Emergency department–initiated buprenorphine for opioid use disorder

JAMA

2026-02-11

(Press-News.org) About The Study: No difference was detected in opioid use disorder treatment engagement on day 7 between the 7-day extended-release and sublingual buprenorphine groups. Both buprenorphine formulations were well tolerated; precipitated withdrawal was rare despite a high prevalence of fentanyl.

Corresponding Author: To contact the corresponding author, Gail D’Onofrio, MD, email gail.dononfrio@yale.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.27019)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Emergency department–initiated buprenorphine for opioid use disorder

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