Holding vs continuing GLP-1/GIP agonists before upper endoscopy

JAMA Internal Medicine

2026-03-16

(Press-News.org) About The Study: This randomized clinical trial found that continuing glucagon-like peptide-1 (GLP-1) or glucose-dependent insulinotropic polypeptide (GIP) agonist in the preprocedural period increased clinically significant residual gastric volume (RGV) but did not increase the risk of other adverse events. Clear liquids the day prior to the procedure may mitigate the risk of clinically significant RGV regardless of GLP-1/GIP use.

Corresponding Author: To contact the corresponding author, Tilak Shah, MD, MHS, email shaht3@ccf.org.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2026.0027)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Holding vs continuing GLP-1/GIP agonists before upper endoscopy

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