GLP-1 receptor agonists plus progestins and endometrial cancer risk in nonmalignant uterine diseases

JAMA Network Open

2026-02-10

(Press-News.org) About The Study: In this cohort study of women with benign uterine pathology or endometrial hyperplasia, combined glucagon-like peptide-1 receptor agonist (GLP-1RA) and progestin was associated with reduced endometrial cancer risk. Further investigation is warranted to assess its applicability and underlying mechanisms.

Corresponding Authors: To contact the corresponding authors, email Edward J. Tanner, MD, MBA, (etanner4@jh.edu) and James Cheng-Chung Wei, MD, PhD, (jccwei@gmail.com).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.58205)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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GLP-1 receptor agonists plus progestins and endometrial cancer risk in nonmalignant uterine diseases

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