GLP-1 RAs and prior major adverse limb events in patients with diabetes

JAMA Network Open

2026-01-28

(Press-News.org) About The Study: In this nationwide cohort study of patients with diabetes and prior major adverse limb events, treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) was associated with significantly lower risks of recurrent limb events, cardiovascular events, all-cause mortality, and kidney disease progression compared with dipeptidyl peptidase-4 inhibitors. These findings support the preferential use of GLP-1 RAs for secondary prevention in this high-risk population.

Corresponding Author: To contact the corresponding author, Pao-Hsien Chu, MD, email taipei.chu@gmail.com.

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(doi:10.1001/jamanetworkopen.2025.55952)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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GLP-1 RAs and prior major adverse limb events in patients with diabetes

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