Telehealth improves access to genetic services for adult survivors of childhood cancers

Survivors at increased risk for subsequent cancer; testing for hereditary predisposition drives earlier detection, cuts mortality

2026-02-14

(Press-News.org) Adult survivors of childhood cancers are at higher risk for another cancer – such as breast, colorectal, sarcomas and thyroid cancer – that is not a relapse of their original illness. Previous cancer therapies are largely responsible, however up to 13 percent of survivors also have hereditary predisposition that elevates their risk of subsequent cancer. A recent clinical trial found that genetic services via remote centralized telehealth and in collaboration with primary care increased the uptake of genetic counseling and testing in this population. Results were published in Lancet Regional Health – Americas.

“Identifying survivors with cancer-predisposing genetic variants allows personalized survivorship care with early screenings and preventive measures,” said lead author Tara Henderson, MD, MPH, childhood cancer survivorship expert and Chair of Pediatrics at Ann & Robert H. Lurie Children’s Hospital of Chicago, as well as Professor of Pediatrics at Northwestern University Feinberg School of Medicine. “Our study is the first national randomized trial to show that remote telehealth services, working with primary care providers, improve access to genetic counseling and testing for adult survivors of childhood cancers. Genetic services also drive earlier detection of subsequent cancer, which reduces morbidity and mortality.”

The study included 391 participants, with the mean age of 44 years. All participants were provided with information on the benefits of genetic testing. Dr. Henderson and colleagues found that at six months, 43 percent of participants in the remote telehealth services group received genetic services, compared to 15 percent in the usual care group.

“Notably, 10 percent of participants who completed genetic testing in the telehealth group had actionable results, which underscores the significant impact of this intervention for the survivors and their families,” said Dr. Henderson. “Better access to genetic services is critical for improving outcomes in childhood cancer survivors. We show that integrating remote genetic services in primary care works well, although more survivors still need to pursue genetic testing. Enhancing motivation for testing may require personalized decision aids, further education about its benefits, and financial support mechanisms to reduce concerns about testing costs.”

Ann & Robert H. Lurie Children’s Hospital of Chicago is a nonprofit organization committed to providing access to exceptional care for every child. It is the only independent, research-driven children’s hospital in Illinois and one of less than 35 nationally. This is where the top doctors go to train, practice pediatric medicine, teach, advocate, research and stay up to date on the latest treatments. Exclusively focused on children, all Lurie Children’s resources are devoted to serving their needs. Research at Lurie Children’s is conducted through Stanley Manne Children’s Research Institute, which is focused on improving child health, transforming pediatric medicine and ensuring healthier futures through the relentless pursuit of knowledge. Lurie Children’s is the pediatric training ground for Northwestern University Feinberg School of Medicine. It is ranked as one of the nation’s top children’s hospitals by U.S. News & World Report.

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