(Press-News.org) LOS ANGELES — City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation’s top cancer centers by U.S. News & World Report, has opened a phase 2 clinical trial comparing three different strategies for protecting heart health in prostate cancer patients who receive androgen deprivation therapy (ADT), a potentially lifesaving hormone therapy.
“ADT is a cornerstone of prostate cancer treatment, but it can have significant unintended effects on cardiometabolic health,” said principal investigator Yun Rose Li, M.D., Ph.D., assistant professor and physician-scientist in the Department of Radiation Oncology at City of Hope. “Addressing these metabolic and cardiovascular consequences is essential to improving overall health, reducing long-term morbidity and optimizing outcomes for patients undergoing cancer therapy.”
The purpose of the study is to offset risk so people can continue to benefit from lifesaving ADT cancer treatment. Prostate cancer patients who receive ADT are at increased risk of cardiovascular disease, including heart attack, stroke and other heart and blood vessel problems. This may be due to treatment-related metabolic changes that can lead to weight gain, insulin resistance and an increase in body fat.
A focus of Dr. Li’s lab has been on mitigating the side effects of cancer treatments, including radiotherapy and ADT. The new trial builds on her previous work.
The trial will compare three approaches: intermittent fasting with a 16-hour fasting window, an anti-obesity medication targeting the body’s natural glucagon-like peptide-1 (GLP-1) signaling pathway and the American Heart Association’s Life’s Essential 8 guidelines. Participants will be assigned to follow one of these approaches for six months while continuing their cancer treatment of radiation and hormone therapy.
Researchers will conduct comprehensive assessments of participants’ metabolic and cardiovascular health, including clinical endpoints, biomarkers, imaging and other tools. Patients will be followed for 12 months after they complete the intervention portion of the study.
The trial’s primary goal is to determine if these interventions, which are already widely used in other clinical settings, are also feasible and safe for prostate cancer patients receiving hormone therapy.
“We hope to identify which strategy provides the greatest benefit for cardiometabolic health and which patients will benefit the most from prophylactic intervention,” said June-Wha Rhee, M.D., associate professor in City of Hope’s Division of Cardiology and a fellow study investigator. “These insights will inform future cancer care practices and help refine subsequent research aimed at mitigating treatment-related metabolic and cardiovascular risks.”
# # #
The clinical trial (NCT07202247) “Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial” aims to accrue 60 study participants.
About City of Hope
City of Hope's mission is to make hope a reality for all touched by cancer and diabetes. Founded in 1913, City of Hope has grown into one of the largest and most advanced cancer research and treatment organizations in the United States, and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center that is ranked among the nation’s top cancer centers by U.S. News & World Report at its core, City of Hope’s uniquely integrated model spans cancer care, research and development, academics and training, and a broad philanthropy program that powers its work. City of Hope’s growing national system includes its Los Angeles campus, Orange County, California, campus, a network of clinical care locations across Southern California and cancer treatment centers and outpatient facilities in the Atlanta, Chicago and Phoenix areas. City of Hope’s affiliated group of organizations includes Translational Genomics Research Institute and AccessHopeTM. For more information about City of Hope, follow us on Facebook, X, YouTube, Instagram and LinkedIn.
END
City of Hope opens clinical trial to protect heart health of prostate cancer patients receiving hormone therapy
Study compares intermittent fasting, GLP-1 medication and nutritional counseling to reduce cardiovascular and metabolic risks from androgen deprivation therapy
2026-01-26
ELSE PRESS RELEASES FROM THIS DATE:
High nursing school debt, proposed education loan caps threaten US health care access
2026-01-26
Audio
Nearly a third of registered nurses and advanced practice nurses in Michigan carry sizable student loan debt that is influencing their decision to leave the profession, according to a new study from the University of Michigan.
The research appears in Health Affairs Scholar, and comes as the U.S. Department of Education prepares to finalize new student loan rules that exclude graduate nursing programs from higher-tier loan limits, a move the study authors say could narrow the pathway for advanced clinicians and nursing faculty.
After the Trump administration proposed the loan limits, researchers from the U-M School ...
Chungnam National University team pioneers defect-free high-quality graphene electrodes
2026-01-26
Transparent electrodes transmit light while conducting electricity and are increasingly important in bioelectronic and optoelectronic devices. Their combination of high optical transparency, low electrical resistance, and mechanical flexibility makes them well suited for applications such as displays, solar cells, and wearable or implantable technologies.
In a significant advancement, researchers led by Professor Wonsuk Jung at Chungnam National University in the Republic of Korea have introduced a new fabrication technique called one-step free patterning of graphene, or OFP-G, which enables high-resolution patterning of large-area monolayer graphene with feature sizes ...
Antibodies targeting immunoglobulin E Cε2 region as potential rapid anti-allergy therapy
2026-01-26
Allergic diseases represent a major global health burden, placing significant strain on healthcare systems worldwide. Severe conditions such as anaphylaxis, asthma, food allergy, and allergic rhinitis are driven by immunoglobulin E (IgE), an antibody that binds to immune cells including mast cells and basophils. When IgE remains attached to these cells, it sustains exaggerated immune responses to allergens. Although current anti-allergy therapies can neutralize free IgE in the bloodstream, they cannot efficiently ...
Shrubs curb carbon emissions in China’s largest desert
2026-01-26
An experiment in western China over the past four decades shows that it is possible to tame the expansion of desert lands with greenery, and, in the process, pull excess carbon dioxide out of the sky.
The sprawling greening project along the edges of China’s Taklamakan Desert is creating a visible and measurable carbon sink, even in one of the driest places on Earth, according to a study led by scientists at the University of California, Riverside. The project is an example of successful afforestation, which is an effort to plant trees or shrubs on previously ...
Why U.S. middle-aged adults are falling behind peers abroad
2026-01-26
Americans born in the 1960s and early 1970s report higher loneliness and depressive symptoms and show poorer memory and physical strength than earlier generations. Such declines are largely absent in peer countries, particularly in Nordic Europe, where outcomes have improved over time.
In a new study, psychologist Frank J. Infurna of Arizona State University and co-authors, analyzed survey data from 17 countries seeking to identify why U.S. trends diverge from other wealthy nations.
“The real midlife crisis ...
Reducing sodium in everyday foods may yield heart-health benefits across populations
2026-01-26
Research Highlights:
A study in France found that if sodium reduction targets focused on reducing salt in baguettes and other breads, they could lower daily salt intake by 0.35 grams per person and reduce national deaths by more than 1,000.
A similar study in the United Kingdom found that if 2024 salt reduction goals in that country could lower daily salt intake by 17.5%, potentially preventing about 100,000 cases of ischemic heart disease and 25,000 ischemic strokes over 20 years through reduced blood pressure.
Both studies reinforce the importance of coordinated efforts among policymakers, the food industry and others to strengthen and enforce ...
Einstein Foundation Award 2026: Apply now for a €350,000 prize advancing research integrity and quality
2026-01-26
Researchers at all career stages, as well as institutions and initiatives, are invited to apply or nominate candidates for the prestigious international €350,000 Einstein Foundation Award – the only prize dedicated to honoring outstanding contributions to strengthening the rigor, reliability, robustness, and transparency of research across the humanities, social sciences, natural sciences, and life sciences.
The submission deadline is April 30, 2026, with winners to be announced at the end of the year.
The ...
First-of-its-kind probe monitors fetal health in utero during surgery
2026-01-26
Northwestern University researchers have developed the first device that can continuously track a fetus’s vital signs while still in the uterus — a feat that previously has not been possible.
The soft, flexible, robotic probe could dramatically improve safety during fetal surgeries, procedures in which physicians operate on a fetus before birth. Currently, doctors primarily rely on intermittent measurements of fetal heart rate using ultrasound imaging from outside the pregnant person’s body. The new device, on the other hand, can be gently inserted through the same ...
Major open access publisher appoints new office head in Korea
2026-01-26
Seoul, South Korea (January 26, 2026)—MDPI, the open access publisher, has appointed Sangwoo Lee as head of its South Korea office. Mr. Lee joins from Public Relations agency Prain Global, where he served for more than three years as chief director of strategic communications consulting institute. In his new role, Mr. Lee will lead MDPI’s operations in South Korea and oversee marketing, communications, and external affairs.
Mr. Lee brings more than 20 years of experience in communications (public affairs, crisis management, public policy, and public relations), including senior roles at Synergy Hill and Knowlton (now Synergy Burson) and Macoll Consulting Group. His ...
How does lifetime alcohol consumption affect colorectal cancer risk?
2026-01-26
Studies have demonstrated a link between alcohol consumption and an elevated risk of colorectal cancer. New research now reveals that higher lifetime alcohol consumption is also associated with a higher risk, especially for rectal cancer, and that quitting drinking can lower a person’s risk. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
When investigators analyzed data on US adults enrolled in the National Cancer Institute (NCI) Prostate, ...
LAST 30 PRESS RELEASES:
Father’s tobacco use may raise children’s diabetes risk
Structured exercise programs may help combat “chemo brain” according to new study in JNCCN
The ‘croak’ conundrum: Parasites complicate love signals in frogs
Global trends in the integration of traditional and modern medicine: challenges and opportunities
Medicinal plants with anti-entamoeba histolytica activity: phytochemistry, efficacy, and clinical potential
What a releaf: Tomatoes, carrots and lettuce store pharmaceutical byproducts in their leaves
Evaluating the effects of hypnotics for insomnia in obstructive sleep apnea
A new reagent makes living brains transparent for deeper, non-invasive imaging
Smaller insects more likely to escape fish mouths
Failed experiment by Cambridge scientists leads to surprise drug development breakthrough
Salad packs a healthy punch to meet a growing Vitamin B12 need
Capsule technology opens new window into individual cells
We are not alone: Our Sun escaped together with stellar “twins” from galaxy center
Scientists find new way of measuring activity of cell editors that fuel cancer
Teens using AI meal plans could be eating too few calories — equivalent to skipping a meal
Inconsistent labeling and high doses found in delta-8 THC products: JSAD study
Bringing diabetes treatment into focus
Iowa-led research team names, describes new crocodile that hunted iconic Lucy’s species
One-third of Americans making financial trade-offs to pay for healthcare
Researchers clarify how ketogenic diets treat epilepsy, guiding future therapy development
PsyMetRiC – a new tool to predict physical health risks in young people with psychosis
Island birds reveal surprising link between immunity and gut bacteria
Research presented at international urology conference in London shows how far prostate cancer screening has come
Further evidence of developmental risks linked to epilepsy drugs in pregnancy
Cosmetic procedures need tighter regulation to reduce harm, argue experts
How chaos theory could turn every NHS scan into its own fortress
Vaccine gaps rooted in structural forces, not just personal choices: SFU study
Safer blood clot treatment with apixaban than with rivaroxaban, according to large venous thrombosis trial
Turning herbal waste into a powerful tool for cleaning heavy metal pollution
Immune ‘peacekeepers’ teach the body which foods are safe to eat
[Press-News.org] City of Hope opens clinical trial to protect heart health of prostate cancer patients receiving hormone therapyStudy compares intermittent fasting, GLP-1 medication and nutritional counseling to reduce cardiovascular and metabolic risks from androgen deprivation therapy