Prenatal exposure to certain pollutants linked to behavioral problems in young children

(Press-News.org) Mothers' exposure during pregnancy to pollutants created by the incomplete combustion of fossil fuels and other organic material may lead to behavioral problems in their children, according to a new study. Researchers found that within a sample of 215 children monitored from birth, those children with high levels of a pollution exposure marker in their cord blood had more symptoms of attention problems and anxiety/depression at ages 5 and 7 than did children with lower exposure. The study, "PAH/Aromatic DNA Adducts in Cord Blood and Behavior Scores in New York City Children," is published in Environmental Health Perspectives online April 12, 2011 and is to be released in an upcoming print issue. The researchers measured a biologic marker or "fingerprint" of exposure to polycyclic aromatic hydrocarbons (PAH) and other combustion-related pollutants in newborns' cord blood. When inhaled by the mother during pregnancy, these pollutants can be transferred across the placenta and bind to the DNA of the fetus, forming "adducts" in blood and other tissues and providing a biologic measure of pollutant exposure. Mothers completed a detailed assessment of their child's behavior.

In urban air, traffic emissions are a dominant source of the pollutants measured in the study. The authors accounted for other sources such as environmental tobacco smoke and diet in their analyses. None of the mothers in the study were smokers.

The study by researchers at the Columbia Center for Children's Environmental Health (CCCEH) and the Institute of Cancer Research in England is the first to examine the behavioral effects of prenatal exposure to these air pollutants in children using a biologic marker. "The results are of potential concern since attention problems and anxiety and depression may affect subsequent academic performance as well as peer relationships and other aspects of societal functioning," said Dr. Frederica Perera, the study's lead author and Center Director. "Fortunately, it is possible to reduce these air pollutants through currently available pollution controls, energy efficiency, and alternative energy sources." ### Funding for the study was provided by NIEHS, the EPA and private foundations. To learn more about the Center's research please visit: www.ccceh.org About the Mailman School of Public Health Founded in 1922 as one of the first three public health academies in the nation, Columbia University's Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Mailman School is the third largest recipient of NIH grants among schools of public health. Its 300 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,000 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Mailman School is also home to numerous world-renowned research centers including the International Center for AIDS Care and Treatment Programs (ICAP), the National Center for Disaster Preparedness and the Center for Infection and Immunity. For more information, please visit www.mailman.columbia.edu