Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis
2026-02-06
(Press-News.org) https://doi.org/10.1016/j.apsb.2025.09.037
This new article publication from Acta Pharmaceutica Sinica B, discusses an Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis.
Psoriasis is a prevalent chronic inflammatory skin disorder, characterized by epidermal thickening and an inflammatory hypoxic microenvironment, which significantly hinder drug penetration through the thickened skin and limit the efficacy of photodynamic therapy (PDT). The authors of this article introduce a dual-section microneedle (MN) patch (termed S-PTP MN patch) to enhance the therapeutic efficacy of psoriasis treatment. The needle section contains PTP nanoparticles (NPs) loaded with triamcinolone acetonide (TA) and coated with a reactive oxygen species (ROS)-responsive layer, while the base section of the patch encapsulates sodium percarbonate (SPC) particles that serve as oxygen generators to facilitate deep penetration of the PTP NPs into inflammatory sites and improve PDT efficacy. Moreover, the PTP NPs enable sustained release of TA drug over 6 days, demonstrating potent anti-inflammatory activity. In an imiquimod-induced psoriatic mouse model, a single application of the S-PTP MN patch demonstrated superior therapeutic efficacy compared to the conventional topical TA cream, with significantly alleviated clinical symptoms, reduced epidermal thickness, and lowered inflammatory cytokine levels, highlighting the potential of the S-PTP MN patch as a clinically translatable strategy for effective psoriasis therapy.
Keywords: Psoriasis, Microneedle, Responsive release, Drug delivery, Oxygen, Reactive oxygen species, Sustained release, Triamcinolone acetonide
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383525006458-ga1_lrg.jpg
A dual-section microneedle patch is designed to enhance the therapeutic efficacy of psoriasis treatment via sustained release of triamcinolone acetonide and generation of oxygen for deep penetration of drugs.
# # # # # #
The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/
Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board
APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).
Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).
CiteScore: 24.3
Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy)
JIF without self-citation: 13.8
ISSN 2211-3835
# # # # #
Yaqi Yuan, Peng Jiang, Chuan Xiao, Jiapeng Lei, Bo Cheng, Hankun Hu, Wei Li, Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis, Acta Pharmaceutica Sinica B, Volume 16, Issue 1, 2026, Pages 458-469, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2025.09.037
END
ELSE PRESS RELEASES FROM THIS DATE:
2026-02-06
Sepsis is a leading global cause of hospital deaths, occurring when the body’s response to infection damages tissue and causes organs to fail. Africa bears the world’s highest burden of sepsis, with an estimated 48 million cases each year leading to about 11 million deaths. People living with HIV face the greatest risk of dying from the condition.
A new study has found that tuberculosis, a chronic bacterial lung disease, is a major and long-overlooked cause of deadly sepsis among people living with HIV. An associated Phase 3 clinical trial called the ATLAS study found that starting tuberculosis (TB) treatment ...
2026-02-06
https://doi.org/10.1016/j.apsb.2025.10.027
This new article publication from Acta Pharmaceutica Sinica B, discusses how palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke.
Heat stroke (HS) is a severe medical emergency characterized by coagulation and high mortality due to organ injury. This study identifies a novel mechanism in which platelet ferroptosis, driven by transferrin receptor 1 (Tfr1) palmitoylation, significantly contributes to liver injury in HS. ...
2026-02-06
https://doi.org/10.1016/j.apsb.2025.10.028
This new article publication from Acta Pharmaceutica Sinica B, discusses how structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity.
Recent advances in ion channel structural biology have enhanced structure-based drug design, yet lipid-occupied binding pockets—often large and flat—remain a major hurdle for developing selective small molecules. TRPC5, a brain-enriched channel regulating depression and anxiety, is a promising therapeutic target, but current preclinical candidates suffer from moderate off-target effects. To address ...
2026-02-06
https://doi.org/10.1016/j.apsb.2025.11.025
This new article publication from Acta Pharmaceutica Sinica B, discusses therapeutic drug monitoring of biologics in inflammatory bowel disease.
Therapeutic drug monitoring (TDM) has emerged as a valuable tool for optimizing the use of biologics in inflammatory bowel disease (IBD). However, variations in focus, methodology, and recommendations among relevant guidelines and consensuses have contributed to inconsistencies in their quality. This guideline synthesizes current evidence to standardize TDM of biologics in IBD and improve patient ...
2026-02-06
A new global review highlights that tackling climate change requires more than funding or innovation alone. Researchers emphasize that meaningful climate action depends on the coordinated integration of financial systems, technological solutions, and governance reforms. The study presents a comprehensive framework designed to help countries, especially developing nations, implement effective and equitable climate strategies.
Climate change is increasingly threatening ecosystems, economies, and human well-being worldwide. ...
2026-02-06
Scientists have discovered that cyanobacteria, microscopic organisms best known for driving harmful algal blooms, may play a major role in spreading antibiotic resistance genes in coastal environments. The findings highlight a previously overlooked link between natural nutrient cycling and the global challenge of antibiotic resistance.
Antibiotic resistance genes enable bacteria to survive exposure to antibiotics, posing serious risks to public health, agriculture, and ecosystem stability. While these genes are widely detected in aquatic environments, their biological drivers and ecological roles have remained poorly understood.
In a new study examining ...
2026-02-06
Chestnut Hill, Mass. (2/6/2026) – Children across the globe engage in a constellation of behaviors that support cooperation, an action critical to the survival of the human species, a team of Boston College researchers report today in the journal Science Advances.
The team from Associate Professor of Psychology Katherine McAuliffe’s Cooperation Lab surveyed children in the urban United States, rural Uganda, Canada, and Peru, and the hunter-horticulturalist indigenous Shuar of Ecuador.
The researchers found there are cross-cultural regularities in some aspects of the development ...
2026-02-06
How do children learn to cooperate with others? A new cross-cultural study suggests that the answer depends less on universal rules and more on the social norms surrounding the child.
In the study, researchers examined how more than 400 children ages five to 13 from the United States, Canada, Peru, Uganda and the Shuar communities of Ecuador behaved in situations involving fairness, trust, forgiveness and honesty. The team also surveyed children and adults in each community to understand what people believed was the “right” thing to do.
The ...
2026-02-06
University of Phoenix announces the publication of “Bridging the AI skills gap: A blueprint for future‑proofing the workforce by including industry advisory councils for undergraduate environmental science program course redesign” in Industry and Higher Education. The article is authored by Jacquelyn Kelly, Ph.D., associate dean, College of General Studies; Dianna Gielstra, Ph.D., full-time faculty, Environmental Science Program, College of General Studies; Tomáš J. Oberding, Ph.D., full-time faculty, Environmental Science Program, College of General Studies, College of General Studies; Jim Bruno, MBA, associate dean, College of Business and ...
2026-02-06
Antibiotic resistance (AR) has steadily accelerated in recent years to become a global health crisis. As deadly bacteria evolve new ways to elude drug treatments for a variety of illnesses, a growing number of “superbugs” have emerged, ramping up estimates of more than 10 million worldwide deaths per year by 2050.
Scientists are looking to recently developed technologies to address the pressing threat of antibiotic-resistant bacteria, which are known to flourish in hospital settings, sewage treatment areas, animal husbandry locations ...
LAST 30 PRESS RELEASES:
[Press-News.org] Oxygen-boosted dual-section microneedle patch for enhanced drug penetration and improved photodynamic and anti-inflammatory therapy in psoriasis
