Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia

Innovation in science

2011-04-02

(Press-News.org) Study shows, for the first time, the successful reprogramming of diseased human hepatocytes into induced pluripotent stem cells (iPSC).1

Results also found differentiation into mature hepatocytes was more efficient than that with fibroblast-derived iPSCs.

The generation of diseased hepatocyte-derived human iPSC lines provides a good basis for the study of liver disease pathogenesis.

Such technology could give a potentially unlimited reservoir of cells for the treatment of human liver diseases: generating genetically corrected liver cells via auto-transplantation of genetically modified hepatocytes, thus avoiding liver transplant and lifelong immunosuppression.

### References 1 Bosman, A. et al. Progress toward the clinical application of autologus induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia. Abstract presented at The International Liver CongressTM 2011. http://www1.easl.eu/easl2011/program/Orals/187.htm

ELSE PRESS RELEASES FROM THIS DATE:

Dentist in West Orange, NJ Offers Patients Opportunity to Learn About Other Patients' Experiences

2011-04-02

Skilled West Orange dentist, Dr. Paul Feldman, allows patients to submit reviews of himself, his practice and his staff. The reviews are easily accessible via the practice's website and allow patients to view how other patients' experiences were. Patients can visit the website for this West Orange, NJ dentist to read reviews from previous patients who have received treatment from Dr. Feldman. "It is important that I know what my patients concerns are and what I am doing correctly. I value their opinion and the patient review section allows me to find out what they think, ...

In vivo RNAi screening identifies new regulators of liver regeneration

2011-04-02

This study establishes a unique system to perform in vivo RNAi screens for genetically dissecting the cellular signalling networks that regulate hepatocyte proliferation during chronic liver damage.1 Functional in vivo validation studies show that stable knockdown of the candidate gene by different shRNAs can significantly increase the repopulation efficiency of mouse hepatocytes and also increase the regenerative capacity of chronically damaged mouse livers. Such detailed understanding of the signalling pathways involved in hepatocyte proliferation control holds the ...

New studies provide beneficial insights expanding the pool of liver grafts and transplants

2011-04-02

Berlin, Germany, 01 April 2011: Findings from two new studies presented today at the International Liver CongressTM confirm that there are options for clinicians to expand the pool of liver grafts for use in patients with liver disease. A UK retrospective study analysed liver transplant donation after cardiac death (DCD) between May 2001 and October 2010.1 186 DCD allografts were used for transplantation and included 19 paediatric recipients. Overall the study found positive outcomes of transplant, with an overall patient survival of 89.9%, 85.6% and 83.6% at one, three ...

Smile Gallery for Warrenton Dentist Effectively Displays Smile Transformations

2011-04-02

Drs. Yung and Jelinek, experienced Warrenton dentists, are pleased to announce the addition of a smile gallery to their innovative website. Patients can now access pictures of previous patient's before and after treatment photos for a look at Drs. Yung and Jelinek's expertise and skillful cosmetic work. When accesses the online smile gallery, patients have the option to view before-and-after photos of procedures such as: anterior crowns, bleaching, crowns, crown replacement, implants and bridges, implants and crowns, orthodontics, and porcelain veneers. "We want our ...

First vaccine for viral hepatitis C could become a reality

2011-04-02

Berlin, Germany, Friday 01 April 2011: Early data from phase I trials of an HCV vaccine presented today at the International Liver CongressTM show encouraging results, with high immunogenicity and good safety profile.1,2 In the first study1, a therapeutic T-cell vaccine, based on novel adenoviral vectors was used on a small population of treatment naive patients with chronic genotype 1 HCV infection. Intra-muscular vaccination was administered 2 or 14 weeks into a 48-week course of treatment with Peg-IFNa2a/ribavirin. 50% of vaccinated patients had CD4+ and CD8+ HCV specific ...

The future looks bright for HCV patients who have failed to respond to current treatments

2011-04-02

Berlin, Germany, Friday 1st April 2011: Highly anticipated data from a number of clinical trials presented for the first time at the International Liver CongressTM confirmed that a range of new proteases inhibitors will help treat patients who have previously failed therapy for the treatment of chronic hepatitis C.1,2,3,4,5 The treatments have been tested for efficacy and safety in combination with PegIFN-alpha and ribavirin in patients that have previously failed treatment (either non-responder or relapse). Following different treatment and dosing, all of the trials ...

Fratricide of HBV-specific CD8 T cells by NK cells mediated through the TRAIL pathway

2011-04-02

A new study presented today at the International Liver CongressTM shows a novel pathway where activated natural killer (NK) cells expressing death ligands may excessively down-modulate the antiviral immune response in chronic HBV patients.1 Blocking the TNF-related apoptosis-inducing ligand (TRAIL) pathway partially reconstitutes HBV-specific T cells, suggesting that these cells are vulnerable to NK cell-mediated apoptosis through this death ligand pathway. NK cells are one of the main effectors of the innate immune response that plays a key role in containing intracellular ...

777 Dragon Casino Pays Out 100.16% On Poker Games

2011-04-02

777 Dragon Casino, who assert that they are the best Asian online casino, have definitely stepped up to the plate with their latest Casino Payout Reports. With the latest payout report that has been released by the independent auditing body who regularly audits the casino, during the month of February, 2011, Poker Games have proven to be a prominent part of the casino's payouts as they paid out 100.16%! Jessica Drake, spokesperson and manager at the casino, explained, "Receiving our payout report on a monthly basis keeps us in the know about how well our players are ...

Cinema Casino Cracks 100% in Payouts on Table Games

2011-04-02

Cinema Online Casino has just reported payouts of over 100% for Table Games during the month of February, 2011. Casino Table Games by definition include Blackjack, Poker, Craps, Baccarat and Roulette amongst other games. Victor Roberts, the representative for the casino, commented that Table Games seem to offer prominent payouts at the casino. "We have noticed a trend on Table Game Payouts over a period of time, and our Table Games definitely seem to be highly generous when it comes to our players and winners. We have had a run of great payouts for our players on Table ...

Win over $3,000,000 in Progressives at Casino Aus

2011-04-02

The prominent Australian Online Casino, Casino Aus has just announced that they have two major jackpots that are both ready to spill. The combined winnings from the two jackpots are sitting at over $3,000,000 "It is the first time in a long time that two of our most important progressives have matured simultaneously. Currently, they are growing fast and it is quite like a horse race to see which one will crack first. I think that this is going to be a photo finish. Currently, these jackpots are neck-in-neck, and standing on a combined value of over $3,000,000!" Conner ...

LAST 30 PRESS RELEASES:

New study finds air pollution increases inflammation primarily in patients with heart disease

AI finds undiagnosed liver disease in early stages

The American Society of Tropical Medicine and Hygiene and the Bill & Melinda Gates Foundation announce new research fellowship in malaria genomics in honor of professor Dominic Kwiatkowski