Nirsevimab vs RSVpreF vaccine for RSV–related hospitalization in newborns
JAMA
2025-12-22
(Press-News.org) About The Study: Compared with maternal vaccination with the respiratory syncytial virus (RSV) prefusion F protein (RSVpreF) vaccine, passive infant immunization with nirsevimab was associated with lower risks of RSV-related hospitalization and severe outcomes. These findings reflect the first RSV season with use of these immunization strategies in mainland France; their use should be reevaluated in future studies.
Corresponding Author: To contact the corresponding author, Marie-Joelle Jabagi, PharmD, PhD, email marie-joelle.jabagi@ansm.sante.fr.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2025.24082)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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2025-12-22
About The Study: According to the results of this population-based surveillance study, during 2024-2025, both maternal respiratory syncytial virus (RSV) vaccine and nirsevimab were estimated to be effective at protecting infants from RSV-associated hospitalizations in their first RSV season, and RSV-associated hospitalization rates in newborns and infants ages 0 to 11 months were reduced by up to half compared to seasons before these products were introduced.
Corresponding Author: To contact the corresponding author, Heidi L. Moline, MD, MPH, email ick6@cdc.gov.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamapediatrics.2025.5778)
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To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
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About The Study: In this meta-analysis, nirsevimab was associated with reduced lower respiratory tract infection-related hospitalizations and emergency department visits in infants and young children. These findings support nirsevimab’s potential to reduce respiratory-related morbidity in young children and health care utilization.
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To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamapediatrics.2025.5280)
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[Press-News.org] Nirsevimab vs RSVpreF vaccine for RSV–related hospitalization in newborns
JAMA
