up care, finds a study from Michigan Medicine. “There aren't specific guidelines in terms of whether or when a child should follow up with their primary care physician or pediatrician after a stay in the PICU,” ...

Risk-based vs annual breast cancer screening / the WISDOM randomized clinical trial

2025-12-12

About The Study: In a randomized clinical trial, researchers found risk-based breast cancer screening was as safe as annual screening for detecting advanced cancers but did not reduce breast biopsy rates. Corresponding author Laura J. Esserman, MD, MBA, of the University of California, San Francisco, will present the study at the San Antonio Breast Cancer Symposium. Corresponding Author: To interview Dr. Esserman, contact UCSF Senior Public Information Representative Elizabeth Fernandez by ...

Germline pathogenic variants among women without a history of breast cancer

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: